Enhancement of Hippocampal Neurogenesis by Lithium
: Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell l...
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| Veröffentlicht in: | Journal of neurochemistry 2000-10, Vol.75 (4), p.1729-1734 |
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| creator | Chen, Guang Rajkowska, Grazyna Du, Fu Seraji‐Bozorgzad, Navid Manji, Husseini K. |
| description | : Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell lymphoma protein‐2 (bcl‐2) in areas of rodent brain and in cultured cells. In view of bcl‐2's antiapoptotic and neurotrophic effects, the present study was undertaken to determine if lithium affects neurogenesis in the adult rodent hippocampus. Mice were chronically treated with lithium, and 5‐bromo‐2‐deoxyuridine (BrdU) labeling of dividing cells was conducted over 12 days. Immunohistochemical analysis was undertaken 1 day after the last injection, and three‐dimensional stereological cell counting revealed that lithium produced a significant 25% increase in the BrdU‐labeled cells in the dentate gyrus. Double‐labeling immunofluorescence studies were undertaken to co‐localize BrdU‐positive cells with neuron‐specific nuclear protein and showed that ∼65% of the cells were double‐labeled. These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders. |
| doi_str_mv | 10.1046/j.1471-4159.2000.0751729.x |
| format | Article |
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Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell lymphoma protein‐2 (bcl‐2) in areas of rodent brain and in cultured cells. In view of bcl‐2's antiapoptotic and neurotrophic effects, the present study was undertaken to determine if lithium affects neurogenesis in the adult rodent hippocampus. Mice were chronically treated with lithium, and 5‐bromo‐2‐deoxyuridine (BrdU) labeling of dividing cells was conducted over 12 days. Immunohistochemical analysis was undertaken 1 day after the last injection, and three‐dimensional stereological cell counting revealed that lithium produced a significant 25% increase in the BrdU‐labeled cells in the dentate gyrus. Double‐labeling immunofluorescence studies were undertaken to co‐localize BrdU‐positive cells with neuron‐specific nuclear protein and showed that ∼65% of the cells were double‐labeled. These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.2000.0751729.x</identifier><identifier>PMID: 10987856</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>5‐Bromo‐2‐deoxyuridine ; Animals ; Antigens, Differentiation - metabolism ; bcl‐2 ; Biological and medical sciences ; Bromodeoxyuridine ; Cell Division - drug effects ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Immunohistochemistry ; Lithium ; Lithium - pharmacology ; Male ; Manic‐depressive illness ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Nerve Regeneration - drug effects ; Neurogenesis ; Neurons - cytology ; Neurons - drug effects ; Neurons - metabolism ; Neuropharmacology ; Pharmacology. Drug treatments ; Phenotype ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology</subject><ispartof>Journal of neurochemistry, 2000-10, Vol.75 (4), p.1729-1734</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5519-50a22fdcf8c32b048dd64209ecceb7636811a8775c82c6a379fddd84119cef213</citedby><cites>FETCH-LOGICAL-c5519-50a22fdcf8c32b048dd64209ecceb7636811a8775c82c6a379fddd84119cef213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.2000.0751729.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.2000.0751729.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,1430,27907,27908,45557,45558,46392,46816</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=825314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10987856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Guang</creatorcontrib><creatorcontrib>Rajkowska, Grazyna</creatorcontrib><creatorcontrib>Du, Fu</creatorcontrib><creatorcontrib>Seraji‐Bozorgzad, Navid</creatorcontrib><creatorcontrib>Manji, Husseini K.</creatorcontrib><title>Enhancement of Hippocampal Neurogenesis by Lithium</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell lymphoma protein‐2 (bcl‐2) in areas of rodent brain and in cultured cells. In view of bcl‐2's antiapoptotic and neurotrophic effects, the present study was undertaken to determine if lithium affects neurogenesis in the adult rodent hippocampus. Mice were chronically treated with lithium, and 5‐bromo‐2‐deoxyuridine (BrdU) labeling of dividing cells was conducted over 12 days. Immunohistochemical analysis was undertaken 1 day after the last injection, and three‐dimensional stereological cell counting revealed that lithium produced a significant 25% increase in the BrdU‐labeled cells in the dentate gyrus. Double‐labeling immunofluorescence studies were undertaken to co‐localize BrdU‐positive cells with neuron‐specific nuclear protein and showed that ∼65% of the cells were double‐labeled. These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders.