Structural Diversity of N-Sulfated Heparan Sulfate Domains:  Distinct Modes of Glucuronyl C5 Epimerization, Iduronic Acid 2-O-Sulfation, and Glucosamine 6-O-Sulfation

The N-sulfated regions (NS domains) represent the modified sequences of heparan sulfate chains and mediate interactions of the polysaccharide with proteins. We have investigated the relationship between the type/extent of polymer modification and the length of NS domains in heparan sulfate species f...

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