Synthetic Receptors for CG Base Pairs

Synthetic Receptors for CG Base Pairs

Hydrogen-bond-mediated complexation of a CG base pair by a hexylureido phthalimide and a hexylureido isoindolin-1-one was studied by 1H NMR spectroscopy in an organic solvent. Chemical shift data indicate that both receptors effectively bind the CG base pair from the major groove side.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2000-09, Vol.2 (19), p.2931-2934
Hauptverfasser: Mertz, Eric, Mattei, Sebastiano, Zimmerman, Steven C
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Cytosine - chemistry
Cytosine - metabolism
Guanine - chemistry
Guanine - metabolism
Hydrogen Bonding
Indoles - chemical synthesis
Indoles - metabolism
Kinetics
Nuclear Magnetic Resonance, Biomolecular
Phthalimides - chemical synthesis
Phthalimides - metabolism
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - metabolism
Solvents
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Beschreibung
Zusammenfassung:Hydrogen-bond-mediated complexation of a CG base pair by a hexylureido phthalimide and a hexylureido isoindolin-1-one was studied by 1H NMR spectroscopy in an organic solvent. Chemical shift data indicate that both receptors effectively bind the CG base pair from the major groove side.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006157d