Enhanced pulmonary absorption following aerosol administration of mucoadhesive powder microspheres

Mucoadhesive, hydroxypropylcellulose (HPC) microspheres were prepared for powder inhalation and their feasibility for enhancing pulmonary drug absorption was investigated. Respirable-sized microspheres, incorporating crystalline or amorphous fluorescein (used as a model drug), were prepared by spray...

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Veröffentlicht in:	Journal of controlled release 2001-11, Vol.77 (1), p.117-129
Hauptverfasser:	Sakagami, Masahiro, Sakon, Kiyoyuki, Kinoshita, Wataru, Makino, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Aerosol drug delivery Aerosols Animals Biological and medical sciences Cellulose - administration & dosage Cellulose - analogs & derivatives Crystallinity Fluorescein - metabolism General pharmacology Guinea Pigs Lung - metabolism Medical sciences Microspheres Mucoadhesion Mucociliary clearance Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders
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