Dynamic force spectroscopy of molecular adhesion bonds

Dynamic force spectroscopy of molecular adhesion bonds

Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Physical review letters 2000-06, Vol.84 (26 Pt 1), p.6126-6129
Hauptverfasser: Heymann, B, Grubmüller, H
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 6129
container_issue 26 Pt 1
container_start_page 6126
container_title Physical review letters
container_volume 84
creator Heymann, B
Grubmüller, H
description Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. We develop a theory that allows one to reconstruct force profiles from force spectra obtained from measurements at varying loading rates, without requiring increased resolution. We show that spectra obtained from measurements with different spring constants contain complementary information.
doi_str_mv 10.1103/PhysRevLett.84.6126
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72270044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72270044</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-7db337cddc6241fb58467fdca1bf0e3156ed99fc85ad2795ac6360eaa74711283</originalsourceid><addsrcrecordid>eNpNkE1LxDAURYMozjj6CwTpyl3HlyZNmqX4DQOK6DqkyQtTaZvatEL_vR1mFrN6m3Mv9x1CrimsKQV297Gd4if-bXAY1gVfC5qJE7KkIFUqKeWnZAnAaKoA5IJcxPgDADNTnJMFBaVmBJZEPE6taSqb-NBbTGKHduhDtKGbkuCTJtRox9r0iXFbjFVokzK0Ll6SM2_qiFeHuyLfz09fD6_p5v3l7eF-k1qmxJBKVzImrXNWZJz6Mi-4kN5ZQ0sPyGgu0CnlbZEbl0mVGyuYADRG8vmFrGArcrvv7frwO2IcdFNFi3VtWgxj1DLLJADnM8j2oJ3Xxx697vqqMf2kKeidLn2kSxdc73TNqZtD_Vg26I4yez_sH7KsaVM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72270044</pqid></control><display><type>article</type><title>Dynamic force spectroscopy of molecular adhesion bonds</title><source>American Physical Society Journals</source><creator>Heymann, B ; Grubmüller, H</creator><creatorcontrib>Heymann, B ; Grubmüller, H</creatorcontrib><description>Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. We develop a theory that allows one to reconstruct force profiles from force spectra obtained from measurements at varying loading rates, without requiring increased resolution. We show that spectra obtained from measurements with different spring constants contain complementary information.</description><identifier>ISSN: 0031-9007</identifier><identifier>EISSN: 1079-7114</identifier><identifier>DOI: 10.1103/PhysRevLett.84.6126</identifier><identifier>PMID: 10991140</identifier><language>eng</language><publisher>United States</publisher><ispartof>Physical review letters, 2000-06, Vol.84 (26 Pt 1), p.6126-6129</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-7db337cddc6241fb58467fdca1bf0e3156ed99fc85ad2795ac6360eaa74711283</citedby><cites>FETCH-LOGICAL-c396t-7db337cddc6241fb58467fdca1bf0e3156ed99fc85ad2795ac6360eaa74711283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2876,2877,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10991140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heymann, B</creatorcontrib><creatorcontrib>Grubmüller, H</creatorcontrib><title>Dynamic force spectroscopy of molecular adhesion bonds</title><title>Physical review letters</title><addtitle>Phys Rev Lett</addtitle><description>Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. We develop a theory that allows one to reconstruct force profiles from force spectra obtained from measurements at varying loading rates, without requiring increased resolution. We show that spectra obtained from measurements with different spring constants contain complementary information.</description><issn>0031-9007</issn><issn>1079-7114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpNkE1LxDAURYMozjj6CwTpyl3HlyZNmqX4DQOK6DqkyQtTaZvatEL_vR1mFrN6m3Mv9x1CrimsKQV297Gd4if-bXAY1gVfC5qJE7KkIFUqKeWnZAnAaKoA5IJcxPgDADNTnJMFBaVmBJZEPE6taSqb-NBbTGKHduhDtKGbkuCTJtRox9r0iXFbjFVokzK0Ll6SM2_qiFeHuyLfz09fD6_p5v3l7eF-k1qmxJBKVzImrXNWZJz6Mi-4kN5ZQ0sPyGgu0CnlbZEbl0mVGyuYADRG8vmFrGArcrvv7frwO2IcdFNFi3VtWgxj1DLLJADnM8j2oJ3Xxx697vqqMf2kKeidLn2kSxdc73TNqZtD_Vg26I4yez_sH7KsaVM</recordid><startdate>20000626</startdate><enddate>20000626</enddate><creator>Heymann, B</creator><creator>Grubmüller, H</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000626</creationdate><title>Dynamic force spectroscopy of molecular adhesion bonds</title><author>Heymann, B ; Grubmüller, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-7db337cddc6241fb58467fdca1bf0e3156ed99fc85ad2795ac6360eaa74711283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heymann, B</creatorcontrib><creatorcontrib>Grubmüller, H</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physical review letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heymann, B</au><au>Grubmüller, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic force spectroscopy of molecular adhesion bonds</atitle><jtitle>Physical review letters</jtitle><addtitle>Phys Rev Lett</addtitle><date>2000-06-26</date><risdate>2000</risdate><volume>84</volume><issue>26 Pt 1</issue><spage>6126</spage><epage>6129</epage><pages>6126-6129</pages><issn>0031-9007</issn><eissn>1079-7114</eissn><abstract>Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. We develop a theory that allows one to reconstruct force profiles from force spectra obtained from measurements at varying loading rates, without requiring increased resolution. We show that spectra obtained from measurements with different spring constants contain complementary information.</abstract><cop>United States</cop><pmid>10991140</pmid><doi>10.1103/PhysRevLett.84.6126</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0031-9007
ispartof Physical review letters, 2000-06, Vol.84 (26 Pt 1), p.6126-6129
issn 0031-9007
1079-7114
language eng
recordid cdi_proquest_miscellaneous_72270044
source American Physical Society Journals
title Dynamic force spectroscopy of molecular adhesion bonds
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A23%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20force%20spectroscopy%20of%20molecular%20adhesion%20bonds&rft.jtitle=Physical%20review%20letters&rft.au=Heymann,%20B&rft.date=2000-06-26&rft.volume=84&rft.issue=26%20Pt%201&rft.spage=6126&rft.epage=6129&rft.pages=6126-6129&rft.issn=0031-9007&rft.eissn=1079-7114&rft_id=info:doi/10.1103/PhysRevLett.84.6126&rft_dat=%3Cproquest_cross%3E72270044%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72270044&rft_id=info:pmid/10991140&rfr_iscdi=true