Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa

Pseudomonas aeruginosa PAO1 became considerably more sensitive to the action of ampicillin when grown in the presence of certain phospholipids. Only phospholipids capable of forming lipid bilayers or micelles proved to be capable of enhancing ampicillin activity. Of the phospholipids tested, 1-palmi...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2000-09, Vol.46 (3), p.377-384
Hauptverfasser:	Krogfelt, Karen A., Utley, Maryjane, Krivan, Howard C., Laux, David C., Cohen, Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Palmitoyl-2-hydroxy-n-glycero-3-phosphate Ampicillin - metabolism Ampicillin - pharmacology Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Calcium - metabolism Culture Media Cystic Fibrosis - microbiology Detergents - pharmacology Environmental Microbiology Fatty Acids - metabolism Fatty Acids - pharmacology General pharmacology Humans Magnesium - metabolism Medical sciences Microbial Sensitivity Tests Penicillins - metabolism Penicillins - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylserines - metabolism Phosphatidylserines - pharmacology Phospholipids - metabolism Phospholipids - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Pseudomonas Infections - microbiology
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