Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage
Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 3...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular neuroscience 2000-06, Vol.14 (3), p.191-196 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 196 |
|---|---|
| container_issue | 3 |
| container_start_page | 191 |
| container_title | Journal of molecular neuroscience |
| container_volume | 14 |
| creator | Kim, H M Shin, H Y Jeong, H J An, H J Kim, N S Chae, H J Kim, H R Song, H J Kim, K Y Baek, S H Cho, K H Moon, B S Lee, Y M |
| description | Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism. |
| doi_str_mv | 10.1385/JMN:14:3:191 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72247988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2419995361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-fa80ed6ac89e8335f41caad1e9e5da8ebdfaeee426666ef6f8e9406005f424ef3</originalsourceid><addsrcrecordid>eNpdkUtLAzEQx4MoWqs3zxI8eOpqsptNk96k1BdVQfQc0uyk3bLdrXlU_PamtAdxDvP8MQzzR-iCkhtaiPL2-eV1RNmoGFFJD1CPCFlmgkt--Cc_QafeLwnJKaPiGJ1QIgWjsuyhzTtU0UCFn6ZZjmcxYGhgo8OuwwZbzwdYt6meT7AHF1c4EdB4XLd4rUMNbfD4uw4LbMDBzOkmTax2JtRdi6vo6naOwwKwNjEA9kHP4QwdWd14ON_HPvq8n3yMH7Pp28PT-G6amaIchsxqQaDi2ggJoihKy6jRuqIgoay0gFllNQCwnCcDy60AyQgnJJE5A1v00fVu79p1XxF8UKvaG2ga3UIXvRrmORtKIRJ49Q9cdtG16TYlBOU8z-UWGuwg4zrvHVi1dvVKux9FidqKoZIYijJVqCRGwi_3O-NsBdUfePf94hfquoRf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881662298</pqid></control><display><type>article</type><title>Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kim, H M ; Shin, H Y ; Jeong, H J ; An, H J ; Kim, N S ; Chae, H J ; Kim, H R ; Song, H J ; Kim, K Y ; Baek, S H ; Cho, K H ; Moon, B S ; Lee, Y M</creator><creatorcontrib>Kim, H M ; Shin, H Y ; Jeong, H J ; An, H J ; Kim, N S ; Chae, H J ; Kim, H R ; Song, H J ; Kim, K Y ; Baek, S H ; Cho, K H ; Moon, B S ; Lee, Y M</creatorcontrib><description>Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1385/JMN:14:3:191</identifier><identifier>PMID: 10984195</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Cerebral Infarction - blood ; Cerebral Infarction - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin E - blood ; Interferon-gamma - blood ; Interleukin-2 - blood ; Interleukin-4 - blood ; Interleukin-6 - blood ; Interleukins - blood ; Male ; Middle Aged ; Th1 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Journal of molecular neuroscience, 2000-06, Vol.14 (3), p.191-196</ispartof><rights>Humana Press Inc. 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fa80ed6ac89e8335f41caad1e9e5da8ebdfaeee426666ef6f8e9406005f424ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10984195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, H M</creatorcontrib><creatorcontrib>Shin, H Y</creatorcontrib><creatorcontrib>Jeong, H J</creatorcontrib><creatorcontrib>An, H J</creatorcontrib><creatorcontrib>Kim, N S</creatorcontrib><creatorcontrib>Chae, H J</creatorcontrib><creatorcontrib>Kim, H R</creatorcontrib><creatorcontrib>Song, H J</creatorcontrib><creatorcontrib>Kim, K Y</creatorcontrib><creatorcontrib>Baek, S H</creatorcontrib><creatorcontrib>Cho, K H</creatorcontrib><creatorcontrib>Moon, B S</creatorcontrib><creatorcontrib>Lee, Y M</creatorcontrib><title>Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><description>Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cerebral Infarction - blood</subject><subject>Cerebral Infarction - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-2 - blood</subject><subject>Interleukin-4 