Diverse Effects of Hydrogen Peroxide on Cytosolic Ca2+ Homeostasis in Rat Pancreatic β-cells

Oxygen-free radicals are thought to be a major cause of β-cell dysfunction in diabetic animals induced by alloxan or streptozotocin. We evaluated the effect of H2O2 on cytosolic Ca2+ concentration ([Ca2+]i) and the activity of ATP-sensitive potassium (K+ATP) channels in isolated rat pancreatic β-cel...

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Veröffentlicht in:	Cell Structure and Function 2000, Vol.25(3), pp.187-193
Hauptverfasser:	Nakazaki, Mitsuhiro, Kakei, Masafumi, Yaekura, Kazuro, Koriyama, Nobuyuki, Morimitsu, Shingo, Ichinari, Kotaro, Yada, Toshihiko, Tei, Chuwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cell Membrane Permeability Chelating Agents - metabolism Cytophotometry Cytosol - metabolism cytosolic Ca2 Enzyme Inhibitors - pharmacology free radical Fura-2 - metabolism Homeostasis hydrogen peroxide Hydrogen Peroxide - pharmacology insulin secretion intracellular Ca2+ store Islets of Langerhans - drug effects Islets of Langerhans - metabolism NADP - metabolism pancreatic β-cells Patch-Clamp Techniques Potassium Channels - metabolism Rats Rats, Wistar Thapsigargin - pharmacology
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