Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus

Antiangiogenic therapy using Semliki Forest virus (SFV) carrying Endostatin gene for malignant brain tumor was investigated to improve the therapeutic efficacy. The efficiency of SFV-mediated gene delivery was first evaluated for B 16 cells and compared with the efficiency in cells of endothelial or...

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Veröffentlicht in:	Cancer gene therapy 2001-10, Vol.8 (10), p.796-802
Hauptverfasser:	Yamanaka, R, Zullo, S A, Ramsey, J, Onodera, M, Tanaka, R, Blaese, M, Xanthopoulos, K G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals antiangiogenic factors Brain cancer Brain Neoplasms - blood supply Brain Neoplasms - therapy Brain Neoplasms - virology Brain tumors Cells, Cultured Collagen - blood Collagen - genetics Endostatin Endostatins Endothelium, Vascular - metabolism Endothelium, Vascular - virology Female Gene Expression Gene therapy Gene transfer Gene Transfer Techniques Genetic engineering Genetic Therapy - methods Genetic Vectors - administration & dosage Humans Intravenous administration Melanoma, Experimental - blood supply Melanoma, Experimental - therapy Melanoma, Experimental - virology Mice Mice, Inbred C57BL Mice, Nude Neovascularization, Pathologic - therapy Peptide Fragments - blood Peptide Fragments - genetics Reverse Transcriptase Polymerase Chain Reaction Semliki Forest virus Semliki forest virus - physiology Survival Rate Tumors Vascularization
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