Conservation of the Respiratory Syncytial Virus SH Gene
Respiratory syncytial virus (RSV) encodes a short (64 or 65 amino acids) hydrophobic (SH) protein whose function in viral replication and pathogenesis is not understood. We carried out molecular epidemiological studies of the SH gene during the 1998–1999 seasonal epidemic in New Haven, Connecticut....
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| Veröffentlicht in: | The Journal of infectious diseases 2000-10, Vol.182 (4), p.1228-1233 |
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| creator | Chen, Martin D. Vazquez, Marietta Buonocore, Linda Kahn, Jeffrey S. |
| description | Respiratory syncytial virus (RSV) encodes a short (64 or 65 amino acids) hydrophobic (SH) protein whose function in viral replication and pathogenesis is not understood. We carried out molecular epidemiological studies of the SH gene during the 1998–1999 seasonal epidemic in New Haven, Connecticut. Strains circulating during the epidemic were related to viruses identified worldwide. The SH gene transcriptional control signals were conserved in 70 (98.6%) of 71 isolates that we sequenced. The deduced amino acid sequence of the SH protein was nearly identical to subgroup A and subgroup B reference strains that were isolated in 1961 and 1962, respectively. Twenty-six (96.3%) of 27 subgroup A strains contained 0 or 1 amino acid substitution, compared with that of the reference A2 strain. Most subgroup B isolates (38 [86.4%] of 44 strains) contained 0, 1, or 2 amino acid substitutions, compared with that of the reference B18537 strain. |
| doi_str_mv | 10.1086/315829 |
| format | Article |
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We carried out molecular epidemiological studies of the SH gene during the 1998–1999 seasonal epidemic in New Haven, Connecticut. Strains circulating during the epidemic were related to viruses identified worldwide. The SH gene transcriptional control signals were conserved in 70 (98.6%) of 71 isolates that we sequenced. The deduced amino acid sequence of the SH protein was nearly identical to subgroup A and subgroup B reference strains that were isolated in 1961 and 1962, respectively. Twenty-six (96.3%) of 27 subgroup A strains contained 0 or 1 amino acid substitution, compared with that of the reference A2 strain. Most subgroup B isolates (38 [86.4%] of 44 strains) contained 0, 1, or 2 amino acid substitutions, compared with that of the reference B18537 strain.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315829</identifier><identifier>PMID: 10979923</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amino Acid Sequence ; Amino acid substitution ; Amino acids ; ASH gene ; ASH protein ; Base Sequence ; Biological and medical sciences ; Concise Communication ; Connecticut - epidemiology ; DNA Primers ; Epidemics ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Viral ; Genetic heterogeneity ; Glycoproteins ; Human respiratory syncytial virus ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Molecular Sequence Data ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - virology ; Respiratory syncytial viruses ; Respiratory Syncytial Viruses - genetics ; Respiratory Syncytial Viruses - isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Transcriptional regulatory elements ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Viral Proteins - chemistry ; Viral Proteins - genetics ; Viral Structural Proteins - genetics ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2000-10, Vol.182 (4), p.1228-1233</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2001 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1302aab1ba276f1781e2c0b1ac715714656d7540a1a497ea086d780587e0a4f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30110102$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30110102$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=971978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10979923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Martin D.</creatorcontrib><creatorcontrib>Vazquez, Marietta</creatorcontrib><creatorcontrib>Buonocore, Linda</creatorcontrib><creatorcontrib>Kahn, Jeffrey S.</creatorcontrib><title>Conservation of the Respiratory Syncytial Virus SH Gene</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Respiratory syncytial virus (RSV) encodes a short (64 or 65 amino acids) hydrophobic (SH) protein whose function in viral replication and pathogenesis is not understood. We carried out molecular epidemiological studies of the SH gene during the 1998–1999 seasonal epidemic in New Haven, Connecticut. Strains circulating during the epidemic were related to viruses identified worldwide. The SH gene transcriptional control signals were conserved in 70 (98.6%) of 71 isolates that we sequenced. The deduced amino acid sequence of the SH protein was nearly identical to subgroup A and subgroup B reference strains that were isolated in 1961 and 1962, respectively. Twenty-six (96.3%) of 27 subgroup A strains contained 0 or 1 amino acid substitution, compared with that of the reference A2 strain. Most subgroup B isolates (38 [86.4%] of 44 strains) contained 0, 1, or 2 amino acid substitutions, compared with that of the reference B18537 strain.