Nonosseous Uptake on Bone Scan in Adenocarcinoma of Unknown Primary Origin
Two patients without histories of cancer underwent Tc-99m MDP bone scans as part of evaluations of pain and abnormal laboratory and radiologic findings. Both scans showed abnormal soft tissue uptake in tumor deposits and in visceral organs associated with hypercalcemia and metastatic calcification....
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| Veröffentlicht in: | Clinical nuclear medicine 2000-09, Vol.25 (9), p.751-752 |
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| creator | CHEN, XIAOMING JACOBSON, ARNOLD F |
| description | Two patients without histories of cancer underwent Tc-99m MDP bone scans as part of evaluations of pain and abnormal laboratory and radiologic findings. Both scans showed abnormal soft tissue uptake in tumor deposits and in visceral organs associated with hypercalcemia and metastatic calcification. One scan showed diffuse increased bone uptake (superscan pattern), and the other revealed focal metastatic bone uptake. Adenocarcinoma of unknown primary (AUP) origin was subsequently identified in both patients. AUP occurs in multiple organs more than 50% of the time, with bone involvement in 4% to 31% of cases. The patients described here reflect the variety of patterns of osseous and nonosseous uptake of diphosphonate bone agents in patients with AUP. |
| doi_str_mv | 10.1097/00003072-200009000-00030 |
| format | Article |
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Both scans showed abnormal soft tissue uptake in tumor deposits and in visceral organs associated with hypercalcemia and metastatic calcification. One scan showed diffuse increased bone uptake (superscan pattern), and the other revealed focal metastatic bone uptake. Adenocarcinoma of unknown primary (AUP) origin was subsequently identified in both patients. AUP occurs in multiple organs more than 50% of the time, with bone involvement in 4% to 31% of cases. The patients described here reflect the variety of patterns of osseous and nonosseous uptake of diphosphonate bone agents in patients with AUP.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-200009000-00030</identifier><identifier>PMID: 10983778</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - secondary ; Biological and medical sciences ; Bone and Bones - diagnostic imaging ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Diseases of the osteoarticular system ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Neoplasms, Unknown Primary - diagnostic imaging ; Osteoarticular system. 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Both scans showed abnormal soft tissue uptake in tumor deposits and in visceral organs associated with hypercalcemia and metastatic calcification. One scan showed diffuse increased bone uptake (superscan pattern), and the other revealed focal metastatic bone uptake. Adenocarcinoma of unknown primary (AUP) origin was subsequently identified in both patients. AUP occurs in multiple organs more than 50% of the time, with bone involvement in 4% to 31% of cases. The patients described here reflect the variety of patterns of osseous and nonosseous uptake of diphosphonate bone agents in patients with AUP.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - secondary</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Unknown Primary - diagnostic imaging</subject><subject>Osteoarticular system. Muscles</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals</subject><subject>Technetium Tc 99m Medronate</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPwzAMxyMEgvH4CigHxK3gJG3SHgHxFGJIsHPkpQmUdclINk18ezo6HhcsWY6sn-34b0IogxMGlTqFzgQonvHVq-o8-8pskAErhMyA82qTDEBIkVVK8h2ym9IbAJNM5ttkp2tSCqXKAbl7CD6kZMMi0dFsjhNLg6fnwVv6ZNDTxtOz2vpgMJrGhynS4OjIT3xYevoYmynGDzqMzUvj98mWwzbZg3XcI6Ory-eLm-x-eH17cXafGVEWkAklRSkcFmZsZeFykFxWpRtLYwXDmhkElVcWEI0zkMtSSAtunNeSY13mhdgjx33fWQzvC5vmetokY9sW_WoNrTgvGOfQgWUPmtitGK3Ts_7DmoFe6ai_ddQ_OuqvTFd6uJ6xGE9t_aewF64DjtYAJoOti-hNk365vJIMVIflPbYM7dzGNGkXSxv1q8V2_qr_O6P4BN5kiRc</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>CHEN, XIAOMING</creator><creator>JACOBSON, ARNOLD F</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>Nonosseous Uptake on Bone Scan in Adenocarcinoma of Unknown Primary Origin</title><author>CHEN, XIAOMING ; JACOBSON, ARNOLD F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3850-376383fa5cbe65f4062698fb6ce31ad1ca0749e0aacfc046836e0fb4d62ad8453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - secondary</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Diseases of the osteoarticular system</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms, Unknown Primary - diagnostic imaging</topic><topic>Osteoarticular system. Muscles</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Radiopharmaceuticals</topic><topic>Technetium Tc 99m Medronate</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, XIAOMING</creatorcontrib><creatorcontrib>JACOBSON, ARNOLD F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, XIAOMING</au><au>JACOBSON, ARNOLD F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonosseous Uptake on Bone Scan in Adenocarcinoma of Unknown Primary Origin</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>2000-09</date><risdate>2000</risdate><volume>25</volume><issue>9</issue><spage>751</spage><epage>752</epage><pages>751-752</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>Two patients without histories of cancer underwent Tc-99m MDP bone scans as part of evaluations of pain and abnormal laboratory and radiologic findings. Both scans showed abnormal soft tissue uptake in tumor deposits and in visceral organs associated with hypercalcemia and metastatic calcification. One scan showed diffuse increased bone uptake (superscan pattern), and the other revealed focal metastatic bone uptake. Adenocarcinoma of unknown primary (AUP) origin was subsequently identified in both patients. AUP occurs in multiple organs more than 50% of the time, with bone involvement in 4% to 31% of cases. The patients described here reflect the variety of patterns of osseous and nonosseous uptake of diphosphonate bone agents in patients with AUP.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10983778</pmid><doi>10.1097/00003072-200009000-00030</doi><tpages>2</tpages></addata></record> |
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| ispartof | Clinical nuclear medicine, 2000-09, Vol.25 (9), p.751-752 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - secondary Biological and medical sciences Bone and Bones - diagnostic imaging Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Diseases of the osteoarticular system Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Neoplasms, Unknown Primary - diagnostic imaging Osteoarticular system. Muscles Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals Technetium Tc 99m Medronate Tumors of striated muscle and skeleton |
| title | Nonosseous Uptake on Bone Scan in Adenocarcinoma of Unknown Primary Origin |
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