The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins

Neuropeptides like galanin produced and released by small cell lung cancer (SCLC) cells are considered principal mitogens in these tumors. We identified the galanin receptor type 2 (GALR2) as the only galanin receptor expressed in H69 and H510 cells. Photoaffinity labeling of G proteins in H69 cell...

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Veröffentlicht in:	Oncogene 2000-08, Vol.19 (37), p.4199-4209
Hauptverfasser:	Wittau, N, Grosse, R, Kalkbrenner, F, Gohla, A, Schultz, G, Gudermann, T
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3T3 Cells - drug effects Actin Cytoskeleton - metabolism Actins - metabolism Animals Calcium Signaling - drug effects Calcium Signaling - physiology Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology Cell Adhesion COS Cells - drug effects Cyclic AMP - physiology Enzyme Inhibitors - pharmacology Galanin - metabolism Galanin - pharmacology GTP-Binding Protein alpha Subunits, G12-G13 GTP-Binding Protein alpha Subunits, Gi-Go - physiology GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Proteins - physiology Heterotrimeric GTP-Binding Proteins - physiology Humans Indoles - pharmacology Inositol Phosphates - metabolism Intracellular Signaling Peptides and Proteins Isoproterenol - pharmacology Lung Neoplasms - metabolism Lung Neoplasms - pathology Maleimides - pharmacology Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Pertussis Toxin Phosphatidylinositol Diacylglycerol-Lyase Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein-Serine-Threonine Kinases - physiology Receptor, Galanin, Type 2 Receptors, Galanin Receptors, Neuropeptide - drug effects Receptors, Neuropeptide - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology rho-Associated Kinases rhoA GTP-Binding Protein - physiology Transfection Tumor Cells, Cultured - metabolism Type C Phospholipases - metabolism Virulence Factors, Bordetella - pharmacology
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