Colostral whey concentrate supplement increases complement activity in the sera of neonatal calves
We evaluated the effect of a commercial bovine colostral whey on the complement-mediated immune responses of calves. Two groups of neonatal calves were fed, in addition to whole milk (WM) and pooled colostrum (PC), different amounts of a commercial immunoglobulin concentrate made from pooled colostr...
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| Veröffentlicht in: | Journal of dairy research 2001-08, Vol.68 (3), p.357-367 |
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| creator | ROKKA, SUSANNA KORHONEN, HANNU NOUSIAINEN, JUHA MARNILA, PERTTI |
| description | We evaluated the effect of a commercial bovine colostral whey on the complement-mediated immune responses of calves. Two groups of neonatal calves were fed, in addition to whole milk (WM) and pooled colostrum (PC), different amounts of a commercial immunoglobulin concentrate made from pooled colostral whey (Ig-C) for the first two feedings post natum. The control group was fed WM and PC only. Serum samples were obtained at the ages of 2, 7, 14 and 30 d. Bacteriolytic activity against complement-sensitive Escherichia coli JM103 and opsonic activity against complement-lysis-resistant E. coli IH3080 strains were studied, as well as the levels of C3 complement component and E. coli JM103 specific antibodies in the sera. Groups fed Ig-C had 2–3 times higher bacteriolytic activity than the control group of both the classic (P < 0·005) and alternative pathways (P < 0·0001) at days 2 and 7 post natum. This effect is obviously not caused solely by the antibodies ingested but also involves other unknown colostral factors, possibly lectins. The opsonisation capacities of the sera correlated well with the amounts of immunoglobulins ingested (P < 0·05) at days 2–14. The levels of C3 component in sera did not differ between the groups. In the group fed the largest amount of immunoglobulins levels of E. coli JM103-specific antibodies were highest (P < 0·0001). It can thus be concluded that the antibody independent complement activities of serum can be increased substantially by feeding colostral whey concentrate to calves during their first days of life. |
| doi_str_mv | 10.1017/S0022029901004952 |
| format | Article |
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Two groups of neonatal calves were fed, in addition to whole milk (WM) and pooled colostrum (PC), different amounts of a commercial immunoglobulin concentrate made from pooled colostral whey (Ig-C) for the first two feedings post natum. The control group was fed WM and PC only. Serum samples were obtained at the ages of 2, 7, 14 and 30 d. Bacteriolytic activity against complement-sensitive Escherichia coli JM103 and opsonic activity against complement-lysis-resistant E. coli IH3080 strains were studied, as well as the levels of C3 complement component and E. coli JM103 specific antibodies in the sera. Groups fed Ig-C had 2–3 times higher bacteriolytic activity than the control group of both the classic (P < 0·005) and alternative pathways (P < 0·0001) at days 2 and 7 post natum. This effect is obviously not caused solely by the antibodies ingested but also involves other unknown colostral factors, possibly lectins. The opsonisation capacities of the sera correlated well with the amounts of immunoglobulins ingested (P < 0·05) at days 2–14. The levels of C3 component in sera did not differ between the groups. In the group fed the largest amount of immunoglobulins levels of E. coli JM103-specific antibodies were highest (P < 0·0001). It can thus be concluded that the antibody independent complement activities of serum can be increased substantially by feeding colostral whey concentrate to calves during their first days of life.