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>0895-8696</issn><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtLAzEQx4MoWqs3zxI8eOpqsptNk96k1BdVQfQc0uyk3bLdrXlU_PamtAdxDvP8MQzzR-iCkhtaiPL2-eV1RNmoGFFJD1CPCFlmgkt--Cc_QafeLwnJKaPiGJ1QIgWjsuyhzTtU0UCFn6ZZjmcxYGhgo8OuwwZbzwdYt6meT7AHF1c4EdB4XLd4rUMNbfD4uw4LbMDBzOkmTax2JtRdi6vo6naOwwKwNjEA9kHP4QwdWd14ON_HPvq8n3yMH7Pp28PT-G6amaIchsxqQaDi2ggJoihKy6jRuqIgoay0gFllNQCwnCcDy60AyQgnJJE5A1v00fVu79p1XxF8UKvaG2ga3UIXvRrmORtKIRJ49Q9cdtG16TYlBOU8z-UWGuwg4zrvHVi1dvVKux9FidqKoZIYijJVqCRGwi_3O-NsBdUfePf94hfquoRf</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Kim, H M</creator><creator>Shin, H Y</creator><creator>Jeong, H J</creator><creator>An, H J</creator><creator>Kim, N S</creator><creator>Chae, H J</creator><creator>Kim, H R</creator><creator>Song, H J</creator><creator>Kim, K Y</creator><creator>Baek, S H</creator><creator>Cho, K H</creator><creator>Moon, B S</creator><creator>Lee, Y M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage</title><author>Kim, H M ; Shin, H Y ; Jeong, H J ; An, H J ; Kim, N S ; Chae, H J ; Kim, H R ; Song, H J ; Kim, K Y ; Baek, S H ; Cho, K H ; Moon, B S ; Lee, Y M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fa80ed6ac89e8335f41caad1e9e5da8ebdfaeee426666ef6f8e9406005f424ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cerebral Infarction - blood</topic><topic>Cerebral Infarction - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-2 - blood</topic><topic>Interleukin-4 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Interleukins - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, H M</creatorcontrib><creatorcontrib>Shin, H Y</creatorcontrib><creatorcontrib>Jeong, H J</creatorcontrib><creatorcontrib>An, H J</creatorcontrib><creatorcontrib>Kim, N S</creatorcontrib><creatorcontrib>Chae, H J</creatorcontrib><creatorcontrib>Kim, H R</creatorcontrib><creatorcontrib>Song, H J</creatorcontrib><creatorcontrib>Kim, K Y</creatorcontrib><creatorcontrib>Baek, S H</creatorcontrib><creatorcontrib>Cho, K H</creatorcontrib><creatorcontrib>Moon, B S</creatorcontrib><creatorcontrib>Lee, Y M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, H M</au><au>Shin, H Y</au><au>Jeong, H J</au><au>An, H J</au><au>Kim, N S</au><au>Chae, H J</au><au>Kim, H R</au><au>Song, H J</au><au>Kim, K Y</au><au>Baek, S H</au><au>Cho, K H</au><au>Moon, B S</au><au>Lee, Y M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage</atitle><jtitle>Journal of molecular neuroscience</jtitle><addtitle>J Mol Neurosci</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>14</volume><issue>3</issue><spage>191</spage><epage>196</epage><pages>191-196</pages><issn>0895-8696</issn><eissn>0895-8696</eissn><eissn>1559-1166</eissn><abstract>Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>10984195</pmid><doi>10.1385/JMN:14:3:191</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-8696 |
| ispartof | Journal of molecular neuroscience, 2000-06, Vol.14 (3), p.191-196 |
| issn | 0895-8696 0895-8696 1559-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72247988 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Disease Adult Aged Aged, 80 and over Cerebral Infarction - blood Cerebral Infarction - immunology Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin E - blood Interferon-gamma - blood Interleukin-2 - blood Interleukin-4 - blood Interleukin-6 - blood Interleukins - blood Male Middle Aged Th1 Cells - immunology Th2 Cells - immunology |
| title | Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T00%3A18%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduced%20IL-2%20but%20elevated%20IL-4,%20IL-6,%20and%20IgE%20serum%20levels%20in%20patients%20with%20cerebral%20infarction%20during%20the%20acute%20stage&rft.jtitle=Journal%20of%20molecular%20neuroscience&rft.au=Kim,%20H%20M&rft.date=2000-06-01&rft.volume=14&rft.issue=3&rft.spage=191&rft.epage=196&rft.pages=191-196&rft.issn=0895-8696&rft.eissn=0895-8696&rft_id=info:doi/10.1385/JMN:14:3:191&rft_dat=%3Cproquest_cross%3E2419995361%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=881662298&rft_id=info:pmid/10984195&rfr_iscdi=true |