The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis
The term "aspergillosis" comprises several categories of infection: invasive aspergillosis; chronic necrotizing aspergillosis; aspergilloma, or fungus ball; and allergic bronchopulmonary aspergillosis. In 24 medical centers, we examined the impact of a culture positive for Aspergillus spec...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2001-12, Vol.33 (11), p.1824-1833 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1833 |
|---|---|
| container_issue | 11 |
| container_start_page | 1824 |
| container_title | Clinical infectious diseases |
| container_volume | 33 |
| creator | Perfect, J. R. Cox, G. M. Lee, J. Y. Kauffman, C. A. de Repentigny, L. Chapman, S. W. Morrison, V. A. Pappas, P. Hiemenz, J. W. Stevens, D. A. |
| description | The term "aspergillosis" comprises several categories of infection: invasive aspergillosis; chronic necrotizing aspergillosis; aspergilloma, or fungus ball; and allergic bronchopulmonary aspergillosis. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. Most Aspergillus culture isolates from nonsterile body sites do not represent disease. However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. When such risk factors as human immunodeficiency virus infection (20%), solid-organ transplantation (20%), corticosteroid use (20%), or an underlying pulmonary disease (10%) are associated with a positive culture result, clinical judgment and better diagnostic tests are necessary. The management of invasive aspergillosis remains suboptimal: only 38% of patients are alive 3 months after diagnosis. Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes. |
| doi_str_mv | 10.1086/323900 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72258383</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4482900</jstor_id><oup_id>10.1086/323900</oup_id><sourcerecordid>4482900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-c51edf8eb03e82200a9fcb197ecab8c9bd6823318053e94c2dcf464d8c5503523</originalsourceid><addsrcrecordid>eNqF0M1u1DAUBWALUdFS4AkqFBZ0l-LfxGE3jEqnahGLDhJiYxznpnXxjINvUtG3b0YZddQF6srWPZ-urUPIO0ZPGNXFJ8FFRekLcsCUKPNCVezleKdK51ILvU9eI95Sypim6hXZZ6yoOK_EAfm9vIHsfNVZ12exzeZD6Ic0TjAG2_u43gxn2EG69iEMmF114Dzg52yWLSJ2vrch_2IRmuxqSHdw_8RH9PiG7LU2ILzdnofkx9fT5XyRX34_O5_PLnMnOetzpxg0rYaaCtCcU2qr1tWsKsHZWruqbgrNhdj8X0AlHW9cKwvZaKcUFYqLQ3I87e1S_DsA9mbl0UEIdg1xQFNyrsYmxLOQaSlLWsoddCkiJmhNl_zKpnvDqNmUbqbSR_h-u3GoV9Ds2LblEXzcAovOhjbZtfO4c5JJwWgxug-Ti0P3_8eOJnOLfUyPSkrNpzifYo89_HuMbfpjilKUyix-_jJlQb-dLeiFWYoHZsCqPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18447074</pqid></control><display><type>article</type><title>The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Perfect, J. R. ; Cox, G. M. ; Lee, J. Y. ; Kauffman, C. A. ; de Repentigny, L. ; Chapman, S. W. ; Morrison, V. A. ; Pappas, P. ; Hiemenz, J. W. ; Stevens, D. A.</creator><creatorcontrib>Perfect, J. R. ; Cox, G. M. ; Lee, J. Y. ; Kauffman, C. A. ; de Repentigny, L. ; Chapman, S. W. ; Morrison, V. A. ; Pappas, P. ; Hiemenz, J. W. ; Stevens, D. A. ; Mycoses Study Group ; the Mycoses Study Group</creatorcontrib><description>The term "aspergillosis" comprises several categories of infection: invasive aspergillosis; chronic necrotizing aspergillosis; aspergilloma, or fungus ball; and allergic bronchopulmonary aspergillosis. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. Most Aspergillus culture isolates from nonsterile body sites do not represent disease. However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. When such risk factors as human immunodeficiency virus infection (20%), solid-organ transplantation (20%), corticosteroid use (20%), or an underlying pulmonary disease (10%) are associated with a positive culture result, clinical judgment and better diagnostic tests are necessary. The management of invasive aspergillosis remains suboptimal: only 38% of patients are alive 3 months after diagnosis. Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/323900</identifier><identifier>PMID: 11692293</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Allergic bronchopulmonary aspergillosis ; Aspergillosis ; Aspergillosis - diagnosis ; Aspergillosis - microbiology ; Aspergillosis - mortality ; Aspergillus ; Aspergillus - isolation & purification ; Biological and medical sciences ; Chronic diseases ; Cross Infection - diagnosis ; Cross Infection - microbiology ; Cross Infection - mortality ; Epidemiology ; Female ; Fungal infections ; General aspects ; Health outcomes ; Humans ; Infections ; Infectious diseases ; Lung diseases ; Major Articles ; Male ; Medical sciences ; Middle Aged ; Mycoses ; Opportunistic Infections - diagnosis ; Opportunistic Infections - microbiology ; Opportunistic Infections - mortality ; Predisposing factors ; Risk Factors</subject><ispartof>Clinical infectious diseases, 2001-12, Vol.33 (11), p.1824-1833</ispartof><rights>Copyright 2001 The Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-c51edf8eb03e82200a9fcb197ecab8c9bd6823318053e94c2dcf464d8c5503523</citedby><cites>FETCH-LOGICAL-c421t-c51edf8eb03e82200a9fcb197ecab8c9bd6823318053e94c2dcf464d8c5503523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4482900$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4482900$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14143106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11692293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perfect, J. R.</creatorcontrib><creatorcontrib>Cox, G. M.</creatorcontrib><creatorcontrib>Lee, J. Y.</creatorcontrib><creatorcontrib>Kauffman, C. A.</creatorcontrib><creatorcontrib>de Repentigny, L.</creatorcontrib><creatorcontrib>Chapman, S. W.</creatorcontrib><creatorcontrib>Morrison, V. A.</creatorcontrib><creatorcontrib>Pappas, P.</creatorcontrib><creatorcontrib>Hiemenz, J. W.</creatorcontrib><creatorcontrib>Stevens, D. A.</creatorcontrib><creatorcontrib>Mycoses Study Group</creatorcontrib><creatorcontrib>the Mycoses Study Group</creatorcontrib><title>The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>The term "aspergillosis" comprises several categories of infection: invasive aspergillosis; chronic necrotizing aspergillosis; aspergilloma, or fungus ball; and allergic bronchopulmonary aspergillosis. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. Most Aspergillus culture isolates from nonsterile body sites do not represent disease. However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. When such risk factors as human immunodeficiency virus infection (20%), solid-organ transplantation (20%), corticosteroid use (20%), or an underlying pulmonary disease (10%) are associated with a positive culture result, clinical judgment and better diagnostic tests are necessary. The management of invasive aspergillosis remains suboptimal: only 38% of patients are alive 3 months after diagnosis. Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes.</description><subject>Allergic bronchopulmonary aspergillosis</subject><subject>Aspergillosis</subject><subject>Aspergillosis - diagnosis</subject><subject>Aspergillosis - microbiology</subject><subject>Aspergillosis - mortality</subject><subject>Aspergillus</subject><subject>Aspergillus - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Chronic diseases</subject><subject>Cross Infection - diagnosis</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - mortality</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fungal infections</subject><subject>General aspects</subject><subject>Health outcomes</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lung diseases</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses</subject><subject>Opportunistic Infections - diagnosis</subject><subject>Opportunistic Infections - microbiology</subject><subject>Opportunistic Infections - mortality</subject><subject>Predisposing factors</subject><subject>Risk Factors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1u1DAUBWALUdFS4AkqFBZ0l-LfxGE3jEqnahGLDhJiYxznpnXxjINvUtG3b0YZddQF6srWPZ-urUPIO0ZPGNXFJ8FFRekLcsCUKPNCVezleKdK51ILvU9eI95Sypim6hXZZ6yoOK_EAfm9vIHsfNVZ12exzeZD6Ic0TjAG2_u43gxn2EG69iEMmF114Dzg52yWLSJ2vrch_2IRmuxqSHdw_8RH9PiG7LU2ILzdnofkx9fT5XyRX34_O5_PLnMnOetzpxg0rYaaCtCcU2qr1tWsKsHZWruqbgrNhdj8X0AlHW9cKwvZaKcUFYqLQ3I87e1S_DsA9mbl0UEIdg1xQFNyrsYmxLOQaSlLWsoddCkiJmhNl_zKpnvDqNmUbqbSR_h-u3GoV9Ds2LblEXzcAovOhjbZtfO4c5JJwWgxug-Ti0P3_8eOJnOLfUyPSkrNpzifYo89_HuMbfpjilKUyix-_jJlQb-dLeiFWYoHZsCqPQ</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Perfect, J. R.</creator><creator>Cox, G. M.</creator><creator>Lee, J. Y.</creator><creator>Kauffman, C. A.</creator><creator>de Repentigny, L.</creator><creator>Chapman, S. W.</creator><creator>Morrison, V. A.</creator><creator>Pappas, P.</creator><creator>Hiemenz, J. W.