Structural Studies of LNA:RNA Duplexes by NMR: Conformations and Implications for RNase H Activity

We have used NMR and CD spectroscopy to study the conformations of modified oligonucleotides (locked nucleic acid, LNA) containing a conformationally restricted nucleotide (TL) with a 2′‐O,4′‐C‐methylene bridge. We have investigated two LNA:RNA duplexes, d(CTGATLATGC):r(GCAUAUCAG) and d(CTLGATLATLGC...

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Veröffentlicht in:	Chemistry : a European journal 2000-08, Vol.6 (15), p.2687-2695
Hauptverfasser:	Bondensgaard, Kent, Petersen, Michael, Singh, Sanjay K., Rajwanshi, Vivek K., Kumar, Ravindra, Wengel, Jesper, Jacobsen, Jens Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense agents Base Sequence enzyme catalysis locked nucleic acids Models, Molecular Nuclear Magnetic Resonance, Biomolecular - methods Nucleic Acid Conformation nucleic acids Oligodeoxyribonucleotides - chemistry Oligoribonucleotides - chemistry Ribonuclease H - metabolism RNA RNA - chemistry RNA - metabolism
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