Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential

Synthesized 6-arylamino-5,8-quinolinediones 4a-4j and 6-chloro-7-arylamino-5,8-isoquinolinediones 5a-5g were evaluated for effects on NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several...

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Veröffentlicht in:	Archives of pharmacal research 2001-10, Vol.24 (5), p.390-396
Hauptverfasser:	Ryu, C K, Jeong, H J, Lee, S K, You, H J, Choi, K U, Shim, J Y, Heo, Y H, Lee, C O
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Cell Survival - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Humans Indicators and Reagents NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors Quinolones - chemical synthesis Quinolones - pharmacology Quinones - chemical synthesis Quinones - pharmacology
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