Cyclic Adenosine Monophosphate Inhibits Quinolone Alkaloid Evocarpine‐Induced Apoptosis via Activation of Protein Kinase A in Human Leukaemic HL‐60 Cells
: Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose‐ and time‐dependent manners. We investigated the involvement of protein kinase A during the evocarpine‐induced apoptotic cell d...
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| Veröffentlicht in: | Pharmacology & toxicology 2000-07, Vol.87 (1), p.1-5 |
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| creator | Kim, Na‐Young Pae, Hyun‐Ock Kang, Tai‐Hyun Kim, Youn‐Chul Lee, Ho‐Sub Chung, Hun‐Taeg |
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Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose‐ and time‐dependent manners. We investigated the involvement of protein kinase A during the evocarpine‐induced apoptotic cell death. Evocarpine‐induced apoptosis was markedly inhibited by treatment of the cells with dibutyryl‐cyclic adenosine monophosphate. Similar results were obtained with other commonly used cyclic adenosine monophosphate analogues, chlorophenylthio‐cyclic adenosine monophosphate and the intracellular cyclic adenosine monophosphate‐elevating agent, forskolin. In contrast, pretreatment of HL‐60 cells with KT5720, an inhibitor of cyclic adenosine monophosphate‐dependent protein kinase A, abrogated the protective effects of cyclic adenosine monophosphate analogues and forskolin on evocrpine‐induced apoptosis. These findings suggest that cyclic adenosine monophosphate‐dependent activation of protein kinase A plays a crucial role in protecting HL‐60 cells from the evocarpine‐induced apoptotic cell death. |
| doi_str_mv | 10.1111/j.0901-9928.2000.870101.x |
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Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose‐ and time‐dependent manners. We investigated the involvement of protein kinase A during the evocarpine‐induced apoptotic cell death. Evocarpine‐induced apoptosis was markedly inhibited by treatment of the cells with dibutyryl‐cyclic adenosine monophosphate. Similar results were obtained with other commonly used cyclic adenosine monophosphate analogues, chlorophenylthio‐cyclic adenosine monophosphate and the intracellular cyclic adenosine monophosphate‐elevating agent, forskolin. In contrast, pretreatment of HL‐60 cells with KT5720, an inhibitor of cyclic adenosine monophosphate‐dependent protein kinase A, abrogated the protective effects of cyclic adenosine monophosphate analogues and forskolin on evocrpine‐induced apoptosis. These findings suggest that cyclic adenosine monophosphate‐dependent activation of protein kinase A plays a crucial role in protecting HL‐60 cells from the evocarpine‐induced apoptotic cell death.</description><identifier>ISSN: 0901-9928</identifier><identifier>EISSN: 1600-0773</identifier><identifier>DOI: 10.1111/j.0901-9928.2000.870101.x</identifier><identifier>PMID: 10987208</identifier><identifier>CODEN: PHTOEH</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Ageing, cell death ; Apoptosis - drug effects ; Biological and medical sciences ; Cell physiology ; Cyclic AMP - analogs & derivatives ; Cyclic AMP - pharmacology ; Cyclic AMP-Dependent Protein Kinases - drug effects ; DNA Fragmentation - drug effects ; Electrophoresis, Agar Gel ; Fundamental and applied biological sciences. Psychology ; HL-60 Cells ; Humans ; Molecular and cellular biology ; Quinolones - antagonists & inhibitors</subject><ispartof>Pharmacology & toxicology, 2000-07, Vol.87 (1), p.1-5</ispartof><rights>2000 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5171-56e515fb7555777bc105f9367fb72b08054d9a26d8f2bc762a3d765481d371f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.0901-9928.2000.870101.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.0901-9928.2000.870101.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1446022$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10987208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Na‐Young</creatorcontrib><creatorcontrib>Pae, Hyun‐Ock</creatorcontrib><creatorcontrib>Kang, Tai‐Hyun</creatorcontrib><creatorcontrib>Kim, Youn‐Chul</creatorcontrib><creatorcontrib>Lee, Ho‐Sub</creatorcontrib><creatorcontrib>Chung, Hun‐Taeg</creatorcontrib><title>Cyclic Adenosine Monophosphate Inhibits Quinolone Alkaloid Evocarpine‐Induced Apoptosis via Activation of Protein Kinase A in Human Leukaemic HL‐60 Cells</title><title>Pharmacology & toxicology</title><addtitle>Pharmacol Toxicol</addtitle><description>:
Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose‐ and time‐dependent manners. We investigated the involvement of protein kinase A during the evocarpine‐induced apoptotic cell death. Evocarpine‐induced apoptosis was markedly inhibited by treatment of the cells with dibutyryl‐cyclic adenosine monophosphate. Similar results were obtained with other commonly used cyclic adenosine monophosphate analogues, chlorophenylthio‐cyclic adenosine monophosphate and the intracellular cyclic adenosine monophosphate‐elevating agent, forskolin. In contrast, pretreatment of HL‐60 cells with KT5720, an inhibitor of cyclic adenosine monophosphate‐dependent protein kinase A, abrogated the protective effects of cyclic adenosine monophosphate analogues and forskolin on evocrpine‐induced apoptosis. These findings suggest that cyclic adenosine monophosphate‐dependent activation of protein kinase A plays a crucial role in protecting HL‐60 cells from the evocarpine‐induced apoptotic cell death.</description><subject>Ageing, cell death</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cyclic AMP - analogs & derivatives</subject><subject>Cyclic AMP - pharmacology</subject><subject>Cyclic AMP-Dependent Protein Kinases - drug effects</subject><subject>DNA Fragmentation - drug effects</subject><subject>Electrophoresis, Agar Gel</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Quinolones - antagonists & inhibitors</subject><issn>0901-9928</issn><issn>1600-0773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9u1DAYxSMEoqPSKyAjIXYJn504dpYhKsyIQRSprC3HcTRuEzvEybSz4whcgMtxEhxlBCzxxn_0e89P34uiVxgSHNbbuwQKwHFREJ4QAEg4Aww4eXwSbXAOEANj6dNo84e6iK68NzWklHGMs_x5dIGh4IwA30Q_q5PqjEJlo63zxmr0yVk3HJwfDnLSaGcPpjaTR19mY13nAlB297JzpkHXR6fkOATRr-8_draZlW5QObhhCk4eHY1EpZrMUU7GWeRadDO6SRuLPhorfTBC4byde2nRXs_3UvchyHYfzHJAle46_yJ61srO66vzfhl9fX99W23j_ecPu6rcx4pihmOaa4ppWzNKKWOsVhhoW6Q5C0-kBg40awpJ8oa3pFYsJzJtWE4zjpuU4Zanl9Gb1XcY3bdZ-0n0xquQQFrtZi8YIZQTTgJYrKAanfejbsUwml6OJ4FBLPWIO7EMXiyDF0s9Yq1HPAbty_Mnc93r5h_lWkYAXp8B6ZXs2lFaZfxfLstyIEuGcsUeTKdP_x9AvKtubtdL-hvp8K5H</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Kim, Na‐Young</creator><creator>Pae, Hyun‐Ock</creator><creator>Kang, Tai‐Hyun</creator><creator>Kim, Youn‐Chul</creator><creator>Lee, Ho‐Sub</creator><creator>Chung, Hun‐Taeg</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>Cyclic Adenosine Monophosphate Inhibits Quinolone Alkaloid Evocarpine‐Induced Apoptosis via Activation of Protein Kinase A in Human Leukaemic HL‐60 Cells</title><author>Kim, Na‐Young ; Pae, Hyun‐Ock ; Kang, Tai‐Hyun ; Kim, Youn‐Chul ; Lee, Ho‐Sub ; Chung, Hun‐Taeg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5171-56e515fb7555777bc105f9367fb72b08054d9a26d8f2bc762a3d765481d371f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Ageing, cell death</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cyclic AMP - analogs & derivatives</topic><topic>Cyclic AMP - pharmacology</topic><topic>Cyclic AMP-Dependent Protein Kinases - drug effects</topic><topic>DNA Fragmentation - drug effects</topic><topic>Electrophoresis, Agar Gel</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Quinolones - antagonists & inhibitors</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Na‐Young</creatorcontrib><creatorcontrib>Pae, Hyun‐Ock</creatorcontrib><creatorcontrib>Kang, Tai‐Hyun</creatorcontrib><creatorcontrib>Kim, Youn‐Chul</creatorcontrib><creatorcontrib>Lee, Ho‐Sub</creatorcontrib><creatorcontrib>Chung, Hun‐Taeg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Na‐Young</au><au>Pae, Hyun‐Ock</au><au>Kang, Tai‐Hyun</au><au>Kim, Youn‐Chul</au><au>Lee, Ho‐Sub</au><au>Chung, Hun‐Taeg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic Adenosine Monophosphate Inhibits Quinolone Alkaloid Evocarpine‐Induced Apoptosis via Activation of Protein Kinase A in Human Leukaemic HL‐60 Cells</atitle><jtitle>Pharmacology & toxicology</jtitle><addtitle>Pharmacol Toxicol</addtitle><date>2000-07</date><risdate>2000</risdate><volume>87</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0901-9928</issn><eissn>1600-0773</eissn><coden>PHTOEH</coden><abstract>:
Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose‐ and time‐dependent manners. We investigated the involvement of protein kinase A during the evocarpine‐induced apoptotic cell death. Evocarpine‐induced apoptosis was markedly inhibited by treatment of the cells with dibutyryl‐cyclic adenosine monophosphate. Similar results were obtained with other commonly used cyclic adenosine monophosphate analogues, chlorophenylthio‐cyclic adenosine monophosphate and the intracellular cyclic adenosine monophosphate‐elevating agent, forskolin. In contrast, pretreatment of HL‐60 cells with KT5720, an inhibitor of cyclic adenosine monophosphate‐dependent protein kinase A, abrogated the protective effects of cyclic adenosine monophosphate analogues and forskolin on evocrpine‐induced apoptosis. These findings suggest that cyclic adenosine monophosphate‐dependent activation of protein kinase A plays a crucial role in protecting HL‐60 cells from the evocarpine‐induced apoptotic cell death.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>10987208</pmid><doi>10.1111/j.0901-9928.2000.870101.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ageing, cell death Apoptosis - drug effects Biological and medical sciences Cell physiology Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - drug effects DNA Fragmentation - drug effects Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology HL-60 Cells Humans Molecular and cellular biology Quinolones - antagonists & inhibitors |
| title | Cyclic Adenosine Monophosphate Inhibits Quinolone Alkaloid Evocarpine‐Induced Apoptosis via Activation of Protein Kinase A in Human Leukaemic HL‐60 Cells |
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