Patient-controlled pethidine after major upper abdominal surgery : comparison of the epidural and intravenous routes
We compared epidural (n = 17) and intravenous (n = 20) patient-controlled analgesia (PCA) using pethidine (bolus 10 mg, lockout interval 10 min, 4-h maximum dose 3 mg.kg(-1)) after total gastrectomy. We found that mean (SD) pethidine consumption in the first 24 h was 33% less in the epidural group [...
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| Veröffentlicht in: | Anaesthesia 2001-11, Vol.56 (11), p.1106-1112 |
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| creator | CHEN, P. P CHEAM, E. W MA, M LAM, K. K NGAN KEE, W. D GIN, T |
| description | We compared epidural (n = 17) and intravenous (n = 20) patient-controlled analgesia (PCA) using pethidine (bolus 10 mg, lockout interval 10 min, 4-h maximum dose 3 mg.kg(-1)) after total gastrectomy. We found that mean (SD) pethidine consumption in the first 24 h was 33% less in the epidural group [255 (85) mg] than in the intravenous group [379 (129) mg, p = 0.002], although most of this difference occurred in the first 8 h. Plasma concentrations of pethidine were lower at 8 h (p < 0.01) in the epidural group, but were similar at 24 h. Pain scores, side-effects, patient satisfaction and patient outcome were similar between groups. Epidural and intravenous pethidine PCA provided similar efficacy after major abdominal surgery, although the epidural route can reduce the amount of pethidine used initially. |
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P ; CHEAM, E. W ; MA, M ; LAM, K. K ; NGAN KEE, W. D ; GIN, T</creator><creatorcontrib>CHEN, P. P ; CHEAM, E. W ; MA, M ; LAM, K. K ; NGAN KEE, W. D ; GIN, T</creatorcontrib><description>We compared epidural (n = 17) and intravenous (n = 20) patient-controlled analgesia (PCA) using pethidine (bolus 10 mg, lockout interval 10 min, 4-h maximum dose 3 mg.kg(-1)) after total gastrectomy. We found that mean (SD) pethidine consumption in the first 24 h was 33% less in the epidural group [255 (85) mg] than in the intravenous group [379 (129) mg, p = 0.002], although most of this difference occurred in the first 8 h. Plasma concentrations of pethidine were lower at 8 h (p < 0.01) in the epidural group, but were similar at 24 h. Pain scores, side-effects, patient satisfaction and patient outcome were similar between groups. Epidural and intravenous pethidine PCA provided similar efficacy after major abdominal surgery, although the epidural route can reduce the amount of pethidine used initially.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>PMID: 11703246</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adolescent ; Adult ; Aged ; Analgesia, Epidural ; Analgesia, Patient-Controlled - methods ; Analgesics ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - blood ; Analgesics, Opioid - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; Drug Administration Schedule ; Female ; Gastrectomy ; Humans ; Infusions, Intravenous ; Male ; Medical sciences ; Meperidine - administration & dosage ; Meperidine - blood ; Meperidine - therapeutic use ; Middle Aged ; Neuropharmacology ; Pain Measurement ; Pain, Postoperative - drug therapy ; Patient Satisfaction ; Pharmacology. 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D</creatorcontrib><creatorcontrib>GIN, T</creatorcontrib><title>Patient-controlled pethidine after major upper abdominal surgery : comparison of the epidural and intravenous routes</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>We compared epidural (n = 17) and intravenous (n = 20) patient-controlled analgesia (PCA) using pethidine (bolus 10 mg, lockout interval 10 min, 4-h maximum dose 3 mg.kg(-1)) after total gastrectomy. We found that mean (SD) pethidine consumption in the first 24 h was 33% less in the epidural group [255 (85) mg] than in the intravenous group [379 (129) mg, p = 0.002], although most of this difference occurred in the first 8 h. Plasma concentrations of pethidine were lower at 8 h (p < 0.01) in the epidural group, but were similar at 24 h. Pain scores, side-effects, patient satisfaction and patient outcome were similar between groups. Epidural and intravenous pethidine PCA provided similar efficacy after major abdominal surgery, although the epidural route can reduce the amount of pethidine used initially.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesia, Epidural</subject><subject>Analgesia, Patient-Controlled - methods</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - blood</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meperidine - administration & dosage</subject><subject>Meperidine - blood</subject><subject>Meperidine - therapeutic use</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Patient Satisfaction</subject><subject>Pharmacology. 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D ; GIN, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p169t-684902fd3973645afaa7e828dd300fec72468a10cc8612775b38958fd53370a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesia, Epidural</topic><topic>Analgesia, Patient-Controlled - methods</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - blood</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meperidine - administration & dosage</topic><topic>Meperidine - blood</topic><topic>Meperidine - therapeutic use</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Patient Satisfaction</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, P. P</creatorcontrib><creatorcontrib>CHEAM, E. W</creatorcontrib><creatorcontrib>MA, M</creatorcontrib><creatorcontrib>LAM, K. K</creatorcontrib><creatorcontrib>NGAN KEE, W. D</creatorcontrib><creatorcontrib>GIN, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, P. P</au><au>CHEAM, E. W</au><au>MA, M</au><au>LAM, K. K</au><au>NGAN KEE, W. D</au><au>GIN, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patient-controlled pethidine after major upper abdominal surgery : comparison of the epidural and intravenous routes</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>56</volume><issue>11</issue><spage>1106</spage><epage>1112</epage><pages>1106-1112</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>We compared epidural (n = 17) and intravenous (n = 20) patient-controlled analgesia (PCA) using pethidine (bolus 10 mg, lockout interval 10 min, 4-h maximum dose 3 mg.kg(-1)) after total gastrectomy. We found that mean (SD) pethidine consumption in the first 24 h was 33% less in the epidural group [255 (85) mg] than in the intravenous group [379 (129) mg, p = 0.002], although most of this difference occurred in the first 8 h. Plasma concentrations of pethidine were lower at 8 h (p < 0.01) in the epidural group, but were similar at 24 h. Pain scores, side-effects, patient satisfaction and patient outcome were similar between groups. Epidural and intravenous pethidine PCA provided similar efficacy after major abdominal surgery, although the epidural route can reduce the amount of pethidine used initially.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>11703246</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adolescent Adult Aged Analgesia, Epidural Analgesia, Patient-Controlled - methods Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - therapeutic use Biological and medical sciences Double-Blind Method Drug Administration Schedule Female Gastrectomy Humans Infusions, Intravenous Male Medical sciences Meperidine - administration & dosage Meperidine - blood Meperidine - therapeutic use Middle Aged Neuropharmacology Pain Measurement Pain, Postoperative - drug therapy Patient Satisfaction Pharmacology. Drug treatments |
| title | Patient-controlled pethidine after major upper abdominal surgery : comparison of the epidural and intravenous routes |
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