Effect of Rpe65 Knockout on Accumulation of Lipofuscin Fluorophores in the Retinal Pigment Epithelium

In all mammalian species examined to date the retinal pigment epithelium (RPE) has been found to accumulate autofluorescent lysosomal storage bodies (lipofuscin) during senescence. Substantial evidence indicates that retinoids in the RPE-retina complex play a major role in RPE lipofuscin formation....

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Veröffentlicht in:	Investigative ophthalmology & visual science 2001-11, Vol.42 (12), p.3023-3030
Hauptverfasser:	Katz, Martin L, Redmond, T. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carrier Proteins cis-trans-Isomerases Cytophotometry Eye Proteins - physiology Fatty Acids - metabolism Gene Deletion Lipofuscin - metabolism Medical sciences Mice Mice, Knockout Microscopy, Fluorescence Ophthalmology Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Proteins - physiology Retinaldehyde - metabolism Retinopathies
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