Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections
We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples...
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| Veröffentlicht in: | Clinical infectious diseases 2001-12, Vol.33 (11), p.1871-1878 |
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| creator | Anaissie, Elias J. Kuchar, Robert T. Rex, John H. Francesconi, Andrea Kasai, Miki Müller, Frank-Michael C. Mario, Lozano-Chiu Summerbell, Richard C. Dignani, M. Cecilia Chanock, Stephen J. Walsh, Thomas J. |
| description | We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples. Of 92 sink drains tested, 72 (88%) yielded Fusarium solani; 12 (16%) of 71 sink faucet aerators and 2 (8%) of 26 shower heads yielded Fusarium oxysporum. Fusarium solani was isolated from the hospital water tank. Aerosolization of Fusarium species was documented after running the showers. Molecular biotyping revealed multiple distinct genotypes among the isolates from the environment and patients. Eight of 20 patients with F. solani infections had isolates with a molecular match with either an environmental isolate (n = 2) or another patient isolate (n = 6). The time interval between the 2 matched patient-environment isolates pairs was 5 and 11 months, and 2, 4, and 5.5 years for the 3 patient-patient isolate pairs. The water distribution system of a hospital was identified as a reservoir of Fusarium species. |
| doi_str_mv | 10.1086/324501 |
| format | Article |
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Molecular biotyping revealed multiple distinct genotypes among the isolates from the environment and patients. Eight of 20 patients with F. solani infections had isolates with a molecular match with either an environmental isolate (n = 2) or another patient isolate (n = 6). The time interval between the 2 matched patient-environment isolates pairs was 5 and 11 months, and 2, 4, and 5.5 years for the 3 patient-patient isolate pairs. 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Cecilia</creatorcontrib><creatorcontrib>Chanock, Stephen J.</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><title>Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples. Of 92 sink drains tested, 72 (88%) yielded Fusarium solani; 12 (16%) of 71 sink faucet aerators and 2 (8%) of 26 shower heads yielded Fusarium oxysporum. Fusarium solani was isolated from the hospital water tank. Aerosolization of Fusarium species was documented after running the showers. Molecular biotyping revealed multiple distinct genotypes among the isolates from the environment and patients. Eight of 20 patients with F. solani infections had isolates with a molecular match with either an environmental isolate (n = 2) or another patient isolate (n = 6). The time interval between the 2 matched patient-environment isolates pairs was 5 and 11 months, and 2, 4, and 5.5 years for the 3 patient-patient isolate pairs. The water distribution system of a hospital was identified as a reservoir of Fusarium species.</description><subject>Air Microbiology</subject><subject>Air sampling</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>DNA, Bacterial - analysis</subject><subject>Drains</subject><subject>Environmental disorders</subject><subject>Fungi</subject><subject>Fusariosis</subject><subject>Fusarium</subject><subject>Fusarium - genetics</subject><subject>Fusarium - isolation & purification</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Miscellaneous mycoses</subject><subject>Mycoses</subject><subject>Mycoses - epidemiology</subject><subject>Mycoses - microbiology</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - microbiology</subject><subject>Species</subject><subject>Water Microbiology</subject><subject>Water samples</subject><subject>Water tanks</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEohfgCRAyi7IL2HFiO-yGoe1UDBQoN7GxHMeZcUni4OOoDM_Dg-JRRp0VQl7Y0vnOd471J8kjgp8TLNgLmuUFJneSQ1JQnrKiJHfjGxcizQUVB8kRwDXGhAhc3E8OCGFllpXlYfLnbATlrQMLaAbgtFXB1OjGhjV6r8LarUxvNZqosUNXg9HWAJq71vX2twrW9cg1SKGFg8EG1aKv0eDR1QaC6V6iGXpnbqLKq9quOtQ4j8LaoNPB1qaz0bLabPsvh8H5MPYWQhz31rU1uugbo7d-eJDca1QL5uHuPk4-n51-mi_S5eX5xXy2THWekZDyMounopznJNd11YiqJA1jDTcFZdpwo4ViGc15rjTXFVesxiQvYjfXmS7ocfJs8g7e_RwNBNlZ0KZtVW_cCJJnWSE4pv8FichzQTjZg9o7AG8aOXjbKb-RBMttcHIKLoJPdsax6ky9x3ZJReBkByjQqm286rWFPRe_TAnZrvZ04tw4_HvY44m5huD8LRV3zkrMYzmdyjEM8-u2rPwPyTjlhVx8-y7Z-fL1qy8fP8g39C83ZcQt</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Anaissie, Elias J.</creator><creator>Kuchar, Robert T.</creator><creator>Rex, John H.</creator><creator>Francesconi, Andrea</creator><creator>Kasai, Miki</creator><creator>Müller, Frank-Michael C.</creator><creator>Mario, Lozano-Chiu</creator><creator>Summerbell, Richard C.</creator><creator>Dignani, M. 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Cecilia</creatorcontrib><creatorcontrib>Chanock, Stephen J.</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anaissie, Elias J.</au><au>Kuchar, Robert T.</au><au>Rex, John H.</au><au>Francesconi, Andrea</au><au>Kasai, Miki</au><au>Müller, Frank-Michael C.</au><au>Mario, Lozano-Chiu</au><au>Summerbell, Richard C.</au><au>Dignani, M. Cecilia</au><au>Chanock, Stephen J.</au><au>Walsh, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>33</volume><issue>11</issue><spage>1871</spage><epage>1878</epage><pages>1871-1878</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>We sought the reservoir of Fusarium species in a hospital with cases of known fusarial infections. Cultures of samples from patients and the environment were performed and evaluated for relatedness by use of molecular methods. Fusarium species was recovered from 162 (57%) of 283 water system samples. Of 92 sink drains tested, 72 (88%) yielded Fusarium solani; 12 (16%) of 71 sink faucet aerators and 2 (8%) of 26 shower heads yielded Fusarium oxysporum. Fusarium solani was isolated from the hospital water tank. Aerosolization of Fusarium species was documented after running the showers. Molecular biotyping revealed multiple distinct genotypes among the isolates from the environment and patients. Eight of 20 patients with F. solani infections had isolates with a molecular match with either an environmental isolate (n = 2) or another patient isolate (n = 6). The time interval between the 2 matched patient-environment isolates pairs was 5 and 11 months, and 2, 4, and 5.5 years for the 3 patient-patient isolate pairs. The water distribution system of a hospital was identified as a reservoir of Fusarium species.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11692299</pmid><doi>10.1086/324501</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Air Microbiology Air sampling Biological and medical sciences Cross Infection - epidemiology Cross Infection - microbiology DNA, Bacterial - analysis Drains Environmental disorders Fungi Fusariosis Fusarium Fusarium - genetics Fusarium - isolation & purification Human mycoses Humans Infections Infectious diseases Major Articles Medical sciences Miscellaneous mycoses Mycoses Mycoses - epidemiology Mycoses - microbiology Opportunistic Infections - epidemiology Opportunistic Infections - microbiology Species Water Microbiology Water samples Water tanks |
| title | Fusariosis Associated with Pathogenic Fusarium Species Colonization of a Hospital Water System: A New Paradigm for the Epidemiology of Opportunistic Mold Infections |
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