Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status
We have carried out a retrospective, multicentre, chart-review trial, in which all the patients meeting pre-established inclusion criteria and treated in the three participating centres with either splenectomy or low-dose splenic irradiation were enrolled. Inclusion criteria were: long-lasting, symp...
Gespeichert in:
| Veröffentlicht in: | AIDS (London) 2000-07, Vol.14 (11), p.1664-1667 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1667 |
|---|---|
| container_issue | 11 |
| container_start_page | 1664 |
| container_title | AIDS (London) |
| container_volume | 14 |
| creator | MARRONI, M SILVA SINNONE, M LANDONIO, G ARISTEI, C BOSCHETTI, E LAZZARIN, A GRESELE, P |
| description | We have carried out a retrospective, multicentre, chart-review trial, in which all the patients meeting pre-established inclusion criteria and treated in the three participating centres with either splenectomy or low-dose splenic irradiation were enrolled. Inclusion criteria were: long-lasting, symptomatic, severe thrombocytopenia ( |
| doi_str_mv | 10.1097/00002030-200007280-00027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72245525</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17621654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-b37e1d893202f67c3ba24147329bb6bd366dc4866d378494651792e0db1ab3a33</originalsourceid><addsrcrecordid>eNqFkcmO1DAQhi0EYpqBV0A-IE4EvMRLuKERMCONxIHlGtlOBYySONgOUj8Fr0yFbpYbPtilqq9-2_UTQjl7zllnXjBcgknWiD0ywrJmz5g75MBbIxulDL9LDkzorumkYRfkQSlfEVHM2vvkAkWs1MoeyI_36wRLDDTm7IboakwL_Q65bIWWvQShpvlIx5RpASzAM5phzA7T-Uivbz41GSZXYaD1S06zT-FY04qS7iWFccT2QlFy3ZkJKg1pWzDlloHGed6WNKXPMbiJlurqVh6Se6ObCjw6n5fk45vXH66um9t3b2-uXt02oRW8Nl4a4IPtpGBi1CZI70S7f1103ms_SK2H0FrcpbFt12rFTSeADZ47L52Ul-TpSXfN6dsGpfZzLAGmyS2QttIbIVqlhPovyI0WXKsWQXsCQ06l4Iz6NcfZ5WPPWb-71v92rf_jWv_LNWx9fL5j8zMM_zSebELgyRlwBWeF419CLH85fKiSnfwJYwih8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17621654</pqid></control><display><type>article</type><title>Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>MARRONI, M ; SILVA SINNONE, M ; LANDONIO, G ; ARISTEI, C ; BOSCHETTI, E ; LAZZARIN, A ; GRESELE, P</creator><creatorcontrib>MARRONI, M ; SILVA SINNONE, M ; LANDONIO, G ; ARISTEI, C ; BOSCHETTI, E ; LAZZARIN, A ; GRESELE, P</creatorcontrib><description>We have carried out a retrospective, multicentre, chart-review trial, in which all the patients meeting pre-established inclusion criteria and treated in the three participating centres with either splenectomy or low-dose splenic irradiation were enrolled. Inclusion criteria were: long-lasting, symptomatic, severe thrombocytopenia (<25 x 10 super(9)/l), refractory to previous treatments (zidovudine; corticosteroids; vincristine; danazol; high-dose intravenous IgG; high-dose dexamethasone or IFN- alpha ) and a CD4 cell count higher than 50 x 10 super(6)/l. Exclusion criteria were: reduced bone marrow megakaryocytes; liver cirrhosis; granulocytes lower than 3 x 10 super(9)/l or haemoglobin lower than 110 g/l; allergy to pneumococcal vaccine or to cephalosporins. Patient records were analysed for a follow-up of 6 months by independent reviewers.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200007280-00027</identifier><identifier>PMID: 10983658</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; AIDS/HIV ; Biological and medical sciences ; Female ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Platelet Count ; Retrospective Studies ; Spleen - immunology ; Spleen - radiation effects ; Spleen - surgery ; Splenectomy ; Thrombocytopenia - complications ; Thrombocytopenia - immunology ; Thrombocytopenia - radiotherapy ; Thrombocytopenia - therapy ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2000-07, Vol.14 (11), p.1664-1667</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-b37e1d893202f67c3ba24147329bb6bd366dc4866d378494651792e0db1ab3a33</citedby><cites>FETCH-LOGICAL-c421t-b37e1d893202f67c3ba24147329bb6bd366dc4866d378494651792e0db1ab3a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1525539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10983658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARRONI, M</creatorcontrib><creatorcontrib>SILVA SINNONE, M</creatorcontrib><creatorcontrib>LANDONIO, G</creatorcontrib><creatorcontrib>ARISTEI, C</creatorcontrib><creatorcontrib>BOSCHETTI, E</creatorcontrib><creatorcontrib>LAZZARIN, A</creatorcontrib><creatorcontrib>GRESELE, P</creatorcontrib><title>Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>We have carried out a retrospective, multicentre, chart-review trial, in which all the patients meeting pre-established inclusion criteria and treated in the three participating centres with either splenectomy or low-dose splenic irradiation were enrolled. Inclusion criteria were: long-lasting, symptomatic, severe thrombocytopenia (<25 x 10 super(9)/l), refractory to previous treatments (zidovudine; corticosteroids; vincristine; danazol; high-dose intravenous IgG; high-dose dexamethasone or IFN- alpha ) and a CD4 cell count higher than 50 x 10 super(6)/l. Exclusion criteria were: reduced bone marrow megakaryocytes; liver cirrhosis; granulocytes lower than 3 x 10 super(9)/l or haemoglobin lower than 110 g/l; allergy to pneumococcal vaccine or to cephalosporins. Patient records were analysed for a follow-up of 6 months by independent reviewers.