Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids

N,N-Dicinnamyl, N-benzyl- N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10–50 μM) affinity for EBP; ‘dimerization’ of the most potent analogues by coupling with linear...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-09, Vol.10 (17), p.1995-1999
Hauptverfasser:	Connolly, Peter J, Wetter, Steven K, Murray, William V, Johnson, Dana L, McMahon, Frank J, Farrell, Francis X, Tullai, Jennifer, Jolliffe, Linda K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemical synthesis Amino Acids - metabolism Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Dimerization Medical sciences Pharmacology. Drug treatments Receptors, Erythropoietin - metabolism
Online-Zugang:	Volltext
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