The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat

The purpose of this study was to determine if changes in nuclear protein binding of hepatocyte nuclear factor 1 (HNF‐1) occur after lipopolysaccharide (LPS) administration. In addition, the time‐course of alterations in CYP2E1 regulation were evaluated. Rats were injected with 2.0 mg LPS and euthani...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2001-10, Vol.53 (10), p.1365-1371
Hauptverfasser:	Roe, Amy L., Poloyac, Samuel M., Howard, Georgette, Shedlofsky, Steven I., Blouin, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Nucleus - chemistry Cytochrome P-450 CYP2E1 - biosynthesis DNA-Binding Proteins Electrophoretic Mobility Shift Assay Endotoxins - pharmacology Enzyme-Linked Immunosorbent Assay Gene Expression Regulation, Enzymologic - drug effects Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Lipopolysaccharides - pharmacology Liver - drug effects Liver - enzymology Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Nuclear Proteins - metabolism Protein Binding Rats Rats, Sprague-Dawley Transcription Factors - metabolism
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