Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium

Chemokines and their receptors determine the distribution of leukocytes within tissues in health and disease. We have studied the role of the constitutive chemokine receptor CXCR4 and its ligand, stromal-derived factor-1 (SDF-1) in the perivascular accumulation of T cells in rheumatoid arthritis. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2000-09, Vol.165 (6), p.3423-3429
Hauptverfasser:	Buckley, C D, Amft, N, Bradfield, P F, Pilling, D, Ross, E, Arenzana-Seisdedos, F, Amara, A, Curnow, S J, Lord, J M, Scheel-Toellner, D, Salmon, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - immunology Cell Line Cell Movement - immunology Cells, Cultured Chemokine CXCL12 Chemokines, CXC - biosynthesis CXCR4 protein Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Humans Lymphocyte Activation - immunology Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - physiology SDF-1 protein stromal cell-derived factor 1 Stromal Cells - immunology Stromal Cells - metabolism Synovial Fluid - immunology Synovial Fluid - metabolism Synovial Membrane - blood supply Synovial Membrane - immunology Synovial Membrane - metabolism Synovial Membrane - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Transforming Growth Factor beta - physiology Transforming growth factor-^b1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!