Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease
Objective: Only few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed. Patients and methods: Thirty-...
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| Veröffentlicht in: | Auris, nasus, larynx nasus, larynx, 2001-11, Vol.28 (4), p.339-344 |
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| container_title | Auris, nasus, larynx |
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| creator | Dünne, Anja-A. Külkens, Christoph Ramaswamy, Annette Folz, Benedikt J. Brandt, Desiree Lippert, Burkard M. Behr, Th Moll, Roland Werner, Jochen A. |
| description | Objective: Only few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed.
Patients and methods: Thirty-eight previously untreated patients with clinically N0-neck were staged by intraoperative SN biopsy. After intraoperative identification of the hottest node (SN
1) and further less tracer accumulating lymph nodes (SN
2, SN
3), patients were treated by different types of neck dissection (ND), adjusted to the location and extent of the primary tumour. Postoperatively the histologic results of the SN
1–3 and the entire ND specimen were compared.
Results: The stage of cervical metastatic disease was demonstrated by a disease-free SN
1 in 32 patients. In five patients an isolated metastasis could be proven in the intraoperatively identified SN
1, while in the remaining patient an isolated metastasis was found in the SN
2.
Conclusion: Intraoperative SN biopsy seems to be valuable for the detection of occult lymph node metastases in HNSCC. This method might help to limit the extent of ipsilateral ND, if used as an intraoperative staging procedure to investigate the first draining tracer accumulating lymph nodes (SN
1–3). |
| doi_str_mv | 10.1016/S0385-8146(01)00107-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72252511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0385814601001079</els_id><sourcerecordid>72252511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-6d5a24428156c0913255f2073fec405c9804cd43d4c057d2947f01aa263529f93</originalsourceid><addsrcrecordid>eNqFkEtv1DAURi0EokPhJ1B5hWARuH7F8apCFS-pEgseW8vYNx23iT2NnaL59ySdUbtkdRc-9_uuDyGvGbxnwNoPP0B0qumYbN8CewfAQDfmCdmwTpuGSd0-JZsH5IS8KOUaAIQW5jk5Yaw1UmizIfNvN8xIc08LphoTDnTYj7ttTjmgr3nc05joFl2gLgWa0N9Q75LHie5cjctOoX9j3ea5UryLAZenNe0QcoUpejpidaUutKchFnQFX5JnvRsKvjrOU_Lr86efF1-by-9fvl18vGz8cnlt2qAcl5J3TLUeDBNcqZ6DFj16CcqbDqQPUgTpQenAjdQ9MOd4KxQ3vRGn5M0hdzfl2xlLtWMsHofBJcxzsZpzxRVjC6gOoJ9yKRP2djfF0U17y8Cuvu29b7vKtMDsvW-7FpwdC-Y_I4bHraPgBTg_ALh88y7iZIuPq6QQp8WvDTn-p-IfHWSQpw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72252511</pqid></control><display><type>article</type><title>Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Dünne, Anja-A. ; Külkens, Christoph ; Ramaswamy, Annette ; Folz, Benedikt J. ; Brandt, Desiree ; Lippert, Burkard M. ; Behr, Th ; Moll, Roland ; Werner, Jochen A.</creator><creatorcontrib>Dünne, Anja-A. ; Külkens, Christoph ; Ramaswamy, Annette ; Folz, Benedikt J. ; Brandt, Desiree ; Lippert, Burkard M. ; Behr, Th ; Moll, Roland ; Werner, Jochen A.</creatorcontrib><description>Objective: Only few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed.
Patients and methods: Thirty-eight previously untreated patients with clinically N0-neck were staged by intraoperative SN biopsy. After intraoperative identification of the hottest node (SN
1) and further less tracer accumulating lymph nodes (SN
2, SN
3), patients were treated by different types of neck dissection (ND), adjusted to the location and extent of the primary tumour. Postoperatively the histologic results of the SN
1–3 and the entire ND specimen were compared.
