Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane
Some novel 1,2-bis(s-triazolo[3,4 b][1,3,4]thiadiazino-3-yl)ethane ( 4– 7); 1,2-bis(s-triazolo[3,4 b][1,3,4]thiadiazol-3-yl)ethane ( 16a, b) and 1,2-bis(s-triazolo[3,4 b][1,3,4]thiadiazepino-3-yl)ethane ( 17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane ( 3) with...
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| Veröffentlicht in: | Farmaco (Società chimica italiana : 1989) 2000-05, Vol.55 (5), p.354-361 |
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| container_title | Farmaco (Società chimica italiana : 1989) |
| container_volume | 55 |
| creator | Ghorab, M.M El-Sharief, A.M.Sh Ammar, Y.A Mohamed, Sh.I |
| description | Some novel 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazino-3-yl)ethane (
4–
7); 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazol-3-yl)ethane (
16a,
b) and 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazepino-3-yl)ethane (
17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane (
3) with different reagents. Identification of the new compounds was established by elemental analyses, IR,
1H NMR and mass spectral data. Compounds
12,
13,
16b and
17 were promising antifungal activity. The biologically active compounds
13,
16b and
17 were radioresistant retaining their structures unchanged up to 40 k Gy. Radiosterilization of these compounds in the dry state may prove to be applicable. |
| doi_str_mv | 10.1016/S0014-827X(00)00051-3 |
| format | Article |
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b][1,3,4]thiadiazino-3-yl)ethane (
4–
7); 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazol-3-yl)ethane (
16a,
b) and 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazepino-3-yl)ethane (
17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane (
3) with different reagents. Identification of the new compounds was established by elemental analyses, IR,
1H NMR and mass spectral data. Compounds
12,
13,
16b and
17 were promising antifungal activity. The biologically active compounds
13,
16b and
17 were radioresistant retaining their structures unchanged up to 40 k Gy. Radiosterilization of these compounds in the dry state may prove to be applicable.</description><identifier>ISSN: 0014-827X</identifier><identifier>EISSN: 1879-0569</identifier><identifier>DOI: 10.1016/S0014-827X(00)00051-3</identifier><identifier>PMID: 10983280</identifier><language>eng</language><publisher>Lausanne: Elsevier SAS</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal activity ; Antifungal agents ; Antifungal Agents - chemical synthesis ; Antifungal Agents - radiation effects ; Biological and medical sciences ; Drug Stability ; Gamma Rays ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Spectrum Analysis ; Sterilization ; Triazoles ; Triazoles - chemical synthesis ; Triazoles - radiation effects ; Triazolothiadiazine ; Triazolothiadiazole ; γ-Rays</subject><ispartof>Farmaco (Società chimica italiana : 1989), 2000-05, Vol.55 (5), p.354-361</ispartof><rights>2000 Elsevier Science S.A.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-67006c248f9bcf0235a363814ab5739b343370d4ded8bb351fca918e97224d343</citedby><cites>FETCH-LOGICAL-c390t-67006c248f9bcf0235a363814ab5739b343370d4ded8bb351fca918e97224d343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1453070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10983280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorab, M.M</creatorcontrib><creatorcontrib>El-Sharief, A.M.Sh</creatorcontrib><creatorcontrib>Ammar, Y.A</creatorcontrib><creatorcontrib>Mohamed, Sh.I</creatorcontrib><title>Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane</title><title>Farmaco (Società chimica italiana : 1989)</title><addtitle>Farmaco</addtitle><description>Some novel 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazino-3-yl)ethane (
4–
7); 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazol-3-yl)ethane (
16a,
b) and 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazepino-3-yl)ethane (
17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane (
3) with different reagents. Identification of the new compounds was established by elemental analyses, IR,
1H NMR and mass spectral data. Compounds
12,
13,
16b and
17 were promising antifungal activity. The biologically active compounds
13,
16b and
