Natural Development of Antibodies to Pneumococcal Surface Protein A, Pneumococcal Surface Adhesin A, and Pneumolysin in Relation to Pneumococcal Carriage and Acute Otitis Media
Pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA), and pneumolysin (Ply) are common to virtually all Streptococcus pneumoniae isolates. They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococc...
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| Veröffentlicht in: | The Journal of infectious diseases 2000-10, Vol.182 (4), p.1146-1152 |
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| container_title | The Journal of infectious diseases |
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| creator | Rapola, Satu Jäntti, Virva Haikala, Raili Syrjänen, Ritva Carlone, George M. Sampson, Jacquelyn S. Briles, David E. Paton, James C. Takala, Aino K. Kilpi, Terhi M. Käyhty, Helena |
| description | Pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA), and pneumolysin (Ply) are common to virtually all Streptococcus pneumoniae isolates. They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococcal vaccine for humans. However, little is known of the natural development of antibodies to these proteins in humans. The objective of this study was to evaluate the natural development of antibodies to PspA, PsaA, and Ply in relation to pneumococcal infection and carriage in young children. Serum antibodies to these proteins were measured by EIA in children at ages 6, 12, 18, and 24 months and in their mothers. All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media). |
| doi_str_mv | 10.1086/315822 |
| format | Article |
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They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococcal vaccine for humans. However, little is known of the natural development of antibodies to these proteins in humans. The objective of this study was to evaluate the natural development of antibodies to PspA, PsaA, and Ply in relation to pneumococcal infection and carriage in young children. Serum antibodies to these proteins were measured by EIA in children at ages 6, 12, 18, and 24 months and in their mothers. All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media).</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315822</identifier><identifier>PMID: 10979911</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adhesins, Bacterial ; Age ; Antibodies ; Antibodies, Bacterial - blood ; Antigens ; Antigens, Bacterial - immunology ; Bacterial diseases ; Bacterial Proteins - immunology ; Biological and medical sciences ; Carrier Proteins - immunology ; Carrier State - blood ; Carrier State - immunology ; Children ; Cohort Studies ; Finland ; Human bacterial diseases ; Humans ; Infant ; Infants ; Infectious diseases ; Lipoproteins - immunology ; Longitudinal Studies ; Major Articles ; Medical sciences ; Membrane proteins ; Membrane Transport Proteins ; Otitis media ; Otitis Media - blood ; Otitis Media - immunology ; Otitis Media - microbiology ; Ply protein ; Pneumococcal Infections - blood ; Pneumococcal Infections - immunology ; PsaA protein ; PspA protein ; Respiratory tract infections ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Streptolysins - immunology ; Vaccination</subject><ispartof>The Journal of infectious diseases, 2000-10, Vol.182 (4), p.1146-1152</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-e8dd1a9480858c0ec91f7b323cd83daf426007161a006b28c85df3c329a206b23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30110090$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30110090$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=970159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10979911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rapola, Satu</creatorcontrib><creatorcontrib>Jäntti, Virva</creatorcontrib><creatorcontrib>Haikala, Raili</creatorcontrib><creatorcontrib>Syrjänen, Ritva</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Sampson, Jacquelyn S.</creatorcontrib><creatorcontrib>Briles, David E.</creatorcontrib><creatorcontrib>Paton, James C.</creatorcontrib><creatorcontrib>Takala, Aino K.</creatorcontrib><creatorcontrib>Kilpi, Terhi M.</creatorcontrib><creatorcontrib>Käyhty, Helena</creatorcontrib><title>Natural Development of Antibodies to Pneumococcal Surface Protein A, Pneumococcal Surface Adhesin A, and Pneumolysin in Relation to Pneumococcal Carriage and Acute Otitis Media</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA), and pneumolysin (Ply) are common to virtually all Streptococcus pneumoniae isolates. They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococcal vaccine for humans. However, little is known of the natural development of antibodies to these proteins in humans. The objective of this study was to evaluate the natural development of antibodies to PspA, PsaA, and Ply in relation to pneumococcal infection and carriage in young children. Serum antibodies to these proteins were measured by EIA in children at ages 6, 12, 18, and 24 months and in their mothers. All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media).