Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review
Abstract Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting. Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had receiv...
Gespeichert in:
| Veröffentlicht in: | Annals of clinical psychiatry 2000-09, Vol.12 (3), p.137-140 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | 3 |
| container_start_page | 137 |
| container_title | Annals of clinical psychiatry |
| container_volume | 12 |
| creator | Sporn, Jonathan Ghaemi, S. Nassir Sambur, Marnie R. Rankin, Meridith A. Recht, James Sachs, Gary S. Rosenbaum, Jerrold F. Fava, Maurizio |
| description | Abstract
Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.
Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had received pramipexole. Response was based on moderate to marked improvement in the Clinical Global Impression-Improvement (CGIT) scale.
Results: Pramipexole (mean dose 0.70 mg/d, mean duration 24.4 weeks) was effective in 6/12 (50.0%) of patients with bipolar depression, and 8/20 (40%) of patients with unipolar depression, mean duration of follow-up of 24.4 weeks. One case of transient hypomania was noted. Eight patients discontinued pramipexole due to lack of response and four due to side effects.
Conclusions: Pramipexole, used as an adjunct to antidepressants or mood stabilizers, appeared to be effective and safe in the treatment of unipolar and bipolar depression. These uncontrolled, retrospective, naturalistic pilot data require confirmation by controlled research before conclusions can be made. |
| doi_str_mv | 10.3109/10401230009147102 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72249565</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20635747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2832-b4358ecdc2516ac38ea806fe3e96c97c857574296e06c779267a17263f8c357e3</originalsourceid><addsrcrecordid>eNqFkVuLFDEQhRtR3HX1B_giQcS31tzT0adxvMKCIrvPTW2m2snQnfQm6VX_vRlmYEURn6qo-s6hitM0jxl9IRi1LxmVlHFBKbVMGkb5neaUKWlaIbi6W_u6bytgTpoHOe_2nO7U_eakijtJKT9tdl8STH7GH3FEslq-TRgKFB8D8YGULZKLhFD2UxIHchn8HEdIBMKGvDn2b3FOmHPVvCIr8hVLinlGV_wNkvUWUqmzG4_fHzb3BhgzPjrWs-by_buL9cf2_POHT-vVeet4J3h7JYXq0G0cV0yDEx1CR_WAAq121rhOGWUktxqpdsZYrg0ww7UYOieUQXHWPD_4zileL5hLP_nscBwhYFxybziXVmn1X5BTXQ2lqeDTP8BdXFKoT_ScMUuVFbJC7AC5-n9OOPRz8hOknz2j_T6u_q-4qubJ0Xi5mnDzm-KQTwWeHQHIDsYhQXA-33LS8mpasdcHzIchpgm2CGPZOkh4e-m_r_gFzy2tCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211905934</pqid></control><display><type>article</type><title>Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Sporn, Jonathan ; Ghaemi, S. Nassir ; Sambur, Marnie R. ; Rankin, Meridith A. ; Recht, James ; Sachs, Gary S. ; Rosenbaum, Jerrold F. ; Fava, Maurizio</creator><creatorcontrib>Sporn, Jonathan ; Ghaemi, S. Nassir ; Sambur, Marnie R. ; Rankin, Meridith A. ; Recht, James ; Sachs, Gary S. ; Rosenbaum, Jerrold F. ; Fava, Maurizio</creatorcontrib><description>Abstract
Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.
Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had received pramipexole. Response was based on moderate to marked improvement in the Clinical Global Impression-Improvement (CGIT) scale.
Results: Pramipexole (mean dose 0.70 mg/d, mean duration 24.4 weeks) was effective in 6/12 (50.0%) of patients with bipolar depression, and 8/20 (40%) of patients with unipolar depression, mean duration of follow-up of 24.4 weeks. One case of transient hypomania was noted. Eight patients discontinued pramipexole due to lack of response and four due to side effects.
