Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential
Synthesized 6-arylamino-5,8-quinolinediones 4a-4j and 6-chloro-7-arylamino-5,8-isoquinolinediones 5a-5g were evaluated for effects on NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several...
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| Veröffentlicht in: | Archives of pharmacal research 2001-10, Vol.24 (5), p.390-396 |
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| container_title | Archives of pharmacal research |
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| creator | Ryu, C K Jeong, H J Lee, S K You, H J Choi, K U Shim, J Y Heo, Y H Lee, C O |
| description | Synthesized 6-arylamino-5,8-quinolinediones 4a-4j and 6-chloro-7-arylamino-5,8-isoquinolinediones 5a-5g were evaluated for effects on NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. The compounds 4d, 5b, 5c, 5e and 5g were comparable modulators of NQO1 activity. |
| doi_str_mv | 10.1007/BF02975181 |
| format | Article |
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The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. 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The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. 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The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. The compounds 4d, 5b, 5c, 5e and 5g were comparable modulators of NQO1 activity.</abstract><cop>Korea (South)</cop><pmid>11693537</pmid><doi>10.1007/BF02975181</doi><tpages>7</tpages></addata></record> |
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| ispartof | Archives of pharmacal research, 2001-10, Vol.24 (5), p.390-396 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Cell Survival - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Humans Indicators and Reagents NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors Quinolones - chemical synthesis Quinolones - pharmacology Quinones - chemical synthesis Quinones - pharmacology |
| title | Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential |
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