Extraocular light therapy in winter depression: a double-blind placebo-controlled study
Background: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light therapy. Extraocular light has been reported to produce phase-shifts...
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| Veröffentlicht in: | Biological psychiatry (1969) 2001-11, Vol.50 (9), p.691-698 |
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| container_title | Biological psychiatry (1969) |
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| creator | Koorengevel, Kathelijne M. Gordijn, Marijke C.M. Beersma, Domien G.M. Meesters, Ybe den Boer, Johan A. van den Hoofdakker, Rutger H. Daan, Serge |
| description | Background: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light therapy. Extraocular light has been reported to produce phase-shifts of the human circadian pacemaker. This allows a double-blind, placebo-controlled study of light therapy in SAD.
Methods: Twenty-nine SAD patients participated. Clinical state was measured on days 1, 8, and 15 of the protocol. From days 4 through 8, 15 patients (4 M, 11 F) received extraocular light by fiberoptic illumination, and 14 (4 M, 10 F) placebo (no light) in the popliteal fossae, from 8
am to 11
am. In the evenings of days 3 and 8, the salivary dim light melatonin onset (DLMO) was assessed. Patients completed daily self-ratings on mood, alertness, and sleep.
Results: Both conditions showed a progressive improvement of clinical state over time. Between conditions, no significant differences were observed in clinical scores, the self-ratings on mood and alertness, and in timing of the DLMO before and directly after treatment.
Conclusions: The response to extraocular light therapy in SAD patients did not exceed its placebo effect. Extraocular light did not induce a phase shift of the circadian pacemaker. |
| doi_str_mv | 10.1016/S0006-3223(01)01182-9 |
| format | Article |
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Methods: Twenty-nine SAD patients participated. Clinical state was measured on days 1, 8, and 15 of the protocol. From days 4 through 8, 15 patients (4 M, 11 F) received extraocular light by fiberoptic illumination, and 14 (4 M, 10 F) placebo (no light) in the popliteal fossae, from 8
am to 11
am. In the evenings of days 3 and 8, the salivary dim light melatonin onset (DLMO) was assessed. Patients completed daily self-ratings on mood, alertness, and sleep.
Results: Both conditions showed a progressive improvement of clinical state over time. Between conditions, no significant differences were observed in clinical scores, the self-ratings on mood and alertness, and in timing of the DLMO before and directly after treatment.
Conclusions: The response to extraocular light therapy in SAD patients did not exceed its placebo effect. Extraocular light did not induce a phase shift of the circadian pacemaker.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(01)01182-9</identifier><identifier>PMID: 11704076</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Body Temperature - physiology ; circadian pacemaker ; Circadian Rhythm - physiology ; Depression ; dim-light melatonin onset ; Double-Blind Method ; extraocular light ; Female ; Humans ; light therapy ; Male ; Medical sciences ; Melatonin - analysis ; Melatonin - metabolism ; Mood disorders ; phase-delay hypothesis ; Phototherapy - methods ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Saliva - chemistry ; Seasonal affective disorder ; Seasonal Affective Disorder - metabolism ; Seasonal Affective Disorder - therapy ; Surveys and Questionnaires</subject><ispartof>Biological psychiatry (1969), 2001-11, Vol.50 (9), p.691-698</ispartof><rights>2001 Society of Biological Psychiatry</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-b48c14f73611715eb1af867fe5302edc55a41afa53b1e7d54d4ab0f1e71c656e3</citedby><cites>FETCH-LOGICAL-c391t-b48c14f73611715eb1af867fe5302edc55a41afa53b1e7d54d4ab0f1e71c656e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322301011829$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14097288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11704076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koorengevel, Kathelijne M.</creatorcontrib><creatorcontrib>Gordijn, Marijke C.M.</creatorcontrib><creatorcontrib>Beersma, Domien G.M.</creatorcontrib><creatorcontrib>Meesters, Ybe</creatorcontrib><creatorcontrib>den Boer, Johan A.</creatorcontrib><creatorcontrib>van den Hoofdakker, Rutger H.</creatorcontrib><creatorcontrib>Daan, Serge</creatorcontrib><title>Extraocular light therapy in winter depression: a double-blind placebo-controlled study</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light therapy. Extraocular light has been reported to produce phase-shifts of the human circadian pacemaker. This allows a double-blind, placebo-controlled study of light therapy in SAD.
Methods: Twenty-nine SAD patients participated. Clinical state was measured on days 1, 8, and 15 of the protocol. From days 4 through 8, 15 patients (4 M, 11 F) received extraocular light by fiberoptic illumination, and 14 (4 M, 10 F) placebo (no light) in the popliteal fossae, from 8
am to 11
am. In the evenings of days 3 and 8, the salivary dim light melatonin onset (DLMO) was assessed. Patients completed daily self-ratings on mood, alertness, and sleep.
Results: Both conditions showed a progressive improvement of clinical state over time. Between conditions, no significant differences were observed in clinical scores, the self-ratings on mood and alertness, and in timing of the DLMO before and directly after treatment.
