IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki Disease
The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues ar...
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| Veröffentlicht in: | The Journal of infectious diseases 2000-10, Vol.182 (4), p.1183-1191 |
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| creator | Rowley, Anne H. Shulman, Stanford T. Mask, Carrie A. Finn, Laura S. Terai, Masaru Baker, Susan C. Galliani, Carlos A. Takahashi, Kei Naoe, Shiro Kalelkar, Mitra B. Crawford, Susan E. |
| description | The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P < .01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney. |
| doi_str_mv | 10.1086/315832 |
| format | Article |
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As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P < .01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315832</identifier><identifier>PMID: 10979916</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acute Disease ; Antibodies ; Biological and medical sciences ; Cause of Death ; Child ; Child, Preschool ; Coronary vessels ; Coronary Vessels - immunology ; Coronary Vessels - pathology ; Diseases ; Ethnic Groups ; Female ; Humans ; Immunoglobulin A - analysis ; Infant ; Japan ; Kidney - immunology ; Kidney - pathology ; Kidneys ; Lungs ; Major Articles ; Male ; Medical sciences ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - immunology ; Mucocutaneous Lymph Node Syndrome - pathology ; Pancreas ; Pancreas - immunology ; Pancreas - pathology ; Pathology ; Plasma cells ; Plasma Cells - immunology ; Plasma Cells - pathology ; Respiratory System - immunology ; Respiratory System - pathology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Trachea ; United States</subject><ispartof>The Journal of infectious diseases, 2000-10, Vol.182 (4), p.1183-1191</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2001 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-6a29d3c42b2d39a0049aa2e2a1ff88b6a01173d42fa92b20153ea735175351a63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30110095$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30110095$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=970429$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10979916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rowley, Anne H.</creatorcontrib><creatorcontrib>Shulman, Stanford T.</creatorcontrib><creatorcontrib>Mask, Carrie A.</creatorcontrib><creatorcontrib>Finn, Laura S.</creatorcontrib><creatorcontrib>Terai, Masaru</creatorcontrib><creatorcontrib>Baker, Susan C.</creatorcontrib><creatorcontrib>Galliani, Carlos A.</creatorcontrib><creatorcontrib>Takahashi, Kei</creatorcontrib><creatorcontrib>Naoe, Shiro</creatorcontrib><creatorcontrib>Kalelkar, Mitra B.</creatorcontrib><creatorcontrib>Crawford, Susan E.</creatorcontrib><title>IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki Disease</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P < .01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney.</description><subject>Acute Disease</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Cause of Death</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - immunology</subject><subject>Coronary Vessels - pathology</subject><subject>Diseases</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Infant</subject><subject>Japan</subject><subject>Kidney - immunology</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Lungs</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - immunology</subject><subject>Mucocutaneous Lymph Node Syndrome - pathology</subject><subject>Pancreas</subject><subject>Pancreas - immunology</subject><subject>Pancreas - pathology</subject><subject>Pathology</subject><subject>Plasma cells</subject><subject>Plasma Cells - immunology</subject><subject>Plasma Cells - pathology</subject><subject>Respiratory System - immunology</subject><subject>Respiratory System - pathology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Trachea</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowley, Anne H.</creatorcontrib><creatorcontrib>Shulman, Stanford T.</creatorcontrib><creatorcontrib>Mask, Carrie A.</creatorcontrib><creatorcontrib>Finn, Laura S.</creatorcontrib><creatorcontrib>Terai, Masaru</creatorcontrib><creatorcontrib>Baker, Susan C.</creatorcontrib><creatorcontrib>Galliani, Carlos A.</creatorcontrib><creatorcontrib>Takahashi, Kei</creatorcontrib><creatorcontrib>Naoe, Shiro</creatorcontrib><creatorcontrib>Kalelkar, Mitra B.</creatorcontrib><creatorcontrib>Crawford, Susan E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowley, Anne H.</au><au>Shulman, Stanford T.</au><au>Mask, Carrie A.</au><au>Finn, Laura S.</au><au>Terai, Masaru</au><au>Baker, Susan C.</au><au>Galliani, Carlos A.</au><au>Takahashi, Kei</au><au>Naoe, Shiro</au><au>Kalelkar, Mitra B.</au><au>Crawford, Susan E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki Disease</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>182</volume><issue>4</issue><spage>1183</spage><epage>1191</epage><pages>1183-1191</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P < .01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10979916</pmid><doi>10.1086/315832</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Acute Disease Antibodies Biological and medical sciences Cause of Death Child Child, Preschool Coronary vessels Coronary Vessels - immunology Coronary Vessels - pathology Diseases Ethnic Groups Female Humans Immunoglobulin A - analysis Infant Japan Kidney - immunology Kidney - pathology Kidneys Lungs Major Articles Male Medical sciences Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - immunology Mucocutaneous Lymph Node Syndrome - pathology Pancreas Pancreas - immunology Pancreas - pathology Pathology Plasma cells Plasma Cells - immunology Plasma Cells - pathology Respiratory System - immunology Respiratory System - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Trachea United States |
| title | IgA Plasma Cell Infiltration of Proximal Respiratory Tract, Pancreas, Kidney, and Coronary Artery in Acute Kawasaki Disease |
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