Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation
To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin‐producing β‐cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransp...
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| Veröffentlicht in: | Transplant international 2001-09, Vol.14 (5), p.343-345 |
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| container_title | Transplant international |
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| creator | Cretin, N. Fournier, B. Bühler, L. Morel, P. Caulfield, A. Philippe, J. Becker, C. |
| description | To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin‐producing β‐cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long‐term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin‐independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients. |
| doi_str_mv | 10.1111/j.1432-2277.2001.tb00069.x |
| format | Article |
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Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long‐term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin‐independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2001.tb00069.x</identifier><identifier>PMID: 11692219</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; C-Peptide - blood ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - surgery ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Follow-Up Studies ; Glucagon ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Islet allotransplantation ; Islets of Langerhans Transplantation - physiology ; Management. Various non-drug treatments. 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Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long‐term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin‐independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>C-Peptide - blood</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - surgery</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucagon</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - therapeutic use</subject><subject>Islet allotransplantation</subject><subject>Islets of Langerhans Transplantation - physiology</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Reference Values</subject><subject>Time Factors</subject><subject>Transplantation, Homologous</subject><subject>Type I diabetes</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU-LFDEQxYMo7rj6FSQIeuu2Ukk6HQ-CLP4ZWBBkPYeanrRkyCRjp5vd9dPb7TTuUaxD6pBfVT3eY-yVgFrM9fZQCyWxQjSmRgBRjzsAaGx994ht_n49ZhuwUlXQGnXBnpVymCFsNTxlF0I0FlHYDTtsU5liSDykvT_5-Umd55T2POXhSDH8ojHkxHPP80CR_4hTl4vnY45-oIUdfRk59aMfeCjRj7zzMXKKMY8zUE6R0vhnx3P2pKdY_Iu1X7Lvnz7eXH2prr9-3l59uK46KUFWsmmgb61ptSbVKtgjdgJwpw1gg0CdsuR7Uhagt9gLaJQG2lmjOzRWk7xkb857T0P-Oc3q3DGURRQln6fiDKI2aPQ_QdEqqdtmAd-dwW7IpQy-d6chHGm4dwLcEok7uMV3t_julkjcGom7m4dfrlem3dHvH0bXDGbg9QpQ6Sj2i62hPHBKCJStmbn3Z-42RH__HxLczbetVFL-BhEMqQU</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Cretin, N.</creator><creator>Fournier, B.</creator><creator>Bühler, L.</creator><creator>Morel, P.</creator><creator>Caulfield, A.</creator><creator>Philippe, J.</creator><creator>Becker, C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation</title><author>Cretin, N. ; Fournier, B. ; Bühler, L. ; Morel, P. ; Caulfield, A. ; Philippe, J. ; Becker, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3303-3660f897855a4840d22c102b5702620ac49aefa4900f92f106450ab975c2795a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>C-Peptide - blood</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - surgery</topic><topic>Diabetes. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism C-Peptide - blood Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - surgery Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Follow-Up Studies Glucagon Glucose Tolerance Test Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Islet allotransplantation Islets of Langerhans Transplantation - physiology Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Reference Values Time Factors Transplantation, Homologous Type I diabetes |
| title | Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation |
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