Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure

OBJECTIVES The study evaluated the transcardiac extraction or spillover of aldosterone (ALDO) in normal subjects and in patients with congestive heart failure (CHF). BACKGROUND Aldosterone promotes collagen synthesis and structural remodeling of target organs such as the heart. Spironolactone, an AL...

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Veröffentlicht in:	Journal of the American College of Cardiology 2000-09, Vol.36 (3), p.838-844
Hauptverfasser:	Tsutamoto, Takayoshi, Wada, Atsuyuki, Maeda, Keiko, Mabuchi, Naoko, Hayashi, Masaru, Tsutsui, Takashi, Ohnishi, Masato, Sawaki, Masahide, Fujii, Masanori, Matsumoto, Takehiro, Horie, Hajime, Sugimoto, Yoshihisa, Kinoshita, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aldosterone - blood Aldosterone - metabolism Aorta Biological and medical sciences Cardiovascular system Coronary Vessels Female Heart Failure - drug therapy Heart Failure - metabolism Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Mineralocorticoid Receptor Antagonists - therapeutic use Miscellaneous Myocardium - metabolism Peptide Fragments - blood Peptide Fragments - metabolism Pharmacology. Drug treatments Procollagen - blood Procollagen - metabolism Reference Values Spironolactone - therapeutic use Stroke Volume Ventricular Function, Left
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