Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption

In order to continue the previous morphological studies of eyes from mice with adenomatous polyposis coli (APC) gene mutation at codon 1638, we determined the ultrastructural and electrophysiologic characteristics of these eyes. Thirty-eight eyes from 20 mice heterozygous for APC gene mutation and 2...

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Veröffentlicht in:	Molecular vision 2000-09, Vol.6, p.169-177
Hauptverfasser:	Marcus, D M, Rustgi, A K, Defoe, D, Kucherlapati, R, Edelmann, W, Hamasaki, D, Liou, G I, Smith, S B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - pathology Adenomatous Polyposis Coli - physiopathology Animals Atrophy Disease Models, Animal Electroretinography Genes, APC Hyperplasia Melanosomes - ultrastructure Mice Mice, Inbred C57BL Mice, Mutant Strains Pigment Epithelium of Eye - abnormalities Pigment Epithelium of Eye - ultrastructure Retina - abnormalities Retina - physiopathology Retina - ultrastructure Retinal Diseases - genetics Retinal Diseases - pathology Retinal Diseases - physiopathology
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