Conclusions: The response to extraocular light therapy in SAD patients did not exceed its placebo effect. Extraocular light did not induce a phase shift of the circadian pacemaker.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - physiology</subject><subject>circadian pacemaker</subject><subject>Circadian Rhythm - physiology</subject><subject>Depression</subject><subject>dim-light melatonin onset</subject><subject>Double-Blind Method</subject><subject>extraocular light</subject><subject>Female</subject><subject>Humans</subject><subject>light therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - analysis</subject><subject>Melatonin - metabolism</subject><subject>Mood disorders</subject><subject>phase-delay hypothesis</subject><subject>Phototherapy - methods</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Saliva - chemistry</subject><subject>Seasonal affective disorder</subject><subject>Seasonal Affective Disorder - metabolism</subject><subject>Seasonal Affective Disorder - therapy</subject><subject>Surveys and Questionnaires</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQQK0KVBbKTyjypag9hHqcOB9cEFrRgoTUQ0EcLceeFCNvnNpO6f57DLuCI6fxjN54Zh4hn4GdAIP6-2_GWF2UnJdfGXxjAC0vug9kAW1TFrxifIcsXpE9sh_jQ04bzuEj2QNoWMWaekHuLv6noLyenQrU2T_3iaZ7DGpaUzvSRzsmDNTgFDBG68dTqqjxc--w6J0dDZ2c0tj7QvsxBe8cGhrTbNafyO6gXMTDbTwgtz8ubpaXxfWvn1fL8-tClx2koq9aDdXQlHVeCQT2oIa2bgYUJeNotBCqyiUlyh6wMaIylerZkN-ga1FjeUCON_9Owf-dMSa5slGjc2pEP0eZD65b6EQGxQbUwccYcJBTsCsV1hKYfDYqX4zKZ12SgXwxKrvcd7QdMPcrNG9dW4UZ-LIFVNTKDUGN2sY3rmJdw9s2c2cbDrOOfxaDjNriqNHYgDpJ4-07qzwBuf2TQg</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Koorengevel, Kathelijne M.</creator><creator>Gordijn, Marijke C.M.</creator><creator>Beersma, Domien G.M.</creator><creator>Meesters, Ybe</creator><creator>den Boer, Johan A.</creator><creator>van den Hoofdakker, Rutger H.</creator><creator>Daan, Serge</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Extraocular light therapy in winter depression: a double-blind placebo-controlled study</title><author>Koorengevel, Kathelijne M. ; Gordijn, Marijke C.M. ; Beersma, Domien G.M. ; Meesters, Ybe ; den Boer, Johan A. ; van den Hoofdakker, Rutger H. ; Daan, Serge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-b48c14f73611715eb1af867fe5302edc55a41afa53b1e7d54d4ab0f1e71c656e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - physiology</topic><topic>circadian pacemaker</topic><topic>Circadian Rhythm - physiology</topic><topic>Depression</topic><topic>dim-light melatonin onset</topic><topic>Double-Blind Method</topic><topic>extraocular light</topic><topic>Female</topic><topic>Humans</topic><topic>light therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin - analysis</topic><topic>Melatonin - metabolism</topic><topic>Mood disorders</topic><topic>phase-delay hypothesis</topic><topic>Phototherapy - methods</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Saliva - chemistry</topic><topic>Seasonal affective disorder</topic><topic>Seasonal Affective Disorder - metabolism</topic><topic>Seasonal Affective Disorder - therapy</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koorengevel, Kathelijne M.</creatorcontrib><creatorcontrib>Gordijn, Marijke C.M.</creatorcontrib><creatorcontrib>Beersma, Domien G.M.</creatorcontrib><creatorcontrib>Meesters, Ybe</creatorcontrib><creatorcontrib>den Boer, Johan A.</creatorcontrib><creatorcontrib>van den Hoofdakker, Rutger H.</creatorcontrib><creatorcontrib>Daan, Serge</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koorengevel, Kathelijne M.</au><au>Gordijn, Marijke C.M.</au><au>Beersma, Domien G.M.</au><au>Meesters, Ybe</au><au>den Boer, Johan A.</au><au>van den Hoofdakker, Rutger H.</au><au>Daan, Serge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extraocular light therapy in winter depression: a double-blind placebo-controlled study</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>50</volume><issue>9</issue><spage>691</spage><epage>698</epage><pages>691-698</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light therapy. Extraocular light has been reported to produce phase-shifts of the human circadian pacemaker. This allows a double-blind, placebo-controlled study of light therapy in SAD.
Methods: Twenty-nine SAD patients participated. Clinical state was measured on days 1, 8, and 15 of the protocol. From days 4 through 8, 15 patients (4 M, 11 F) received extraocular light by fiberoptic illumination, and 14 (4 M, 10 F) placebo (no light) in the popliteal fossae, from 8
am to 11
am. In the evenings of days 3 and 8, the salivary dim light melatonin onset (DLMO) was assessed. Patients completed daily self-ratings on mood, alertness, and sleep.
Results: Both conditions showed a progressive improvement of clinical state over time. Between conditions, no significant differences were observed in clinical scores, the self-ratings on mood and alertness, and in timing of the DLMO before and directly after treatment.
Conclusions: The response to extraocular light therapy in SAD patients did not exceed its placebo effect. Extraocular light did not induce a phase shift of the circadian pacemaker.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11704076</pmid><doi>10.1016/S0006-3223(01)01182-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Body Temperature - physiology circadian pacemaker Circadian Rhythm - physiology Depression dim-light melatonin onset Double-Blind Method extraocular light Female Humans light therapy Male Medical sciences Melatonin - analysis Melatonin - metabolism Mood disorders phase-delay hypothesis Phototherapy - methods Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Saliva - chemistry Seasonal affective disorder Seasonal Affective Disorder - metabolism Seasonal Affective Disorder - therapy Surveys and Questionnaires |
| title | Extraocular light therapy in winter depression: a double-blind placebo-controlled study |
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