HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line

The Nef protein has a major influence on disease pathogenesis in HIV-infected individuals. The objective of the present study was to examine the effects of Nef on T lymphocyte activation and associated signalling events. A recombinant vaccinia expression system was used to express Nef in a human T c...

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Veröffentlicht in:	AIDS (London) 2000-08, Vol.14 (12), p.1701-1707
Hauptverfasser:	SCHIBECI, S. D, CLEGG, A. O, BITI, R. A, SAGAWA, K, STEWART, G. J, WILLIAMSON, P
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences CD25 antigen CD28 Antigens Enzyme Activation Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation, Viral Gene Products, nef - genetics Gene Products, nef - physiology Genes, nef - physiology HIV-1 - genetics Human immunodeficiency virus Human viral diseases Humans Immunoblotting Infectious diseases Interleukin-2 - biosynthesis Interleukin-2 - metabolism Jurkat Cells Medical sciences nef Gene Products, Human Immunodeficiency Virus Nef protein Phosphatidylinositol 3-Kinases - metabolism Receptors, Interleukin-2 - biosynthesis Receptors, Interleukin-2 - immunology Signal Transduction T-Lymphocytes - enzymology T-Lymphocytes - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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