Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation: Analysis of 20, 000 Cases in Japan
In Japan, data on the epidemiological and clinical features of atrial fibrillation (AF) are rather sparse; even less data are available on the risk of thromboembolism in nonvalvular AF. The present study enrolled 19, 825 patients who visited the cardiovascular clinics of the 13 hospitals in Hokkaido...
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| Veröffentlicht in: | JAPANESE CIRCULATION JOURNAL 2000, Vol.64(9), pp.653-658 |
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| creator | Tomita, Fumishi Kohya, Tetsuro Sakurai, Masayuki Kaji, Tohru Yokoshiki, Hisashi Sato, Minoru Sasaki, Kohji Itoh, Yoshinori Konno, Masanori Kitabatake, Akira |
| description | In Japan, data on the epidemiological and clinical features of atrial fibrillation (AF) are rather sparse; even less data are available on the risk of thromboembolism in nonvalvular AF. The present study enrolled 19, 825 patients who visited the cardiovascular clinics of the 13 hospitals in Hokkaido, Japan, between March and July 1995. The prevalence of AF, the clinical characteristics of AF patients, and the occurrence of ischemic events were examined during the 2 year follow-up period. The prevalence of AF increased with age, and the overall prevalence was 14%. Antithrombotic therapy was used in 57% of AF patients and the incidence of ischemic events during the follow-up period was 4.6% in all AF patients. Warfarin reduced the risk of ischemic events in both the valvular and nonvalvular AF groups. A history of cerebrovascular accidents, advanced age, and the presence of underlying heart disease were each associated with a significantly increased risk of ischemic events in the nonvalvular AF group. These results show a lower incidence of ischemic events and more frequent use of antiplatelet drugs in the nonvalvular AF group. Further prospective studies are needed to determine the best preventive methods for thromboembolic complications in Japanese patients with nonvalvular AF. |
| doi_str_mv | 10.1253/jcj.64.653 |
| format | Article |
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The present study enrolled 19, 825 patients who visited the cardiovascular clinics of the 13 hospitals in Hokkaido, Japan, between March and July 1995. The prevalence of AF, the clinical characteristics of AF patients, and the occurrence of ischemic events were examined during the 2 year follow-up period. The prevalence of AF increased with age, and the overall prevalence was 14%. Antithrombotic therapy was used in 57% of AF patients and the incidence of ischemic events during the follow-up period was 4.6% in all AF patients. Warfarin reduced the risk of ischemic events in both the valvular and nonvalvular AF groups. A history of cerebrovascular accidents, advanced age, and the presence of underlying heart disease were each associated with a significantly increased risk of ischemic events in the nonvalvular AF group. These results show a lower incidence of ischemic events and more frequent use of antiplatelet drugs in the nonvalvular AF group. Further prospective studies are needed to determine the best preventive methods for thromboembolic complications in Japanese patients with nonvalvular AF.</description><identifier>ISSN: 0047-1828</identifier><identifier>EISSN: 1347-4839</identifier><identifier>DOI: 10.1253/jcj.64.653</identifier><identifier>PMID: 10981848</identifier><identifier>CODEN: JCIRA2</identifier><language>eng</language><publisher>Kyoto: The Japanese Circulation Society</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antithrombotic therapy ; Aspirin ; Atrial Fibrillation - complications ; Atrial Fibrillation - drug therapy ; Atrial Fibrillation - epidemiology ; Biological and medical sciences ; Cardiology. Vascular system ; Chi-Square Distribution ; Coronary heart disease ; Female ; Fibrinolytic Agents - therapeutic use ; Follow-Up Studies ; Heart ; Humans ; Incidence ; Ischemia - drug therapy ; Ischemia - etiology ; Ischemia - prevention & control ; Japan - epidemiology ; Male ; Medical sciences ; Middle Aged ; Nonvalvular atrial fibrillation ; Prevalence ; Prospective Studies ; Risk Factors ; Stroke ; Thromboembolism ; Thromboembolism - drug therapy ; Thromboembolism - etiology ; Thromboembolism - prevention & control ; Warfarin</subject><ispartof>JAPANESE CIRCULATION JOURNAL, 2000, Vol.64(9), pp.653-658</ispartof><rights>2000 THE JAPANESE CIRCULATION SOCIETY</rights><rights>2000 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-e4ea84c8979439d2b5b117873096e6ea3b81ec7ba8a3664b83205bc257a26cc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1529941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10981848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomita, Fumishi</creatorcontrib><creatorcontrib>Kohya, Tetsuro</creatorcontrib><creatorcontrib>Sakurai, Masayuki</creatorcontrib><creatorcontrib>Kaji, Tohru</creatorcontrib><creatorcontrib>Yokoshiki, Hisashi</creatorcontrib><creatorcontrib>Sato, Minoru</creatorcontrib><creatorcontrib>Sasaki, Kohji</creatorcontrib><creatorcontrib>Itoh, Yoshinori</creatorcontrib><creatorcontrib>Konno, Masanori</creatorcontrib><creatorcontrib>Kitabatake, Akira</creatorcontrib><creatorcontrib>Hokkaido Atrial Fibrillation Study Group</creatorcontrib><title>Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation: Analysis of 20, 000 Cases in Japan</title><title>JAPANESE CIRCULATION JOURNAL</title><addtitle>JAPANESE CIRCULATION JOURNAL</addtitle><description>In Japan, data on the epidemiological and clinical features of atrial fibrillation (AF) are rather sparse; even less data are available on the risk of thromboembolism in nonvalvular AF. 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Further prospective studies are needed to determine the best preventive methods for thromboembolic complications in Japanese patients with nonvalvular AF.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antithrombotic therapy</subject><subject>Aspirin</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Chi-Square Distribution</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Ischemia - drug therapy</subject><subject>Ischemia - etiology</subject><subject>Ischemia - prevention & control</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nonvalvular atrial fibrillation</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Thromboembolism</subject><subject>Thromboembolism - drug therapy</subject><subject>Thromboembolism - etiology</subject><subject>Thromboembolism - prevention & control</subject><subject>Warfarin</subject><issn>0047-1828</issn><issn>1347-4839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLAzEQx4MoWh8XP4DsQTwIrXlvcpJSfEFBD4rHMJtONWW7q0kq-O2NtD4uMwP_HzPDj5BjRkeMK3Gx8IuRliOtxBYZMCHroTTCbpMBpWVmhps9sp_SglJeS6V2yR6j1jAjzYBMHyJ-QIudxwq6WTVpQxc8tNXkFSL4jDGkHHyq-nn1ADlgl1P1HPJrNc4xFO46NDG0bYn67pDszKFNeLTpB-Tp-upxcjuc3t_cTcbToRdK5yFKBCO9sbWVws54oxrGalMLajVqBNEYhr5uwIDQWjZGcKoaz1UNXHtvxAE5W-99i_37ClN2y5A8li867FfJ1ZxLzaQo4Pka9LFPKeLcvcWwhPjpGHXf7lxx57R0xV2BTzZbV80SZ__QtawCnG4ASEXRPELnQ_rjFLdWsoJdrrFFyvCCvznEIrLFn5N2U8oTP4kvzh124gtVbI1C</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Tomita, Fumishi</creator><creator>Kohya, Tetsuro</creator><creator>Sakurai, Masayuki</creator><creator>Kaji, Tohru</creator><creator>Yokoshiki, Hisashi</creator><creator>Sato, Minoru</creator><creator>Sasaki, Kohji</creator><creator>Itoh, Yoshinori</creator><creator>Konno, Masanori</creator><creator>Kitabatake, Akira</creator><general>The Japanese Circulation Society</general><general>Japanese Circulation Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation</title><author>Tomita, Fumishi ; Kohya, Tetsuro ; Sakurai, Masayuki ; Kaji, Tohru ; Yokoshiki, Hisashi ; Sato, Minoru ; Sasaki, Kohji ; Itoh, Yoshinori ; Konno, Masanori ; Kitabatake, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e4ea84c8979439d2b5b117873096e6ea3b81ec7ba8a3664b83205bc257a26cc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antithrombotic therapy</topic><topic>Aspirin</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - drug therapy</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Chi-Square