The case for and against intrauterine surgery for myelomeningoceles
The case for and against intrauterine surgery on a myelomeningocele depends on how and in what order the malformations in the spinal cord and brain are thought to develop. If the brain defects arise in the embryonic period and undergo no further change and if the spinal cord is so deformed that it i...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2000-09, Vol.92 (1), p.109-113 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Bannister, Carys M. |
| description | The case for and against intrauterine surgery on a myelomeningocele depends on how and in what order the malformations in the spinal cord and brain are thought to develop. If the brain defects arise in the embryonic period and undergo no further change and if the spinal cord is so deformed that it is functionless from the start, then operative intervention before birth will have no significant effect on the ultimate neurological defect. If, on the other hand, the brain lesions evolve during gestation and the deformed spinal cord has some useful function that can be lost by contact with the amniotic fluid or is susceptible to mechanical damage, then intrauterine surgery may have a beneficial role. Long-term follow-up of children who have already undergone intrauterine surgery should answer whether this novel form of treatment imparts significant benefit to justify the risks it imposes on the mother and fetus. |
| doi_str_mv | 10.1016/S0301-2115(00)00433-4 |
| format | Article |
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If the brain defects arise in the embryonic period and undergo no further change and if the spinal cord is so deformed that it is functionless from the start, then operative intervention before birth will have no significant effect on the ultimate neurological defect. If, on the other hand, the brain lesions evolve during gestation and the deformed spinal cord has some useful function that can be lost by contact with the amniotic fluid or is susceptible to mechanical damage, then intrauterine surgery may have a beneficial role. Long-term follow-up of children who have already undergone intrauterine surgery should answer whether this novel form of treatment imparts significant benefit to justify the risks it imposes on the mother and fetus.</description><subject>Arguments for and against</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Diseases - embryology</subject><subject>Fetal Diseases - surgery</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intrauterine surgery</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Parents - psychology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Spina bifida aperta</subject><subject>Spina Bifida Cystica - embryology</subject><subject>Spina Bifida Cystica - surgery</subject><subject>Surgery (general aspects). 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intrauterine surgery</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Parents - psychology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Spina bifida aperta</topic><topic>Spina Bifida Cystica - embryology</topic><topic>Spina Bifida Cystica - surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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| identifier | ISSN: 0301-2115 |
| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2000-09, Vol.92 (1), p.109-113 |
| issn | 0301-2115 1872-7654 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Arguments for and against Biological and medical sciences Cesarean Section Diseases of mother, fetus and pregnancy Female Fetal Diseases - embryology Fetal Diseases - surgery Gynecology. Andrology. Obstetrics Humans Intrauterine surgery Medical sciences Miscellaneous Parents - psychology Pregnancy Pregnancy. Fetus. Placenta Spina bifida aperta Spina Bifida Cystica - embryology Spina Bifida Cystica - surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome |
| title | The case for and against intrauterine surgery for myelomeningoceles |
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