Lack of Association Between N-ras Gene Mutations and Clinical Prognosis in Brazilian Children with Acute Lymphoblastic Leukemia

Point mutations in codons 12, 13 and 61 of the N-ras proto-oncogene have been detected in several human malignancies. We studied 170 patients with acute lymphoblastic leukemia (ALL), treated from 1988 to 1994 according to a protocol derived from BFM-83 studies, in order to evaluate the incidence and...

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Veröffentlicht in:	Leukemia & lymphoma 2001, Vol.42 (3), p.473-479
Hauptverfasser:	Diogo Clementino, Nelma Cristina, Yamamoto, Mihoko, Viana, Marcos Borato, Figueiredo, Maria Stella, Kerbauy, Jose, Ohlala Saad, Sara Terezinha, Costa, Fernando Ferreira
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukaemia ALL Amino Acid Substitution Base Sequence Bone Marrow Cells - chemistry Brazil Child Child, Preschool Cloning, Molecular Codon - genetics DNA - genetics DNA - isolation & purification DNA Primers DNA Probes Exons Female Genes, ras Glycine Humans Male N-ras gene mutations oncogene Point Mutation Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Serine
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