Conclusions: Pramipexole, used as an adjunct to antidepressants or mood stabilizers, appeared to be effective and safe in the treatment of unipolar and bipolar depression. These uncontrolled, retrospective, naturalistic pilot data require confirmation by controlled research before conclusions can be made.</description><identifier>ISSN: 1040-1237</identifier><identifier>EISSN: 1547-3325</identifier><identifier>EISSN: 1573-3238</identifier><identifier>DOI: 10.3109/10401230009147102</identifier><identifier>PMID: 10984002</identifier><identifier>CODEN: APSYEZ</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Adult ; Benzothiazoles ; Biological and medical sciences ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Dopamine Agonists - pharmacology ; Dopamine Agonists - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Retrospective Studies ; Thiazoles - pharmacology ; Thiazoles - therapeutic use ; Treatment Outcome</subject><ispartof>Annals of clinical psychiatry, 2000-09, Vol.12 (3), p.137-140</ispartof><rights>2000 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2000</rights><rights>2000 INIST-CNRS</rights><rights>Copyright (c) 2000 American Academy of Clinical Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2832-b4358ecdc2516ac38ea806fe3e96c97c857574296e06c779267a17263f8c357e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1492040$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10984002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sporn, Jonathan</creatorcontrib><creatorcontrib>Ghaemi, S. Nassir</creatorcontrib><creatorcontrib>Sambur, Marnie R.</creatorcontrib><creatorcontrib>Rankin, Meridith A.</creatorcontrib><creatorcontrib>Recht, James</creatorcontrib><creatorcontrib>Sachs, Gary S.</creatorcontrib><creatorcontrib>Rosenbaum, Jerrold F.</creatorcontrib><creatorcontrib>Fava, Maurizio</creatorcontrib><title>Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review</title><title>Annals of clinical psychiatry</title><addtitle>Ann Clin Psychiatry</addtitle><description>Abstract
Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.
Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had received pramipexole. Response was based on moderate to marked improvement in the Clinical Global Impression-Improvement (CGIT) scale.
Results: Pramipexole (mean dose 0.70 mg/d, mean duration 24.4 weeks) was effective in 6/12 (50.0%) of patients with bipolar depression, and 8/20 (40%) of patients with unipolar depression, mean duration of follow-up of 24.4 weeks. One case of transient hypomania was noted. Eight patients discontinued pramipexole due to lack of response and four due to side effects.
Conclusions: Pramipexole, used as an adjunct to antidepressants or mood stabilizers, appeared to be effective and safe in the treatment of unipolar and bipolar depression. These uncontrolled, retrospective, naturalistic pilot data require confirmation by controlled research before conclusions can be made.</description><subject>Adult</subject><subject>Benzothiazoles</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - psychology</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Retrospective Studies</subject><subject>Thiazoles - pharmacology</subject><subject>Thiazoles - therapeutic use</subject><subject>Treatment Outcome</subject><issn>1040-1237</issn><issn>1547-3325</issn><issn>1573-3238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkVuLFDEQhRtR3HX1B_giQcS31tzT0adxvMKCIrvPTW2m2snQnfQm6VX_vRlmYEURn6qo-s6hitM0jxl9IRi1LxmVlHFBKbVMGkb5neaUKWlaIbi6W_u6bytgTpoHOe_2nO7U_eakijtJKT9tdl8STH7GH3FEslq-TRgKFB8D8YGULZKLhFD2UxIHchn8HEdIBMKGvDn2b3FOmHPVvCIr8hVLinlGV_wNkvUWUqmzG4_fHzb3BhgzPjrWs-by_buL9cf2_POHT-vVeet4J3h7JYXq0G0cV0yDEx1CR_WAAq121rhOGWUktxqpdsZYrg0ww7UYOieUQXHWPD_4zileL5hLP_nscBwhYFxybziXVmn1X5BTXQ2lqeDTP8BdXFKoT_ScMUuVFbJC7AC5-n9OOPRz8hOknz2j_T6u_q-4qubJ0Xi5mnDzm-KQTwWeHQHIDsYhQXA-33LS8mpasdcHzIchpgm2CGPZOkh4e-m_r_gFzy2tCg</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Sporn, Jonathan</creator><creator>Ghaemi, S. Nassir</creator><creator>Sambur, Marnie R.</creator><creator>Rankin, Meridith A.</creator><creator>Recht, James</creator><creator>Sachs, Gary S.</creator><creator>Rosenbaum, Jerrold F.