</description><subject>5‐Bromo‐2‐deoxyuridine</subject><subject>Animals</subject><subject>Antigens, Differentiation - metabolism</subject><subject>bcl‐2</subject><subject>Biological and medical sciences</subject><subject>Bromodeoxyuridine</subject><subject>Cell Division - drug effects</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Lithium</subject><subject>Lithium - pharmacology</subject><subject>Male</subject><subject>Manic‐depressive illness</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nerve Regeneration - drug effects</subject><subject>Neurogenesis</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1PwzAMhiMEgjH4C6gCiVuLnaRJyg0mYKAJLnCOsjSFTv2iWcX272m1CnGEk2X5eW3rIeQcIULg4moVIZcYcoyTiAJABDJGSZNos0cmP6N9MgGgNGTA6RE59n4FgIILPCRHCImSKhYTQu-qD1NZV7pqHdRZMM-bprambEwRPLuurd9d5Xzug-U2WOTrj7wrT8hBZgrvTsc6JW_3d6-zebh4eXic3SxCG8eYhDEYSrPUZsoyugSu0lRwComz1i2lYEIhGiVlbBW1wjCZZGmaKo6YWJdRZFNyudvbtPVn5_xal7m3rihM5erOa0mpAPYHEKVIJCjWg9c70La1963LdNPmpWm3GkEPavVKD_704E8PavWoVm_68Nl4pVuWLv0V3bnsgYsRMN6aImt7r7n_4RSNGfKeut1RX3nhtv94QD89z8aGfQP8apPa</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Chen, Guang</creator><creator>Rajkowska, Grazyna</creator><creator>Du, Fu</creator><creator>Seraji‐Bozorgzad, Navid</creator><creator>Manji, Husseini K.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>Enhancement of Hippocampal Neurogenesis by Lithium</title><author>Chen, Guang ; Rajkowska, Grazyna ; Du, Fu ; Seraji‐Bozorgzad, Navid ; Manji, Husseini K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5519-50a22fdcf8c32b048dd64209ecceb7636811a8775c82c6a379fddd84119cef213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>5‐Bromo‐2‐deoxyuridine</topic><topic>Animals</topic><topic>Antigens, Differentiation - metabolism</topic><topic>bcl‐2</topic><topic>Biological and medical sciences</topic><topic>Bromodeoxyuridine</topic><topic>Cell Division - drug effects</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Lithium</topic><topic>Lithium - pharmacology</topic><topic>Male</topic><topic>Manic‐depressive illness</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nerve Regeneration - drug effects</topic><topic>Neurogenesis</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Guang</creatorcontrib><creatorcontrib>Rajkowska, Grazyna</creatorcontrib><creatorcontrib>Du, Fu</creatorcontrib><creatorcontrib>Seraji‐Bozorgzad, Navid</creatorcontrib><creatorcontrib>Manji, Husseini K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Guang</au><au>Rajkowska, Grazyna</au><au>Du, Fu</au><au>Seraji‐Bozorgzad, Navid</au><au>Manji, Husseini K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of Hippocampal Neurogenesis by Lithium</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2000-10</date><risdate>2000</risdate><volume>75</volume><issue>4</issue><spage>1729</spage><epage>1734</epage><pages>1729-1734</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell lymphoma protein‐2 (bcl‐2) in areas of rodent brain and in cultured cells. In view of bcl‐2's antiapoptotic and neurotrophic effects, the present study was undertaken to determine if lithium affects neurogenesis in the adult rodent hippocampus. Mice were chronically treated with lithium, and 5‐bromo‐2‐deoxyuridine (BrdU) labeling of dividing cells was conducted over 12 days. Immunohistochemical analysis was undertaken 1 day after the last injection, and three‐dimensional stereological cell counting revealed that lithium produced a significant 25% increase in the BrdU‐labeled cells in the dentate gyrus. Double‐labeling immunofluorescence studies were undertaken to co‐localize BrdU‐positive cells with neuron‐specific nuclear protein and showed that ∼65% of the cells were double‐labeled. 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| subjects | 5‐Bromo‐2‐deoxyuridine Animals Antigens, Differentiation - metabolism bcl‐2 Biological and medical sciences Bromodeoxyuridine Cell Division - drug effects Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Immunohistochemistry Lithium Lithium - pharmacology Male Manic‐depressive illness Medical sciences Mice Mice, Inbred C57BL Nerve Regeneration - drug effects Neurogenesis Neurons - cytology Neurons - drug effects Neurons - metabolism Neuropharmacology Pharmacology. Drug treatments Phenotype Proto-Oncogene Proteins c-bcl-2 - metabolism Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Enhancement of Hippocampal Neurogenesis by Lithium |
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