Gating of Store-Operated Channels by Conformational Coupling to Ryanodine Receptors

We report here that RyRs interact with and gate the store-operated hTrp3 and I crac channels. This gating contributes to activation of hTrp3 and I crac by agonists. Coupling of hTrp3 to IP 3Rs or RyRs in the same cells was found to be mutually exclusive. Biochemical and functional evidence suggest t...

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Veröffentlicht in:	Molecular cell 2000-08, Vol.6 (2), p.421-431
Hauptverfasser:	Kiselyov, Kirill I., Shin, Dong Min, Wang, Yaming, Pessah, Isaac N., Allen, Paul D., Muallem, Shmuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Barium - pharmacokinetics Caffeine - pharmacology Calcium - metabolism Calcium Channels - drug effects Calcium Channels - physiology Calcium Signaling Carbachol - pharmacology Cell Line Cell Membrane - physiology Heart - physiology Humans Ion Channel Gating - drug effects Ion Channel Gating - physiology Muscle, Skeletal - physiology Patch-Clamp Techniques Protein Isoforms - physiology Recombinant Proteins - drug effects Recombinant Proteins - metabolism Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - physiology Transfection TRPC Cation Channels
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