Expression of ciliary neurotrophic factor receptor in myasthenia gravis
In myasthenia gravis, high anti-nicotinic receptor (AChR) antibody titers are not always associated with severity of the disease, suggesting the involvement of other pathological effectors. We showed that ciliary neurotrophic factor receptor (CNTFR) gene expression was higher in muscle biopsy tissue...
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| Veröffentlicht in: | Journal of neuroimmunology 2001-11, Vol.120 (1), p.180-189 |
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| container_title | Journal of neuroimmunology |
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| creator | Poëa, Sandrine Guyon, Thierry Levasseur, Philippe Berrih-Aknin, Sonia |
| description | In myasthenia gravis, high anti-nicotinic receptor (AChR) antibody titers are not always associated with severity of the disease, suggesting the involvement of other pathological effectors. We showed that ciliary neurotrophic factor receptor (CNTFR) gene expression was higher in muscle biopsy tissue from severely affected MG patients regardless of anti-nAChR antibody titer. This increase was also triggered in vitro by a seric factor from MG patients. CNTFR protein expression was decreased in muscles from seropositive MG patients only.
Altogether, our data indicate that the alteration of CNTFR expression in some MG patients could contribute to the severity of the disease in a subgroup of patients. |
| doi_str_mv | 10.1016/S0165-5728(01)00423-4 |
| format | Article |
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Altogether, our data indicate that the alteration of CNTFR expression in some MG patients could contribute to the severity of the disease in a subgroup of patients.</description><subject>AChR</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Proteins - pharmacology</subject><subject>Cells, Cultured - drug effects</subject><subject>Cells, Cultured - immunology</subject><subject>Cells, Cultured - metabolism</subject><subject>ciliary neurotrophic factor receptors</subject><subject>CNTFR expression</subject><subject>Female</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle cells</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - immunology</subject><subject>Myasthenia Gravis - metabolism</subject><subject>Receptor, Ciliary Neurotrophic Factor - genetics</subject><subject>Receptors, Cholinergic - genetics</subject><subject>Receptors, Cholinergic - immunology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaCsECwCfiVxVghVpSBVYkH3luNMqFESBzup6N_jPgTLbu7M4sxc6SB0TfADwSR9_AiRxElGxR0m9xhzymJ-gsZEZDQWnJJTNP5DRujC-y-MScJ4fo5GhKQ5Z4yN0Xz20znw3tg2slWkTW2U20QtDM72znYro6NK6d66yIGGbruYNmo2yvcraI2KPp1aG3-JzipVe7g6zAlavsyW09d48T5_mz4vYs1y2sc5F1VVKMgLzgQlIcocFxlJsdCU5ZiJIqNKaFxpwRQmHIMmlWJhx5lSbIJu9287Z78H8L1sjNdQ16oFO3iZUZrkaXBxDCSCcZrRJIDJHtTOeu-gkp0zTXAgCZZb03JnWm41SkzkzrTk4e7mUDAUDZT_Vwe1AXjaAxB0rA046bWBVkNpgsleltYcqfgFtQeNcQ</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Poëa, Sandrine</creator><creator>Guyon, Thierry</creator><creator>Levasseur, Philippe</creator><creator>Berrih-Aknin, Sonia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Expression of ciliary neurotrophic factor receptor in myasthenia gravis</title><author>Poëa, Sandrine ; Guyon, Thierry ; Levasseur, Philippe ; Berrih-Aknin, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-948ffbae9b43821438d90b71608c239038b72a8c0fc83a0140ec1fa33a007aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>AChR</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Proteins - pharmacology</topic><topic>Cells, Cultured - drug effects</topic><topic>Cells, Cultured - immunology</topic><topic>Cells, Cultured - metabolism</topic><topic>ciliary neurotrophic factor receptors</topic><topic>CNTFR expression</topic><topic>Female</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle cells</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - immunology</topic><topic>Myasthenia Gravis - metabolism</topic><topic>Receptor, Ciliary Neurotrophic Factor - genetics</topic><topic>Receptors, Cholinergic - genetics</topic><topic>Receptors, Cholinergic - immunology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poëa, Sandrine</creatorcontrib><creatorcontrib>Guyon, Thierry</creatorcontrib><creatorcontrib>Levasseur, Philippe</creatorcontrib><creatorcontrib>Berrih-Aknin, Sonia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poëa, Sandrine</au><au>Guyon, Thierry</au><au>Levasseur, Philippe</au><au>Berrih-Aknin, Sonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of ciliary neurotrophic factor receptor in myasthenia gravis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>120</volume><issue>1</issue><spage>180</spage><epage>189</epage><pages>180-189</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>In myasthenia gravis, high anti-nicotinic receptor (AChR) antibody titers are not always associated with severity of the disease, suggesting the involvement of other pathological effectors. We showed that ciliary neurotrophic factor receptor (CNTFR) gene expression was higher in muscle biopsy tissue from severely affected MG patients regardless of anti-nAChR antibody titer. This increase was also triggered in vitro by a seric factor from MG patients. CNTFR protein expression was decreased in muscles from seropositive MG patients only.
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| subjects | AChR Adolescent Adult Aged Aged, 80 and over Blood Proteins - pharmacology Cells, Cultured - drug effects Cells, Cultured - immunology Cells, Cultured - metabolism ciliary neurotrophic factor receptors CNTFR expression Female Gene Expression - drug effects Gene Expression - immunology Humans Male Middle Aged Muscle cells Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - metabolism Receptor, Ciliary Neurotrophic Factor - genetics Receptors, Cholinergic - genetics Receptors, Cholinergic - immunology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism |
| title | Expression of ciliary neurotrophic factor receptor in myasthenia gravis |
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