Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice

The anti‐inflammatory cytokine interleukin (IL)‐10 suppresses induciblenitric oxide synthase (iNOS); therefore, NO production should increasein the absence of IL‐10. Production of NO (as nitrite) bybronchoalveolar lavage cells of IL‐10 knockout (−/−) micewas assessed after ovalbumin sensitization an...

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Veröffentlicht in:	Journal of leukocyte biology 2001-11, Vol.70 (5), p.730-736
Hauptverfasser:	Ameredes, Bill T., Zamora, Ruben, Gibson, Kevin F., Billiar, Timothy R., Dixon‐McCarthy, Barbara, Watkins, Simon, Calhoun, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols allergen Animals Biomarkers bronchoalveolar lavage Bronchoalveolar Lavage Fluid - cytology C57BL6 mice Cell Count Cells, Cultured Enzyme Inhibitors - pharmacology Eosinophilia - etiology Eosinophilia - immunology Immunization Interleukin-10 - deficiency Interleukin-10 - genetics Interleukin-10 - physiology Lung - enzymology Lung - immunology macrophage Macrophages, Alveolar - physiology Male Mice Mice, Inbred C57BL Mice, Knockout nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II nitrite Nitrites - analysis Ornithine - analogs & derivatives Ornithine - pharmacology ovalbumin Ovalbumin - administration & dosage Ovalbumin - immunology Respiratory System - immunology Respiratory System - metabolism RNA, Messenger - biosynthesis Specific Pathogen-Free Organisms
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