Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits

We investigated the effects of administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and bimakalim), and a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) prior to and during coronary occlusion as well as prior to and during post-ischemic rep...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2001-11, Vol.364 (5), p.383-396
Hauptverfasser:	Das, B, Sarkar, C, Karanth, K S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - therapeutic use Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - etiology Benzopyrans - therapeutic use Blood Gas Analysis Coronary Disease - drug therapy Decanoic Acids - pharmacology Dihydropyridines - therapeutic use Drug Combinations Hemodynamics - drug effects Hydroxy Acids - pharmacology Male Myocardial Ischemia - drug therapy Nicorandil - therapeutic use Potassium Channels - drug effects Rabbits Reperfusion Injury - drug therapy Survival Rate
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