Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes

This study was designed to investigate whether angiotensin II induces the interleukin (IL)-6 family of cytokines in cardiac fibroblasts and, if so, whether these cytokines can augment cardiac hypertrophy. Angiotensin II increased IL-6, leukemia inhibitory factor (LIF) and cardiotrophin-1 mRNA by 6.5...

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Veröffentlicht in:	The Journal of biological chemistry 2000-09, Vol.275 (38), p.29717-29723
Hauptverfasser:	Sano, Motoaki, Fukuda, Keiichi, Kodama, Hiroaki, Pan, Jing, Saito, Mikiyoshi, Matsuzaki, Junichi, Takahashi, Toshiyuki, Makino, Shinji, Kato, Takahiro, Ogawa, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Cardiomegaly - etiology Cardiomegaly - metabolism Cardiomegaly - pathology Cells, Cultured Cytokines - biosynthesis Fibroblasts - metabolism Fibroblasts - pathology Growth Inhibitors - biosynthesis Interleukin-6 - biosynthesis Leukemia Inhibitory Factor Lymphokines - biosynthesis Mice Mice, Inbred ICR Myocardium - metabolism Myocardium - pathology Rats Rats, Wistar Vasoconstrictor Agents - pharmacology
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