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Platelet Count</subject><subject>Retrospective Studies</subject><subject>Spleen - immunology</subject><subject>Spleen - radiation effects</subject><subject>Spleen - surgery</subject><subject>Splenectomy</subject><subject>Thrombocytopenia - complications</subject><subject>Thrombocytopenia - immunology</subject><subject>Thrombocytopenia - radiotherapy</subject><subject>Thrombocytopenia - therapy</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcmO1DAQhi0EYpqBV0A-IE4EvMRLuKERMCONxIHlGtlOBYySONgOUj8Fr0yFbpYbPtilqq9-2_UTQjl7zllnXjBcgknWiD0ywrJmz5g75MBbIxulDL9LDkzorumkYRfkQSlfEVHM2vvkAkWs1MoeyI_36wRLDDTm7IboakwL_Q65bIWWvQShpvlIx5RpASzAM5phzA7T-Uivbz41GSZXYaD1S06zT-FY04qS7iWFccT2QlFy3ZkJKg1pWzDlloHGed6WNKXPMbiJlurqVh6Se6ObCjw6n5fk45vXH66um9t3b2-uXt02oRW8Nl4a4IPtpGBi1CZI70S7f1103ms_SK2H0FrcpbFt12rFTSeADZ47L52Ul-TpSXfN6dsGpfZzLAGmyS2QttIbIVqlhPovyI0WXKsWQXsCQ06l4Iz6NcfZ5WPPWb-71v92rf_jWv_LNWx9fL5j8zMM_zSebELgyRlwBWeF419CLH85fKiSnfwJYwih8Q</recordid><startdate>20000728</startdate><enddate>20000728</enddate><creator>MARRONI, M</creator><creator>SILVA SINNONE, M</creator><creator>LANDONIO, G</creator><creator>ARISTEI, C</creator><creator>BOSCHETTI, E</creator><creator>LAZZARIN, A</creator><creator>GRESELE, P</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000728</creationdate><title>Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status</title><author>MARRONI, M ; SILVA SINNONE, M ; LANDONIO, G ; ARISTEI, C ; BOSCHETTI, E ; LAZZARIN, A ; GRESELE, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-b37e1d893202f67c3ba24147329bb6bd366dc4866d378494651792e0db1ab3a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Platelet Count</topic><topic>Retrospective Studies</topic><topic>Spleen - immunology</topic><topic>Spleen - radiation effects</topic><topic>Spleen - surgery</topic><topic>Splenectomy</topic><topic>Thrombocytopenia - complications</topic><topic>Thrombocytopenia - immunology</topic><topic>Thrombocytopenia - radiotherapy</topic><topic>Thrombocytopenia - therapy</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARRONI, M</creatorcontrib><creatorcontrib>SILVA SINNONE, M</creatorcontrib><creatorcontrib>LANDONIO, G</creatorcontrib><creatorcontrib>ARISTEI, C</creatorcontrib><creatorcontrib>BOSCHETTI, E</creatorcontrib><creatorcontrib>LAZZARIN, A</creatorcontrib><creatorcontrib>GRESELE, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARRONI, M</au><au>SILVA SINNONE, M</au><au>LANDONIO, G</au><au>ARISTEI, C</au><au>BOSCHETTI, E</au><au>LAZZARIN, A</au><au>GRESELE, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2000-07-28</date><risdate>2000</risdate><volume>14</volume><issue>11</issue><spage>1664</spage><epage>1667</epage><pages>1664-1667</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>We have carried out a retrospective, multicentre, chart-review trial, in which all the patients meeting pre-established inclusion criteria and treated in the three participating centres with either splenectomy or low-dose splenic irradiation were enrolled. Inclusion criteria were: long-lasting, symptomatic, severe thrombocytopenia (<25 x 10 super(9)/l), refractory to previous treatments (zidovudine; corticosteroids; vincristine; danazol; high-dose intravenous IgG; high-dose dexamethasone or IFN- alpha ) and a CD4 cell count higher than 50 x 10 super(6)/l. Exclusion criteria were: reduced bone marrow megakaryocytes; liver cirrhosis; granulocytes lower than 3 x 10 super(9)/l or haemoglobin lower than 110 g/l; allergy to pneumococcal vaccine or to cephalosporins. Patient records were analysed for a follow-up of 6 months by independent reviewers.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10983658</pmid><doi>10.1097/00002030-200007280-00027</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2000-07, Vol.14 (11), p.1664-1667 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72245525 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult AIDS/HIV Biological and medical sciences Female HIV Infections - blood HIV Infections - complications HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Platelet Count Retrospective Studies Spleen - immunology Spleen - radiation effects Spleen - surgery Splenectomy Thrombocytopenia - complications Thrombocytopenia - immunology Thrombocytopenia - radiotherapy Thrombocytopenia - therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Splenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological status |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T18%3A42%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Splenic%20irradiation%20versus%20splenectomy%20for%20severe,%20refractory%20HIV-related%20thrombocytopenia:%20effects%20on%20platelet%20counts%20and%20immunological%20status&rft.jtitle=AIDS%20(London)&rft.au=MARRONI,%20M&rft.date=2000-07-28&rft.volume=14&rft.issue=11&rft.spage=1664&rft.epage=1667&rft.pages=1664-1667&rft.issn=0269-9370&rft.eissn=1473-5571&rft_id=info:doi/10.1097/00002030-200007280-00027&rft_dat=%3Cproquest_cross%3E17621654%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17621654&rft_id=info:pmid/10983658&rfr_iscdi=true |