17 were radioresistant retaining their structures unchanged up to 40 k Gy. Radiosterilization of these compounds in the dry state may prove to be applicable.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - radiation effects</subject><subject>Biological and medical sciences</subject><subject>Drug Stability</subject><subject>Gamma Rays</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrum Analysis</subject><subject>Sterilization</subject><subject>Triazoles</subject><subject>Triazoles - chemical synthesis</subject><subject>Triazoles - radiation effects</subject><subject>Triazolothiadiazine</subject><subject>Triazolothiadiazole</subject><subject>γ-Rays</subject><issn>0014-827X</issn><issn>1879-0569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFTEQhoMozpnRR1CyEJkBo5VOp9O9GmQYLzDgYhTchdzaiaQ7xyR9oH0H39mcOQd156qoqq8u_D9Czyi8pkC7N7cAtCV9I76eA1wAAKeEPUAb2ouBAO-Gh2jzBzlBpzl_r6kQnXiMTigMPWt62KBft-tc7lz2GavZ4qSsV8XHGeeitA--rDiOeI47F7D2McRv3qgQVqxM8TuH8xLGJWETp21cZpuxdanWLR5TnDB91RDt83lL1OTnSDiZXDJqWyLJpCSvfsZAGFnDhSt3anZP0KNRheyeHuMZ-vLu-vPVB3Lz6f3Hq7c3xLABCukEQGeath8HbUZoGFesYz1tleaCDZq1jAmwrXW215pxOho10N4NomlaW7tn6OVh7zbFH4vLRU4-GxdC_SEuWVaOc9F0FeQH0KSYc3Kj3CY_qbRKCnLvg7z3Qe5FlgDy3gfJ6tzz44FFT87-M3UQvgIvjoDKVdAxqdn4_JdrOQOxxy4PmKtq7LxLMhvvZuOsT84UaaP_zye_AVPrpZ8</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Ghorab, M.M</creator><creator>El-Sharief, A.M.Sh</creator><creator>Ammar, Y.A</creator><creator>Mohamed, Sh.I</creator><general>Elsevier SAS</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane</title><author>Ghorab, M.M ; El-Sharief, A.M.Sh ; Ammar, Y.A ; Mohamed, Sh.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-67006c248f9bcf0235a363814ab5739b343370d4ded8bb351fca918e97224d343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - radiation effects</topic><topic>Biological and medical sciences</topic><topic>Drug Stability</topic><topic>Gamma Rays</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrum Analysis</topic><topic>Sterilization</topic><topic>Triazoles</topic><topic>Triazoles - chemical synthesis</topic><topic>Triazoles - radiation effects</topic><topic>Triazolothiadiazine</topic><topic>Triazolothiadiazole</topic><topic>γ-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghorab, M.M</creatorcontrib><creatorcontrib>El-Sharief, A.M.Sh</creatorcontrib><creatorcontrib>Ammar, Y.A</creatorcontrib><creatorcontrib>Mohamed, Sh.I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Farmaco (Società chimica italiana : 1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghorab, M.M</au><au>El-Sharief, A.M.Sh</au><au>Ammar, Y.A</au><au>Mohamed, Sh.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane</atitle><jtitle>Farmaco (Società chimica italiana : 1989)</jtitle><addtitle>Farmaco</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>55</volume><issue>5</issue><spage>354</spage><epage>361</epage><pages>354-361</pages><issn>0014-827X</issn><eissn>1879-0569</eissn><abstract>Some novel 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazino-3-yl)ethane (
4–
7); 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazol-3-yl)ethane (
16a,
b) and 1,2-bis(s-triazolo[3,4
b][1,3,4]thiadiazepino-3-yl)ethane (
17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane (
3) with different reagents. Identification of the new compounds was established by elemental analyses, IR,
1H NMR and mass spectral data. Compounds
12,
13,
16b and
17 were promising antifungal activity. The biologically active compounds
13,
16b and
17 were radioresistant retaining their structures unchanged up to 40 k Gy. Radiosterilization of these compounds in the dry state may prove to be applicable.</abstract><cop>Lausanne</cop><pub>Elsevier SAS</pub><pmid>10983280</pmid><doi>10.1016/S0014-827X(00)00051-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-827X |
| ispartof | Farmaco (Società chimica italiana : 1989), 2000-05, Vol.55 (5), p.354-361 |
| issn | 0014-827X 1879-0569 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - radiation effects Biological and medical sciences Drug Stability Gamma Rays Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Spectrum Analysis Sterilization Triazoles Triazoles - chemical synthesis Triazoles - radiation effects Triazolothiadiazine Triazolothiadiazole γ-Rays |
| title | Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane |
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