</description><subject>Amino Acid Sequence</subject><subject>Amino acid substitution</subject><subject>Amino acids</subject><subject>ASH gene</subject><subject>ASH protein</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Concise Communication</subject><subject>Connecticut - epidemiology</subject><subject>DNA Primers</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes, Viral</subject><subject>Genetic heterogeneity</subject><subject>Glycoproteins</subject><subject>Human respiratory syncytial virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory syncytial viruses</subject><subject>Respiratory Syncytial Viruses - genetics</subject><subject>Respiratory Syncytial Viruses - isolation & purification</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transcriptional regulatory elements</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Viral Proteins - chemistry</subject><subject>Viral Proteins - genetics</subject><subject>Viral Structural Proteins - genetics</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv00AQhVcIRNMC_4DKolJvhplde8d7bC3aVIqERAAhLquJsxZOHTvdtRH592zlKEVcOM3hffr05gnxBuE9QqE_KMwLaZ6JGeaKUq1RPRczAClTLIw5EachbAAgU5peihMEQ8ZINRNU9l1w_hcPTd8lfZ0MP13y2YVd43no_T5Z7rtqPzTcJt8aP4ZkOU9uXedeiRc1t8G9Ptwz8fXm45dyni4-3d6VV4u0yiQOKSqQzCtcsSRdIxXoZAUr5IowJ8x0rteUZ8DImSHH8ZU1FZAX5ICzGtSZuJy8O98_jC4MdtuEyrUtd64fgyUpc6Wh-C-IZBCjOILv_gE3_ei7-ISVUhkwRtGTrfJ9CN7VduebLfu9RbCPg9tp8AieH2zjauvWf2HTwhG4OAAcKm5rz13VhCNnCA09lno7UZsQVz-mCmJnBBnzdMqbMLjfx5z9vdWkKLfz7z_scl7SIisze63-AHu0m64</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Chen, Martin D.</creator><creator>Vazquez, Marietta</creator><creator>Buonocore, Linda</creator><creator>Kahn, Jeffrey S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Conservation of the Respiratory Syncytial Virus SH Gene</title><author>Chen, Martin D. ; Vazquez, Marietta ; Buonocore, Linda ; Kahn, Jeffrey S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1302aab1ba276f1781e2c0b1ac715714656d7540a1a497ea086d780587e0a4f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acid substitution</topic><topic>Amino acids</topic><topic>ASH gene</topic><topic>ASH protein</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Concise Communication</topic><topic>Connecticut - epidemiology</topic><topic>DNA Primers</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genes, Viral</topic><topic>Genetic heterogeneity</topic><topic>Glycoproteins</topic><topic>Human respiratory syncytial virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory syncytial viruses</topic><topic>Respiratory Syncytial Viruses - genetics</topic><topic>Respiratory Syncytial Viruses - isolation & purification</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcriptional regulatory elements</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><topic>Viral Proteins - chemistry</topic><topic>Viral Proteins - genetics</topic><topic>Viral Structural Proteins - genetics</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Martin D.</creatorcontrib><creatorcontrib>Vazquez, Marietta</creatorcontrib><creatorcontrib>Buonocore, Linda</creatorcontrib><creatorcontrib>Kahn, Jeffrey S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Martin D.</au><au>Vazquez, Marietta</au><au>Buonocore, Linda</au><au>Kahn, Jeffrey S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conservation of the Respiratory Syncytial Virus SH Gene</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>182</volume><issue>4</issue><spage>1228</spage><epage>1233</epage><pages>1228-1233</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Respiratory syncytial virus (RSV) encodes a short (64 or 65 amino acids) hydrophobic (SH) protein whose function in viral replication and pathogenesis is not understood. We carried out molecular epidemiological studies of the SH gene during the 1998–1999 seasonal epidemic in New Haven, Connecticut. Strains circulating during the epidemic were related to viruses identified worldwide. The SH gene transcriptional control signals were conserved in 70 (98.6%) of 71 isolates that we sequenced. The deduced amino acid sequence of the SH protein was nearly identical to subgroup A and subgroup B reference strains that were isolated in 1961 and 1962, respectively. Twenty-six (96.3%) of 27 subgroup A strains contained 0 or 1 amino acid substitution, compared with that of the reference A2 strain. Most subgroup B isolates (38 [86.4%] of 44 strains) contained 0, 1, or 2 amino acid substitutions, compared with that of the reference B18537 strain.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10979923</pmid><doi>10.1086/315829</doi><tpages>6</tpages></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Amino Acid Sequence Amino acid substitution Amino acids ASH gene ASH protein Base Sequence Biological and medical sciences Concise Communication Connecticut - epidemiology DNA Primers Epidemics Epidemiology Fundamental and applied biological sciences. Psychology Genes Genes, Viral Genetic heterogeneity Glycoproteins Human respiratory syncytial virus Human viral diseases Humans Infectious diseases Medical sciences Microbiology Molecular Sequence Data Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - virology Respiratory syncytial viruses Respiratory Syncytial Viruses - genetics Respiratory Syncytial Viruses - isolation & purification Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Transcriptional regulatory elements Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Proteins - chemistry Viral Proteins - genetics Viral Structural Proteins - genetics Virology Viruses |
| title | Conservation of the Respiratory Syncytial Virus SH Gene |
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