</description><subject>Adhesins, Bacterial</subject><subject>Age</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial diseases</subject><subject>Bacterial Proteins - immunology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - immunology</subject><subject>Carrier State - blood</subject><subject>Carrier State - immunology</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Finland</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Lipoproteins - immunology</subject><subject>Longitudinal Studies</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Membrane proteins</subject><subject>Membrane Transport Proteins</subject><subject>Otitis media</subject><subject>Otitis Media - blood</subject><subject>Otitis Media - immunology</subject><subject>Otitis Media - microbiology</subject><subject>Ply protein</subject><subject>Pneumococcal Infections - blood</subject><subject>Pneumococcal Infections - immunology</subject><subject>PsaA protein</subject><subject>PspA protein</subject><subject>Respiratory tract infections</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Streptolysins - immunology</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModlv1HygDQq8cPUl2JsnlsH5UabelKoo3IZuc0bSzkzXJiP1X_kRnnWUpKAiBwHmevBzyEvKIwnMKsn7BaSUZu0NmtOKirGvK75IZAGMllUodkMOUrgBgzmtxnxxQUEIpSmfk19LkIZqueIk_sAubNfa5CG3R9NmvgvOYihyKix6HdbDB2tF8P8TWWCwuYsjo-6J59m_euG-YJm56t3O6m-1oPJfYmexD_1f8wsTozVf886ixQ8biPPvsU3GGzpsH5F5ruoQPd_cR-fj61YfFSXl6_ubtojkt7VyxXKJ0jho1lyAraQGtoq1Yccatk9yZds5qAEFragDqFZNWVq7lljNl2HbAj8jxlLuJ4fuAKeu1Txa7zvQYhqQFY2M4Ff8V6biCqsWtRBtDShFbvYl-beKNpqC3JeqpxFF8skscVmt0t7SptVF4uhNMGr-sjaa3Pu09JYBWarQeT9ZVyiHuKQdKARSMvJy4Txl_7rmJ17oWXFT65PMXfabY5Tv2aamX_DefU7yi</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Rapola, Satu</creator><creator>Jäntti, Virva</creator><creator>Haikala, Raili</creator><creator>Syrjänen, Ritva</creator><creator>Carlone, George M.</creator><creator>Sampson, Jacquelyn S.</creator><creator>Briles, David E.</creator><creator>Paton, James C.</creator><creator>Takala, Aino K.</creator><creator>Kilpi, Terhi M.</creator><creator>Käyhty, Helena</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Natural Development of Antibodies to Pneumococcal Surface Protein A, Pneumococcal Surface Adhesin A, and Pneumolysin in Relation to Pneumococcal Carriage and Acute Otitis Media</title><author>Rapola, Satu ; Jäntti, Virva ; Haikala, Raili ; Syrjänen, Ritva ; Carlone, George M. ; Sampson, Jacquelyn S. ; Briles, David E. ; Paton, James C. ; Takala, Aino K. ; Kilpi, Terhi M. ; Käyhty, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-e8dd1a9480858c0ec91f7b323cd83daf426007161a006b28c85df3c329a206b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adhesins, Bacterial</topic><topic>Age</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial diseases</topic><topic>Bacterial Proteins - immunology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - immunology</topic><topic>Carrier State - blood</topic><topic>Carrier State - immunology</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Finland</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Lipoproteins - immunology</topic><topic>Longitudinal Studies</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Membrane proteins</topic><topic>Membrane Transport Proteins</topic><topic>Otitis media</topic><topic>Otitis Media - blood</topic><topic>Otitis Media - immunology</topic><topic>Otitis Media - microbiology</topic><topic>Ply protein</topic><topic>Pneumococcal Infections - blood</topic><topic>Pneumococcal Infections - immunology</topic><topic>PsaA protein</topic><topic>PspA protein</topic><topic>Respiratory tract infections</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Streptolysins - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rapola, Satu</creatorcontrib><creatorcontrib>Jäntti, Virva</creatorcontrib><creatorcontrib>Haikala, Raili</creatorcontrib><creatorcontrib>Syrjänen, Ritva</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Sampson, Jacquelyn S.</creatorcontrib><creatorcontrib>Briles, David E.</creatorcontrib><creatorcontrib>Paton, James C.</creatorcontrib><creatorcontrib>Takala, Aino K.</creatorcontrib><creatorcontrib>Kilpi, Terhi M.</creatorcontrib><creatorcontrib>Käyhty, Helena</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rapola, Satu</au><au>Jäntti, Virva</au><au>Haikala, Raili</au><au>Syrjänen, Ritva</au><au>Carlone, George M.</au><au>Sampson, Jacquelyn S.</au><au>Briles, David E.</au><au>Paton, James C.</au><au>Takala, Aino K.</au><au>Kilpi, Terhi M.</au><au>Käyhty, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Development of Antibodies to Pneumococcal Surface Protein A, Pneumococcal Surface Adhesin A, and Pneumolysin in Relation to Pneumococcal Carriage and Acute Otitis Media</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>182</volume><issue>4</issue><spage>1146</spage><epage>1152</epage><pages>1146-1152</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA), and pneumolysin (Ply) are common to virtually all Streptococcus pneumoniae isolates. They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococcal vaccine for humans. However, little is known of the natural development of antibodies to these proteins in humans. The objective of this study was to evaluate the natural development of antibodies to PspA, PsaA, and Ply in relation to pneumococcal infection and carriage in young children. Serum antibodies to these proteins were measured by EIA in children at ages 6, 12, 18, and 24 months and in their mothers. All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media).</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10979911</pmid><doi>10.1086/315822</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of infectious diseases, 2000-10, Vol.182 (4), p.1146-1152 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adhesins, Bacterial Age Antibodies Antibodies, Bacterial - blood Antigens Antigens, Bacterial - immunology Bacterial diseases Bacterial Proteins - immunology Biological and medical sciences Carrier Proteins - immunology Carrier State - blood Carrier State - immunology Children Cohort Studies Finland Human bacterial diseases Humans Infant Infants Infectious diseases Lipoproteins - immunology Longitudinal Studies Major Articles Medical sciences Membrane proteins Membrane Transport Proteins Otitis media Otitis Media - blood Otitis Media - immunology Otitis Media - microbiology Ply protein Pneumococcal Infections - blood Pneumococcal Infections - immunology PsaA protein PspA protein Respiratory tract infections Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Streptolysins - immunology Vaccination |
| title | Natural Development of Antibodies to Pneumococcal Surface Protein A, Pneumococcal Surface Adhesin A, and Pneumolysin in Relation to Pneumococcal Carriage and Acute Otitis Media |
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