Results: The stage of cervical metastatic disease was demonstrated by a disease-free SN
1 in 32 patients. In five patients an isolated metastasis could be proven in the intraoperatively identified SN
1, while in the remaining patient an isolated metastasis was found in the SN
2.
Conclusion: Intraoperative SN biopsy seems to be valuable for the detection of occult lymph node metastases in HNSCC. This method might help to limit the extent of ipsilateral ND, if used as an intraoperative staging procedure to investigate the first draining tracer accumulating lymph nodes (SN
1–3).</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/S0385-8146(01)00107-9</identifier><identifier>PMID: 11694379</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Female ; Head and neck squamous cell carcinoma ; Humans ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Lymphatic spread ; Male ; Middle Aged ; Neoplasm Staging ; Occult metastases ; Otorhinolaryngologic Neoplasms - pathology ; Otorhinolaryngologic Neoplasms - surgery ; Prognosis ; Sentinel lymph node ; Sentinel Lymph Node Biopsy ; Sentinel node biopsy</subject><ispartof>Auris, nasus, larynx, 2001-11, Vol.28 (4), p.339-344</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-6d5a24428156c0913255f2073fec405c9804cd43d4c057d2947f01aa263529f93</citedby><cites>FETCH-LOGICAL-c385t-6d5a24428156c0913255f2073fec405c9804cd43d4c057d2947f01aa263529f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0385814601001079$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11694379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dünne, Anja-A.</creatorcontrib><creatorcontrib>Külkens, Christoph</creatorcontrib><creatorcontrib>Ramaswamy, Annette</creatorcontrib><creatorcontrib>Folz, Benedikt J.</creatorcontrib><creatorcontrib>Brandt, Desiree</creatorcontrib><creatorcontrib>Lippert, Burkard M.</creatorcontrib><creatorcontrib>Behr, Th</creatorcontrib><creatorcontrib>Moll, Roland</creatorcontrib><creatorcontrib>Werner, Jochen A.</creatorcontrib><title>Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>Objective: Only few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed.
Patients and methods: Thirty-eight previously untreated patients with clinically N0-neck were staged by intraoperative SN biopsy. After intraoperative identification of the hottest node (SN
1) and further less tracer accumulating lymph nodes (SN
2, SN
3), patients were treated by different types of neck dissection (ND), adjusted to the location and extent of the primary tumour. Postoperatively the histologic results of the SN
1–3 and the entire ND specimen were compared.
Results: The stage of cervical metastatic disease was demonstrated by a disease-free SN
1 in 32 patients. In five patients an isolated metastasis could be proven in the intraoperatively identified SN
1, while in the remaining patient an isolated metastasis was found in the SN
2.
Conclusion: Intraoperative SN biopsy seems to be valuable for the detection of occult lymph node metastases in HNSCC. This method might help to limit the extent of ipsilateral ND, if used as an intraoperative staging procedure to investigate the first draining tracer accumulating lymph nodes (SN
1–3).</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Head and neck squamous cell carcinoma</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic spread</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Occult metastases</subject><subject>Otorhinolaryngologic Neoplasms - pathology</subject><subject>Otorhinolaryngologic Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Sentinel lymph node</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Sentinel node biopsy</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAURi0EokPhJ1B5hWARuH7F8apCFS-pEgseW8vYNx23iT2NnaL59ySdUbtkdRc-9_uuDyGvGbxnwNoPP0B0qumYbN8CewfAQDfmCdmwTpuGSd0-JZsH5IS8KOUaAIQW5jk5Yaw1UmizIfNvN8xIc08LphoTDnTYj7ttTjmgr3nc05joFl2gLgWa0N9Q75LHie5cjctOoX9j3ea5UryLAZenNe0QcoUpejpidaUutKchFnQFX5JnvRsKvjrOU_Lr86efF1-by-9fvl18vGz8cnlt2qAcl5J3TLUeDBNcqZ6DFj16CcqbDqQPUgTpQenAjdQ9MOd4KxQ3vRGn5M0hdzfl2xlLtWMsHofBJcxzsZpzxRVjC6gOoJ9yKRP2djfF0U17y8Cuvu29b7vKtMDsvW-7FpwdC-Y_I4bHraPgBTg_ALh88y7iZIuPq6QQp8WvDTn-p-IfHWSQpw</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Dünne, Anja-A.