</description><identifier>ISSN: 0022-0299</identifier><identifier>EISSN: 1469-7629</identifier><identifier>DOI: 10.1017/S0022029901004952</identifier><identifier>PMID: 11694039</identifier><identifier>CODEN: JDRSAN</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Age Factors ; Animals ; Animals, Newborn ; Antibodies, Bacterial - blood ; bacteriolysis ; Bacteriolysis - immunology ; Biological and medical sciences ; Blood Bactericidal Activity ; calf ; Cattle - blood ; Cattle - immunology ; Cattle Diseases - immunology ; Cattle Diseases - prevention & control ; Colostral whey ; Colostrum - immunology ; Complement ; Complement System Proteins - immunology ; E coli ; Escherichia coli - immunology ; Escherichia coli Infections - immunology ; Escherichia coli Infections - prevention & control ; Escherichia coli Infections - veterinary ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunoglobulins - administration & dosage ; Immunoglobulins - blood ; Molecular immunology ; opsonization ; Original article ; Random Allocation</subject><ispartof>Journal of dairy research, 2001-08, Vol.68 (3), p.357-367</ispartof><rights>Proprietors of Journal of Dairy Research 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-2198b1694ea244a8819ba09799f8246906472f248ebc0d9b001b0dcb55d1bb173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022029901004952/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14069857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11694039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROKKA, SUSANNA</creatorcontrib><creatorcontrib>KORHONEN, HANNU</creatorcontrib><creatorcontrib>NOUSIAINEN, JUHA</creatorcontrib><creatorcontrib>MARNILA, PERTTI</creatorcontrib><title>Colostral whey concentrate supplement increases complement activity in the sera of neonatal calves</title><title>Journal of dairy research</title><addtitle>Journal of Dairy Research</addtitle><description>We evaluated the effect of a commercial bovine colostral whey on the complement-mediated immune responses of calves. Two groups of neonatal calves were fed, in addition to whole milk (WM) and pooled colostrum (PC), different amounts of a commercial immunoglobulin concentrate made from pooled colostral whey (Ig-C) for the first two feedings post natum. The control group was fed WM and PC only. Serum samples were obtained at the ages of 2, 7, 14 and 30 d. Bacteriolytic activity against complement-sensitive Escherichia coli JM103 and opsonic activity against complement-lysis-resistant E. coli IH3080 strains were studied, as well as the levels of C3 complement component and E. coli JM103 specific antibodies in the sera. Groups fed Ig-C had 2–3 times higher bacteriolytic activity than the control group of both the classic (P < 0·005) and alternative pathways (P < 0·0001) at days 2 and 7 post natum. This effect is obviously not caused solely by the antibodies ingested but also involves other unknown colostral factors, possibly lectins. The opsonisation capacities of the sera correlated well with the amounts of immunoglobulins ingested (P < 0·05) at days 2–14. The levels of C3 component in sera did not differ between the groups. In the group fed the largest amount of immunoglobulins levels of E. coli JM103-specific antibodies were highest (P < 0·0001). It can thus be concluded that the antibody independent complement activities of serum can be increased substantially by feeding colostral whey concentrate to calves during their first days of life.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies, Bacterial - blood</subject><subject>bacteriolysis</subject><subject>Bacteriolysis - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity</subject><subject>calf</subject><subject>Cattle - blood</subject><subject>Cattle - immunology</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - prevention & control</subject><subject>Colostral whey</subject><subject>Colostrum - immunology</subject><subject>Complement</subject><subject>Complement System Proteins - immunology</subject><subject>E coli</subject><subject>Escherichia coli - immunology</subject><subject>Escherichia coli Infections - immunology</subject><subject>Escherichia coli Infections - prevention & control</subject><subject>Escherichia coli Infections - veterinary</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunoglobulins - administration & dosage</subject><subject>Immunoglobulins - blood</subject><subject>Molecular immunology</subject><subject>opsonization</subject><subject>Original article</subject><subject>Random