Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes
The nemo-like kinase (Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate (Caenorhabditis elegans, Drosophila melanogaster) and mammalian genomes ( Mus musculus and Homo sapiens) each contain only a single functional Nlk gene. The mouse genome also harbours a tr...
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| Veröffentlicht in: | Gene 2001-10, Vol.278 (1), p.161-165 |
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| creator | Kortenjann, Monika Wehrle, Christian Nehls, Michael C. Boehm, Thomas |
| description | The nemo-like kinase (Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate
(Caenorhabditis
elegans,
Drosophila
melanogaster) and mammalian genomes (
Mus
musculus and
Homo
sapiens) each contain only a single functional
Nlk gene. The mouse genome also harbours a transcriptionally silent processed
Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as β-catenin, GSKβ and Nlk) have been maintained in single copies. |
| doi_str_mv | 10.1016/S0378-1119(01)00710-7 |
| format | Article |
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(Caenorhabditis
elegans,
Drosophila
melanogaster) and mammalian genomes (
Mus
musculus and
Homo
sapiens) each contain only a single functional
Nlk gene. The mouse genome also harbours a transcriptionally silent processed
Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as β-catenin, GSKβ and Nlk) have been maintained in single copies.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(01)00710-7</identifier><identifier>PMID: 11707333</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; b-catenin ; Blotting, Southern ; Caenorhabditis elegans ; Caenorhabditis elegans - genetics ; chromosome 2 ; DNA - genetics ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Genome ; Genomes ; Humans ; LEF protein ; Mice ; Mitogen-Activated Protein Kinases - genetics ; Molecular Sequence Data ; Nemo-like kinase ; Nlk gene ; Protein Isoforms - genetics ; Pseudogenes - genetics ; Sequence Alignment ; Sequence Homology, Amino Acid ; TCF protein ; Wnt protein</subject><ispartof>Gene, 2001-10, Vol.278 (1), p.161-165</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-5129f18ab6ee6115e8c5f53626f79403b91d834d5752e7d5e112c2510d15a3bd3</citedby><cites>FETCH-LOGICAL-c392t-5129f18ab6ee6115e8c5f53626f79403b91d834d5752e7d5e112c2510d15a3bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378111901007107$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11707333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kortenjann, Monika</creatorcontrib><creatorcontrib>Wehrle, Christian</creatorcontrib><creatorcontrib>Nehls, Michael C.</creatorcontrib><creatorcontrib>Boehm, Thomas</creatorcontrib><title>Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes</title><title>Gene</title><addtitle>Gene</addtitle><description>The nemo-like kinase (Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate
(Caenorhabditis
elegans,
Drosophila
melanogaster) and mammalian genomes (
Mus
musculus and
Homo
sapiens) each contain only a single functional
Nlk gene. The mouse genome also harbours a transcriptionally silent processed
Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as β-catenin, GSKβ and Nlk) have been maintained in single copies.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>b-catenin</subject><subject>Blotting, Southern</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>chromosome 2</subject><subject>DNA - genetics</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>Genome</subject><subject>Genomes</subject><subject>Humans</subject><subject>LEF protein</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinases - genetics</subject><subject>Molecular Sequence Data</subject><subject>Nemo-like kinase</subject><subject>Nlk gene</subject><subject>Protein Isoforms - genetics</subject><subject>Pseudogenes - genetics</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>TCF protein</subject><subject>Wnt protein</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKUn0UM1k2ya9CSy-AWiB_Uc0maq0SbRpCv47-26ix4dBgaGZ-aFh5B9oCdAoTp9oFyqEgDqIwrHlEqgpVwjE1CyLinlap1MfpEtsp3zKx1LCLZJtgAklZzzCbm7D_1XEQMWAX0se_eGxZsLJmPxjOP2JfrYx-c5Fi6M_YlpwCaZAQsTbOGN96Z3Jizg6DHvko3O9Bn3VnOHPF1ePM6uy9v7q5vZ-W3Z8poNpQBWd6BMUyFWAAJVKzrBK1Z1sp5S3tRgFZ9aIQVDaQUCsJYJoBaE4Y3lO-Rw-fc9xY855kF7l1vsexMwzrOWjEmoVPUvCAoYnyo-gmIJtinmnLDT78l5k740UL0wrn-M64VOTUH_GNdyvDtYBcwbj_bvaqV4BM6WAI4-Ph0mnVuHoUXrEraDttH9E_ENAIGO-Q</recordid><startdate>20011031</startdate><enddate>20011031</enddate><creator>Kortenjann, Monika</creator><creator>Wehrle, Christian</creator><creator>Nehls, Michael C.</creator><creator>Boehm, Thomas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20011031</creationdate><title>Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes</title><author>Kortenjann, Monika ; Wehrle, Christian ; Nehls, Michael C. ; Boehm, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-5129f18ab6ee6115e8c5f53626f79403b91d834d5752e7d5e112c2510d15a3bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>b-catenin</topic><topic>Blotting, Southern</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>chromosome 2</topic><topic>DNA - genetics</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - genetics</topic><topic>Genome</topic><topic>Genomes</topic><topic>Humans</topic><topic>LEF protein</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinases - genetics</topic><topic>Molecular Sequence Data</topic><topic>Nemo-like kinase</topic><topic>Nlk gene</topic><topic>Protein Isoforms - genetics</topic><topic>Pseudogenes - genetics</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>TCF protein</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kortenjann, Monika</creatorcontrib><creatorcontrib>Wehrle, Christian</creatorcontrib><creatorcontrib>Nehls, Michael C.</creatorcontrib><creatorcontrib>Boehm, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kortenjann, Monika</au><au>Wehrle, Christian</au><au>Nehls, Michael C.</au><au>Boehm, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2001-10-31</date><risdate>2001</risdate><volume>278</volume><issue>1</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>The nemo-like kinase (Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate
(Caenorhabditis
elegans,
Drosophila
melanogaster) and mammalian genomes (
Mus
musculus and
Homo
sapiens) each contain only a single functional
Nlk gene. The mouse genome also harbours a transcriptionally silent processed
Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as β-catenin, GSKβ and Nlk) have been maintained in single copies.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11707333</pmid><doi>10.1016/S0378-1119(01)00710-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Gene, 2001-10, Vol.278 (1), p.161-165 |
| issn | 0378-1119 1879-0038 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals b-catenin Blotting, Southern Caenorhabditis elegans Caenorhabditis elegans - genetics chromosome 2 DNA - genetics Drosophila melanogaster Drosophila melanogaster - genetics Genome Genomes Humans LEF protein Mice Mitogen-Activated Protein Kinases - genetics Molecular Sequence Data Nemo-like kinase Nlk gene Protein Isoforms - genetics Pseudogenes - genetics Sequence Alignment Sequence Homology, Amino Acid TCF protein Wnt protein |
| title | Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes |
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