</creator><creator>Stevens, D. A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis</title><author>Perfect, J. R. ; Cox, G. M. ; Lee, J. Y. ; Kauffman, C. A. ; de Repentigny, L. ; Chapman, S. W. ; Morrison, V. A. ; Pappas, P. ; Hiemenz, J. W. ; Stevens, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-c51edf8eb03e82200a9fcb197ecab8c9bd6823318053e94c2dcf464d8c5503523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Allergic bronchopulmonary aspergillosis</topic><topic>Aspergillosis</topic><topic>Aspergillosis - diagnosis</topic><topic>Aspergillosis - microbiology</topic><topic>Aspergillosis - mortality</topic><topic>Aspergillus</topic><topic>Aspergillus - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Chronic diseases</topic><topic>Cross Infection - diagnosis</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - mortality</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fungal infections</topic><topic>General aspects</topic><topic>Health outcomes</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lung diseases</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycoses</topic><topic>Opportunistic Infections - diagnosis</topic><topic>Opportunistic Infections - microbiology</topic><topic>Opportunistic Infections - mortality</topic><topic>Predisposing factors</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perfect, J. R.</creatorcontrib><creatorcontrib>Cox, G. M.</creatorcontrib><creatorcontrib>Lee, J. Y.</creatorcontrib><creatorcontrib>Kauffman, C. A.</creatorcontrib><creatorcontrib>de Repentigny, L.</creatorcontrib><creatorcontrib>Chapman, S. W.</creatorcontrib><creatorcontrib>Morrison, V. A.</creatorcontrib><creatorcontrib>Pappas, P.</creatorcontrib><creatorcontrib>Hiemenz, J. W.</creatorcontrib><creatorcontrib>Stevens, D. A.</creatorcontrib><creatorcontrib>Mycoses Study Group</creatorcontrib><creatorcontrib>the Mycoses Study Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perfect, J. R.</au><au>Cox, G. M.</au><au>Lee, J. Y.</au><au>Kauffman, C. A.</au><au>de Repentigny, L.</au><au>Chapman, S. W.</au><au>Morrison, V. A.</au><au>Pappas, P.</au><au>Hiemenz, J. W.</au><au>Stevens, D. A.</au><aucorp>Mycoses Study Group</aucorp><aucorp>the Mycoses Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>33</volume><issue>11</issue><spage>1824</spage><epage>1833</epage><pages>1824-1833</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>The term "aspergillosis" comprises several categories of infection: invasive aspergillosis; chronic necrotizing aspergillosis; aspergilloma, or fungus ball; and allergic bronchopulmonary aspergillosis. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. Most Aspergillus culture isolates from nonsterile body sites do not represent disease. However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. When such risk factors as human immunodeficiency virus infection (20%), solid-organ transplantation (20%), corticosteroid use (20%), or an underlying pulmonary disease (10%) are associated with a positive culture result, clinical judgment and better diagnostic tests are necessary. The management of invasive aspergillosis remains suboptimal: only 38% of patients are alive 3 months after diagnosis. Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11692293</pmid><doi>10.1086/323900</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2001-12, Vol.33 (11), p.1824-1833 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72258383 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Allergic bronchopulmonary aspergillosis Aspergillosis Aspergillosis - diagnosis Aspergillosis - microbiology Aspergillosis - mortality Aspergillus Aspergillus - isolation & purification Biological and medical sciences Chronic diseases Cross Infection - diagnosis Cross Infection - microbiology Cross Infection - mortality Epidemiology Female Fungal infections General aspects Health outcomes Humans Infections Infectious diseases Lung diseases Major Articles Male Medical sciences Middle Aged Mycoses Opportunistic Infections - diagnosis Opportunistic Infections - microbiology Opportunistic Infections - mortality Predisposing factors Risk Factors |
| title | The Impact of Culture Isolation of Aspergillus Species: A Hospital-Based Survey of Aspergillosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T06%3A39%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Culture%20Isolation%20of%20Aspergillus%20Species:%20A%20Hospital-Based%20Survey%20of%20Aspergillosis&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Perfect,%20J.%20R.&rft.aucorp=Mycoses%20Study%20Group&rft.date=2001-12-01&rft.volume=33&rft.issue=11&rft.spage=1824&rft.epage=1833&rft.pages=1824-1833&rft.issn=1058-4838&rft.eissn=1537-6591&rft.coden=CIDIEL&rft_id=info:doi/10.1086/323900&rft_dat=%3Cjstor_proqu%3E4482900%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18447074&rft_id=info:pmid/11692293&rft_jstor_id=4482900&rft_oup_id=10.1086/323900&rfr_iscdi=true |