Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

β-Amyloid peptide (Aβ) is generated by two cleavages of amyloid precursor protein (APP). The initial cleavage by BACE is followed by γ-secretase cleavage of the C-terminal APP fragment. Presenilin-1 (PS-1) is intimately related to γ-secretase. Once formed, Aβ is mainly broken down by neprilysin. To...

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Veröffentlicht in:	Brain research 2001-11, Vol.919 (1), p.115-121
Hauptverfasser:	Yasojima, K, McGeer, E.G, McGeer, P.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - enzymology Alzheimer Disease - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Analysis of Variance BACE Biological and medical sciences Brain - metabolism CD10 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enkephalinase Female Heart Humans Kidney Kidney - metabolism Liver Liver - metabolism Male Medical sciences mRNA Myocardium - metabolism Neprilysin - metabolism Neurology Peptide Fragments - genetics Peptide Fragments - metabolism PS-1 RNA, Messenger - metabolism Spleen Spleen - metabolism
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