Allocation</subject><issn>0022-0299</issn><issn>1469-7629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE9v1DAQxS0EotvCB-CCIqRySzt2HDs-olVpkSpVVQtXy3YmNG3-bG2nsN8eRxu6UhEna_x-M3rvEfKBwgkFKk9vABgDphRQAK5K9oqsKBcql4Kp12Q1y_msH5DDEO4BaAFKvCUHlArFoVArYtdjN4boTZf9usNt5sbB4ZDmiFmYNpsO-zRm7eA8moAhAf3fT-Ni-9TGbVKzeJd49CYbm2zAcTAxXXSme8LwjrxpTBfw_fIeke9fz27XF_nl1fm39ZfL3PFCxJxRVdnZFxrGuakqqqwBJZVqKpZCgeCSNYxXaB3UyqY0Fmpny7Km1lJZHJHPu7sbPz5OGKLu2-Cw60wyNAUtWborS5HATy_A-3HyQ_KmGZNKcMF4gugOcn4MwWOjN77tjd9qCnpuX__Tftr5uByebI_1fmOpOwHHC2BCKqfxZnBt2HMchKrKOUq-49oQ8fezbvyDFrKQpRbn11rQ4lrI6oe-TXyxmDW99W39E_eR_m_3Dy-6qjY</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>ROKKA, SUSANNA</creator><creator>KORHONEN, HANNU</creator><creator>NOUSIAINEN, JUHA</creator><creator>MARNILA, PERTTI</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Colostral whey concentrate supplement increases complement activity in the sera of neonatal calves</title><author>ROKKA, SUSANNA ; KORHONEN, HANNU ; NOUSIAINEN, JUHA ; MARNILA, PERTTI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-2198b1694ea244a8819ba09799f8246906472f248ebc0d9b001b0dcb55d1bb173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies, Bacterial - blood</topic><topic>bacteriolysis</topic><topic>Bacteriolysis - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood Bactericidal Activity</topic><topic>calf</topic><topic>Cattle - blood</topic><topic>Cattle - immunology</topic><topic>Cattle Diseases - immunology</topic><topic>Cattle Diseases - prevention & control</topic><topic>Colostral whey</topic><topic>Colostrum - immunology</topic><topic>Complement</topic><topic>Complement System Proteins - immunology</topic><topic>E coli</topic><topic>Escherichia coli - immunology</topic><topic>Escherichia coli Infections - immunology</topic><topic>Escherichia coli Infections - prevention & control</topic><topic>Escherichia coli Infections - veterinary</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Two groups of neonatal calves were fed, in addition to whole milk (WM) and pooled colostrum (PC), different amounts of a commercial immunoglobulin concentrate made from pooled colostral whey (Ig-C) for the first two feedings post natum. The control group was fed WM and PC only. Serum samples were obtained at the ages of 2, 7, 14 and 30 d. Bacteriolytic activity against complement-sensitive Escherichia coli JM103 and opsonic activity against complement-lysis-resistant E. coli IH3080 strains were studied, as well as the levels of C3 complement component and E. coli JM103 specific antibodies in the sera. Groups fed Ig-C had 2–3 times higher bacteriolytic activity than the control group of both the classic (P < 0·005) and alternative pathways (P < 0·0001) at days 2 and 7 post natum. This effect is obviously not caused solely by the antibodies ingested but also involves other unknown colostral factors, possibly lectins. The opsonisation capacities of the sera correlated well with the amounts of immunoglobulins ingested (P < 0·05) at days 2–14. The levels of C3 component in sera did not differ between the groups. In the group fed the largest amount of immunoglobulins levels of E. coli JM103-specific antibodies were highest (P < 0·0001). It can thus be concluded that the antibody independent complement activities of serum can be increased substantially by feeding colostral whey concentrate to calves during their first days of life.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>11694039</pmid><doi>10.1017/S0022029901004952</doi><tpages>11</tpages></addata></record> |
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| subjects | Age Factors Animals Animals, Newborn Antibodies, Bacterial - blood bacteriolysis Bacteriolysis - immunology Biological and medical sciences Blood Bactericidal Activity calf Cattle - blood Cattle - immunology Cattle Diseases - immunology Cattle Diseases - prevention & control Colostral whey Colostrum - immunology Complement Complement System Proteins - immunology E coli Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Escherichia coli Infections - veterinary Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoglobulins - administration & dosage Immunoglobulins - blood Molecular immunology opsonization Original article Random Allocation |
| title | Colostral whey concentrate supplement increases complement activity in the sera of neonatal calves |
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