Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors

Allele losses from chromosome 17 are common in sporadic ovarian tumors. Previously, we reported high rates of LOH (up to 70%) from 17q25 at the marker THH59 in a bank of malignant ovarian tumors. We have extended this study to 70 tumors with 17 markers from the long arm of chromosome 17. In most cas...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-09, Vol.60 (17), p.4729-4734
Hauptverfasser:	Russell, S E, McIlhatton, M A, Burrows, J F, Donaghy, P G, Chanduloy, S, Petty, E M, Kalikin, L M, Church, S W, McIlroy, S, Harkin, D P, Keilty, G W, Cranston, A N, Weissenbach, J, Hickey, I, Johnston, P G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence chromosome 17 Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 17 Contig Mapping DNA Mutational Analysis DNA, Complementary - genetics DNA, Complementary - isolation & purification DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Female Genes, Tumor Suppressor GTP Phosphohydrolases GTP-Binding Proteins - genetics Humans Loss of Heterozygosity Molecular Sequence Data Ovarian Neoplasms - genetics septin gene Septins Sequence Homology, Amino Acid
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