Mitochondrial Dysfunction in Cybrid Lines Expressing Mitochondrial Genes from Patients with Progressive Supranuclear Palsy

: Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder of unknown etiology. We hypothesized that mitochondrial DNA (mtDNA) aberration could occur in this disease and contribute to its pathogenesis. To address this we created transmitochondrial cytoplasmic hybrid (cybrid) cel...

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Veröffentlicht in:	Journal of neurochemistry 2000-10, Vol.75 (4), p.1681-1684
Hauptverfasser:	Swerdlow, R. H., Golbe, L. I., Parks, J. K., Cassarino, D. S., Binder, D. R., Grawey, A. E., Litvan, I., Bennett, J. P., Wooten, G. F., Parker, W. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antioxidants - metabolism Biological and medical sciences Blood Platelets - cytology Catalase - metabolism Cell Fusion Cybrids Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA, Mitochondrial - genetics Electron Transport - genetics Electron Transport Complex I Electron Transport Complex IV - metabolism Female Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Humans Hybrid Cells - cytology Hybrid Cells - metabolism Male Medical sciences Mitochondria Mitochondria - enzymology Mitochondria - genetics NADH, NADPH Oxidoreductases - metabolism Neurology Oxidative stress Oxidative Stress - genetics Progressive supranuclear palsy Superoxide Dismutase - metabolism Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - etiology Supranuclear Palsy, Progressive - genetics Tumor Cells, Cultured
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