The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor

Telomerase activity is critical for normal and transformed human cells to escape from crisis and is implicated in oncogenesis. Here we describe a novel Pin2/TRF1 binding protein, PinX1 that inhibits telomerase activity and affects tumorigenicity. PinX1 and its small TID domain bind the telomerase ca...

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Veröffentlicht in:	Cell 2001-11, Vol.107 (3), p.347-359
Hauptverfasser:	Zhou, Xiao Zhen, Lu, Kun Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals chromosome 8 DNA-Binding Proteins - metabolism Gene Expression HeLa Cells Humans Mice Mice, Nude Molecular Sequence Data Neoplasms, Experimental Pin2/TRF1-binding protein PinX1 protein Telomerase - antagonists & inhibitors Telomerase - metabolism Telomeric Repeat Binding Protein 1 Tumor Cells, Cultured Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology
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