Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections

We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples...

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Veröffentlicht in:Clinical infectious diseases 2001-12, Vol.33 (11), p.1871-1878
Hauptverfasser: Anaissie, Elias J., Kuchar, Robert T., Rex, John H., Francesconi, Andrea, Kasai, Miki, Müller, Frank-Michael C., Mario, Lozano-Chiu, Summerbell, Richard C., Dignani, M. Cecilia, Chanock, Stephen J., Walsh, Thomas J.
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container_end_page 1878
container_issue 11
container_start_page 1871
container_title Clinical infectious diseases
container_volume 33
creator Anaissie, Elias J.
Kuchar, Robert T.
Rex, John H.
Francesconi, Andrea
Kasai, Miki
Müller, Frank-Michael C.
Mario, Lozano-Chiu
Summerbell, Richard C.
Dignani, M. Cecilia
Chanock, Stephen J.
Walsh, Thomas J.
description We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples. Of 92 sink drains tested, 72 (88%) yielded Fusarium solani; 12 (16%) of 71 sink faucet aerators and 2 (8%) of 26 shower heads yielded Fusarium oxysporum. Fusarium solani was isolated from the hospital water tank. Aerosolization of Fusarium species was documented after running the showers. Molecular biotyping revealed multiple distinct genotypes among the isolates from the environment and patients. Eight of 20 patients with F. solani infections had isolates with a molecular match with either an environmental isolate (n = 2) or another patient isolate (n = 6). The time interval between the 2 matched patient-environment isolates pairs was 5 and 11 months, and 2, 4, and 5.5 years for the 3 patient-patient isolate pairs. The water distribution system of a hospital was identified as a reservoir of Fusarium species.
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subjects Air Microbiology
Air sampling
Biological and medical sciences
Cross Infection - epidemiology
Cross Infection - microbiology
DNA, Bacterial - analysis
Drains
Environmental disorders
Fungi
Fusariosis
Fusarium
Fusarium - genetics
Fusarium - isolation & purification
Human mycoses
Humans
Infections
Infectious diseases
Major Articles
Medical sciences
Miscellaneous mycoses
Mycoses
Mycoses - epidemiology
Mycoses - microbiology
Opportunistic Infections - epidemiology
Opportunistic Infections - microbiology
Species
Water Microbiology
Water samples
Water tanks
title Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections
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