Molecular mechanism of staurosporine-induced apoptosis in osteoblasts

Staurosporine, a microbial alkaloid, is a strong inhibitor of protein kinases. We induced apoptosis in murine osteoblast MC3T3E-1 cells by exposure to the staurosporine. Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacological research 2000-10, Vol.42 (4), p.373-381
Hauptverfasser:	Chae, Han-Jung, Kang, Jang-Sook, Byun, Jong-Ook, Han, Kyung-Soo, Kim, Dae-Up, Oh, Se-Man, Kim, Hyung-Min, Chae, Soo-Wan, Kim, Hyung-Ryong
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Apoptosis Caspase 3 Caspases - chemistry Endopeptidases - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Mice Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Osteoblasts - drug effects Osteoblasts - enzymology Osteoblasts - metabolism Osteoblasts - pathology Phosphotransferases - metabolism Staurosporine - pharmacology staurosporine, osteoblast, apoptosis, caspase, transcriptional factor Transcription Factor AP-1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!