Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia
OBJECTIVES The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlle...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2000-09, Vol.36 (3), p.746-750 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Mazzone, Antonino Mazzucchelli, Iolanda Vezzoli, Monia Ottini, Elena Auguadro, Carla Serio, Alessandra Falcone, Colomba |
| description | OBJECTIVES
The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia.
BACKGROUND
Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress.
METHODS
The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia.
RESULTS
Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p < 0.005), monocytes (p < 0.001) and granulocytes (p < 0.001).
CONCLUSIONS
These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. |
| doi_str_mv | 10.1016/S0735-1097(00)00778-6 |
| format | Article |
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The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia.
BACKGROUND
Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress.
METHODS
The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia.
RESULTS
Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p < 0.005), monocytes (p < 0.001) and granulocytes (p < 0.001).
CONCLUSIONS
These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(00)00778-6</identifier><identifier>PMID: 10987594</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Activities of Daily Living ; Aged ; Angina Pectoris - etiology ; Angina Pectoris - physiopathology ; Biological and medical sciences ; Cardiology. Vascular system ; Cohort Studies ; Coronary heart disease ; Exercise ; Exercise Test ; Female ; Flow Cytometry ; Granulocytes - metabolism ; Heart ; Humans ; Leukocytes - metabolism ; Male ; Medical sciences ; Middle Aged ; Monocytes - metabolism ; Myocardial Infarction - blood ; Myocardial Infarction - physiopathology ; Receptors, GABA-A - blood</subject><ispartof>Journal of the American College of Cardiology, 2000-09, Vol.36 (3), p.746-750</ispartof><rights>2000 American College of Cardiology</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-a464e0d56359b61fe739d96c3dbed5f56f15371a2e445d5bc63f955513307a1b3</citedby><cites>FETCH-LOGICAL-c424t-a464e0d56359b61fe739d96c3dbed5f56f15371a2e445d5bc63f955513307a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109700007786$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1499402$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10987594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazzone, Antonino</creatorcontrib><creatorcontrib>Mazzucchelli, Iolanda</creatorcontrib><creatorcontrib>Vezzoli, Monia</creatorcontrib><creatorcontrib>Ottini, Elena</creatorcontrib><creatorcontrib>Auguadro, Carla</creatorcontrib><creatorcontrib>Serio, Alessandra</creatorcontrib><creatorcontrib>Falcone, Colomba</creatorcontrib><title>Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>OBJECTIVES
The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia.
BACKGROUND
Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress.
METHODS
The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia.
RESULTS
Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p < 0.005), monocytes (p < 0.001) and granulocytes (p < 0.001).
CONCLUSIONS
These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Angina Pectoris - etiology</subject><subject>Angina Pectoris - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Coronary heart disease</subject><subject>Exercise</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Granulocytes - metabolism</subject><subject>Heart</subject><subject>Humans</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Receptors, GABA-A - blood</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PFTEUhhujkQv6EyRdGKKLkXb6NV0RQkRJSFiI66bTnpHiTDu2cw2XX0_h3gg7Vyc5ed7z8SD0gZIvlFB5_IMoJhpKtPpEyGdClOoa-QqtqBBdw4RWr9HqH7KH9ku5JYTIjuq3aK_2OiU0X6FfF9FlsAU8hrs5QykhRZwGPEMO8w1kO-Ie4n3ywd7DHCLgDA7mJeWCKznC-ndymwUKDhGXMEJc8LRJzuaaGHEo7gamYN-hN4MdC7zf1QP08_zr9dn35vLq28XZ6WXjeMuXxnLJgXgh6we9pAMopr2WjvkevBiEHKhgitoWOBde9E6yQQshKGNEWdqzA3S0nTvn9GcNZTFTPQHG0UZI62JU24pOt6KCYgu6nErJMJg5h8nmjaHEPBo2T4bNoz5DiHkybGTNHe4WrPsJ_IvUVmkFPu4AW5wdh2yjC-WZ41pz0lbsZItBtfE3QDbFBYgOfKiCF-NT-M8lD4iSmbM</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Mazzone, Antonino</creator><creator>Mazzucchelli, Iolanda</creator><creator>Vezzoli, Monia</creator><creator>Ottini, Elena</creator><creator>Auguadro, Carla</creator><creator>Serio, Alessandra</creator><creator>Falcone, Colomba</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia</title><author>Mazzone, Antonino ; Mazzucchelli, Iolanda ; Vezzoli, Monia ; Ottini, Elena ; Auguadro, Carla ; Serio, Alessandra ; Falcone, Colomba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-a464e0d56359b61fe739d96c3dbed5f56f15371a2e445d5bc63f955513307a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Activities of Daily Living</topic><topic>Aged</topic><topic>Angina Pectoris - etiology</topic><topic>Angina Pectoris - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Coronary heart disease</topic><topic>Exercise</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Granulocytes - metabolism</topic><topic>Heart</topic><topic>Humans</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - metabolism</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Receptors, GABA-A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazzone, Antonino</creatorcontrib><creatorcontrib>Mazzucchelli, Iolanda</creatorcontrib><creatorcontrib>Vezzoli, Monia</creatorcontrib><creatorcontrib>Ottini, Elena</creatorcontrib><creatorcontrib>Auguadro, Carla</creatorcontrib><creatorcontrib>Serio, Alessandra</creatorcontrib><creatorcontrib>Falcone, Colomba</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazzone, Antonino</au><au>Mazzucchelli, Iolanda</au><au>Vezzoli, Monia</au><au>Ottini, Elena</au><au>Auguadro, Carla</au><au>Serio, Alessandra</au><au>Falcone, Colomba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>36</volume><issue>3</issue><spage>746</spage><epage>750</epage><pages>746-750</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>OBJECTIVES
The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia.
BACKGROUND
Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress.
METHODS
The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia.
RESULTS
Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p < 0.005), monocytes (p < 0.001) and granulocytes (p < 0.001).
CONCLUSIONS
These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10987594</pmid><doi>10.1016/S0735-1097(00)00778-6</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Activities of Daily Living Aged Angina Pectoris - etiology Angina Pectoris - physiopathology Biological and medical sciences Cardiology. Vascular system Cohort Studies Coronary heart disease Exercise Exercise Test Female Flow Cytometry Granulocytes - metabolism Heart Humans Leukocytes - metabolism Male Medical sciences Middle Aged Monocytes - metabolism Myocardial Infarction - blood Myocardial Infarction - physiopathology Receptors, GABA-A - blood |
| title | Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia |
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