Distribution</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Ischemia - drug therapy</topic><topic>Ischemia - etiology</topic><topic>Ischemia - prevention & control</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nonvalvular atrial fibrillation</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Thromboembolism</topic><topic>Thromboembolism - drug therapy</topic><topic>Thromboembolism - etiology</topic><topic>Thromboembolism - prevention & control</topic><topic>Warfarin</topic><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Fumishi</creatorcontrib><creatorcontrib>Kohya, Tetsuro</creatorcontrib><creatorcontrib>Sakurai, Masayuki</creatorcontrib><creatorcontrib>Kaji, Tohru</creatorcontrib><creatorcontrib>Yokoshiki, Hisashi</creatorcontrib><creatorcontrib>Sato, Minoru</creatorcontrib><creatorcontrib>Sasaki, Kohji</creatorcontrib><creatorcontrib>Itoh, Yoshinori</creatorcontrib><creatorcontrib>Konno, Masanori</creatorcontrib><creatorcontrib>Kitabatake, Akira</creatorcontrib><creatorcontrib>Hokkaido Atrial Fibrillation Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JAPANESE CIRCULATION JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Fumishi</au><au>Kohya, Tetsuro</au><au>Sakurai, Masayuki</au><au>Kaji, Tohru</au><au>Yokoshiki, Hisashi</au><au>Sato, Minoru</au><au>Sasaki, Kohji</au><au>Itoh, Yoshinori</au><au>Konno, Masanori</au><au>Kitabatake, Akira</au><aucorp>Hokkaido Atrial Fibrillation Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation: Analysis of 20, 000 Cases in Japan</atitle><jtitle>JAPANESE CIRCULATION JOURNAL</jtitle><addtitle>JAPANESE CIRCULATION JOURNAL</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>64</volume><issue>9</issue><spage>653</spage><epage>658</epage><pages>653-658</pages><issn>0047-1828</issn><eissn>1347-4839</eissn><coden>JCIRA2</coden><abstract>In Japan, data on the epidemiological and clinical features of atrial fibrillation (AF) are rather sparse; even less data are available on the risk of thromboembolism in nonvalvular AF. The present study enrolled 19, 825 patients who visited the cardiovascular clinics of the 13 hospitals in Hokkaido, Japan, between March and July 1995. The prevalence of AF, the clinical characteristics of AF patients, and the occurrence of ischemic events were examined during the 2 year follow-up period. The prevalence of AF increased with age, and the overall prevalence was 14%. Antithrombotic therapy was used in 57% of AF patients and the incidence of ischemic events during the follow-up period was 4.6% in all AF patients. Warfarin reduced the risk of ischemic events in both the valvular and nonvalvular AF groups. A history of cerebrovascular accidents, advanced age, and the presence of underlying heart disease were each associated with a significantly increased risk of ischemic events in the nonvalvular AF group. These results show a lower incidence of ischemic events and more frequent use of antiplatelet drugs in the nonvalvular AF group. Further prospective studies are needed to determine the best preventive methods for thromboembolic complications in Japanese patients with nonvalvular AF.</abstract><cop>Kyoto</cop><pub>The Japanese Circulation Society</pub><pmid>10981848</pmid><doi>10.1253/jcj.64.653</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antithrombotic therapy Aspirin Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Atrial Fibrillation - epidemiology Biological and medical sciences Cardiology. Vascular system Chi-Square Distribution Coronary heart disease Female Fibrinolytic Agents - therapeutic use Follow-Up Studies Heart Humans Incidence Ischemia - drug therapy Ischemia - etiology Ischemia - prevention & control Japan - epidemiology Male Medical sciences Middle Aged Nonvalvular atrial fibrillation Prevalence Prospective Studies Risk Factors Stroke Thromboembolism Thromboembolism - drug therapy Thromboembolism - etiology Thromboembolism - prevention & control Warfarin |
| title | Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation: Analysis of 20, 000 Cases in Japan |
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