</creator><creator>Fava, Maurizio</creator><general>Informa UK Ltd</general><general>Plenum Press</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review</title><author>Sporn, Jonathan ; Ghaemi, S. Nassir ; Sambur, Marnie R. ; Rankin, Meridith A. ; Recht, James ; Sachs, Gary S. ; Rosenbaum, Jerrold F. ; Fava, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2832-b4358ecdc2516ac38ea806fe3e96c97c857574296e06c779267a17263f8c357e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Benzothiazoles</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - psychology</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine Agonists - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Retrospective Studies</topic><topic>Thiazoles - pharmacology</topic><topic>Thiazoles - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sporn, Jonathan</creatorcontrib><creatorcontrib>Ghaemi, S. Nassir</creatorcontrib><creatorcontrib>Sambur, Marnie R.</creatorcontrib><creatorcontrib>Rankin, Meridith A.</creatorcontrib><creatorcontrib>Recht, James</creatorcontrib><creatorcontrib>Sachs, Gary S.</creatorcontrib><creatorcontrib>Rosenbaum, Jerrold F.</creatorcontrib><creatorcontrib>Fava, Maurizio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sporn, Jonathan</au><au>Ghaemi, S. Nassir</au><au>Sambur, Marnie R.</au><au>Rankin, Meridith A.</au><au>Recht, James</au><au>Sachs, Gary S.</au><au>Rosenbaum, Jerrold F.</au><au>Fava, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review</atitle><jtitle>Annals of clinical psychiatry</jtitle><addtitle>Ann Clin Psychiatry</addtitle><date>2000-09</date><risdate>2000</risdate><volume>12</volume><issue>3</issue><spage>137</spage><epage>140</epage><pages>137-140</pages><issn>1040-1237</issn><eissn>1547-3325</eissn><eissn>1573-3238</eissn><coden>APSYEZ</coden><abstract>Abstract
Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.
Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had received pramipexole. Response was based on moderate to marked improvement in the Clinical Global Impression-Improvement (CGIT) scale.
Results: Pramipexole (mean dose 0.70 mg/d, mean duration 24.4 weeks) was effective in 6/12 (50.0%) of patients with bipolar depression, and 8/20 (40%) of patients with unipolar depression, mean duration of follow-up of 24.4 weeks. One case of transient hypomania was noted. Eight patients discontinued pramipexole due to lack of response and four due to side effects.
Conclusions: Pramipexole, used as an adjunct to antidepressants or mood stabilizers, appeared to be effective and safe in the treatment of unipolar and bipolar depression. These uncontrolled, retrospective, naturalistic pilot data require confirmation by controlled research before conclusions can be made.</abstract><cop>London</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>10984002</pmid><doi>10.3109/10401230009147102</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1040-1237 |
| ispartof | Annals of clinical psychiatry, 2000-09, Vol.12 (3), p.137-140 |
| issn | 1040-1237 1547-3325 1573-3238 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72249565 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Benzothiazoles Biological and medical sciences Bipolar Disorder - drug therapy Bipolar Disorder - psychology Depressive Disorder - drug therapy Depressive Disorder - psychology Dopamine Agonists - pharmacology Dopamine Agonists - therapeutic use Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Retrospective Studies Thiazoles - pharmacology Thiazoles - therapeutic use Treatment Outcome |
| title | Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A21%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pramipexole%20Augmentation%20in%20the%20Treatment%20of%20Unipolar%20and%20Bipolar%20Depression:%20A%20Retrospective%20Chart%20Review&rft.jtitle=Annals%20of%20clinical%20psychiatry&rft.au=Sporn,%20Jonathan&rft.date=2000-09&rft.volume=12&rft.issue=3&rft.spage=137&rft.epage=140&rft.pages=137-140&rft.issn=1040-1237&rft.eissn=1547-3325&rft.coden=APSYEZ&rft_id=info:doi/10.3109/10401230009147102&rft_dat=%3Cproquest_cross%3E20635747%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211905934&rft_id=info:pmid/10984002&rfr_iscdi=true |