</creator><creator>Külkens, Christoph</creator><creator>Ramaswamy, Annette</creator><creator>Folz, Benedikt J.</creator><creator>Brandt, Desiree</creator><creator>Lippert, Burkard M.</creator><creator>Behr, Th</creator><creator>Moll, Roland</creator><creator>Werner, Jochen A.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20011101</creationdate><title>Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease</title><author>Dünne, Anja-A. ; Külkens, Christoph ; Ramaswamy, Annette ; Folz, Benedikt J. ; Brandt, Desiree ; Lippert, Burkard M. ; Behr, Th ; Moll, Roland ; Werner, Jochen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-6d5a24428156c0913255f2073fec405c9804cd43d4c057d2947f01aa263529f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Head and neck squamous cell carcinoma</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic spread</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Occult metastases</topic><topic>Otorhinolaryngologic Neoplasms - pathology</topic><topic>Otorhinolaryngologic Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Sentinel lymph node</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Sentinel node biopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dünne, Anja-A.</creatorcontrib><creatorcontrib>Külkens, Christoph</creatorcontrib><creatorcontrib>Ramaswamy, Annette</creatorcontrib><creatorcontrib>Folz, Benedikt J.</creatorcontrib><creatorcontrib>Brandt, Desiree</creatorcontrib><creatorcontrib>Lippert, Burkard M.</creatorcontrib><creatorcontrib>Behr, Th</creatorcontrib><creatorcontrib>Moll, Roland</creatorcontrib><creatorcontrib>Werner, Jochen A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dünne, Anja-A.</au><au>Külkens, Christoph</au><au>Ramaswamy, Annette</au><au>Folz, Benedikt J.</au><au>Brandt, Desiree</au><au>Lippert, Burkard M.</au><au>Behr, Th</au><au>Moll, Roland</au><au>Werner, Jochen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>28</volume><issue>4</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>Objective: Only few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed.
Patients and methods: Thirty-eight previously untreated patients with clinically N0-neck were staged by intraoperative SN biopsy. After intraoperative identification of the hottest node (SN
1) and further less tracer accumulating lymph nodes (SN
2, SN
3), patients were treated by different types of neck dissection (ND), adjusted to the location and extent of the primary tumour. Postoperatively the histologic results of the SN
1–3 and the entire ND specimen were compared.
Results: The stage of cervical metastatic disease was demonstrated by a disease-free SN
1 in 32 patients. In five patients an isolated metastasis could be proven in the intraoperatively identified SN
1, while in the remaining patient an isolated metastasis was found in the SN
2.
Conclusion: Intraoperative SN biopsy seems to be valuable for the detection of occult lymph node metastases in HNSCC. This method might help to limit the extent of ipsilateral ND, if used as an intraoperative staging procedure to investigate the first draining tracer accumulating lymph nodes (SN
1–3).</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>11694379</pmid><doi>10.1016/S0385-8146(01)00107-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Auris, nasus, larynx, 2001-11, Vol.28 (4), p.339-344 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Female Head and neck squamous cell carcinoma Humans Lymph Node Excision Lymph Nodes - pathology Lymphatic Metastasis Lymphatic spread Male Middle Aged Neoplasm Staging Occult metastases Otorhinolaryngologic Neoplasms - pathology Otorhinolaryngologic Neoplasms - surgery Prognosis Sentinel lymph node Sentinel Lymph Node Biopsy Sentinel node biopsy |
| title | Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease |
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